FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912117706> ?p ?o ?g. }

• W2912117706 endingPage "1671.e8" @default.
• W2912117706 startingPage "1658" @default.
• W2912117706 abstract "Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the United Kingdom. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-κB signaling pathways and has been documented as highly expressed in several types of human cancer. We have previously identified an autoregulatory feedback loop between iASPP and p63, which is critical in epidermal homeostasis. We hypothesized a potential role for dysregulation of this axis in the pathogenesis of keratinocyte malignancies. Immunostaining of 116 cSCC clinical samples revealed increased iASPP and ΔNp63 expression, but also highlighted a significant alteration of iASPP cellular localization, with consequent deregulation of its function. Expression patterns, functionality, and gene and microRNA expression analysis were further investigated in 10 cSCC cell lines. Our data suggest that while direct effects of iASPP and p63 upon each other’s expression are maintained in cSCC, epigenetic dysregulation of the feedback loop occurs at the microRNA level by a previously unreported mechanism controlling p63 expression. We demonstrate that this autoregulatory feedback loop controls cell migration in cSCC by blocking epithelial–mesenchymal transition and promoting proliferation, and provides future directions for clinical biomarker and therapeutic target discovery in cutaneous SCC. Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the United Kingdom. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-κB signaling pathways and has been documented as highly expressed in several types of human cancer. We have previously identified an autoregulatory feedback loop between iASPP and p63, which is critical in epidermal homeostasis. We hypothesized a potential role for dysregulation of this axis in the pathogenesis of keratinocyte malignancies. Immunostaining of 116 cSCC clinical samples revealed increased iASPP and ΔNp63 expression, but also highlighted a significant alteration of iASPP cellular localization, with consequent deregulation of its function. Expression patterns, functionality, and gene and microRNA expression analysis were further investigated in 10 cSCC cell lines. Our data suggest that while direct effects of iASPP and p63 upon each other’s expression are maintained in cSCC, epigenetic dysregulation of the feedback loop occurs at the microRNA level by a previously unreported mechanism controlling p63 expression. We demonstrate that this autoregulatory feedback loop controls cell migration in cSCC by blocking epithelial–mesenchymal transition and promoting proliferation, and provides future directions for clinical biomarker and therapeutic target discovery in cutaneous SCC." @default.
• W2912117706 created "2019-02-21" @default.
• W2912117706 creator A5001505568 @default.
• W2912117706 creator A5003180276 @default.
• W2912117706 creator A5008053312 @default.
• W2912117706 creator A5008618552 @default.
• W2912117706 creator A5031552406 @default.
• W2912117706 creator A5038930082 @default.
• W2912117706 creator A5042174545 @default.
• W2912117706 creator A5044662843 @default.
• W2912117706 creator A5052694534 @default.
• W2912117706 creator A5062246308 @default.
• W2912117706 creator A5074488959 @default.
• W2912117706 date "2019-08-01" @default.
• W2912117706 modified "2023-10-17" @default.
• W2912117706 title "Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma" @default.
• W2912117706 cites W1844747712 @default.
• W2912117706 cites W1914109619 @default.
• W2912117706 cites W1965732473 @default.
• W2912117706 cites W1970206879 @default.
• W2912117706 cites W1972334859 @default.
• W2912117706 cites W1972763019 @default.
• W2912117706 cites W1973137505 @default.
• W2912117706 cites W1973733072 @default.
• W2912117706 cites W1976324983 @default.
• W2912117706 cites W1978327754 @default.
• W2912117706 cites W1978504284 @default.
• W2912117706 cites W1979537063 @default.
• W2912117706 cites W1979627083 @default.
• W2912117706 cites W1990457668 @default.
• W2912117706 cites W1990679998 @default.
• W2912117706 cites W1993511655 @default.
• W2912117706 cites W2000854021 @default.
• W2912117706 cites W2000888446 @default.
• W2912117706 cites W2001279251 @default.
• W2912117706 cites W2006325384 @default.
• W2912117706 cites W2006466325 @default.
• W2912117706 cites W2008976455 @default.
• W2912117706 cites W2014938226 @default.
• W2912117706 cites W2019429728 @default.
• W2912117706 cites W2019538590 @default.
• W2912117706 cites W2033182545 @default.
• W2912117706 cites W2035294512 @default.
• W2912117706 cites W2035711267 @default.
• W2912117706 cites W2035815842 @default.
• W2912117706 cites W2037934612 @default.
• W2912117706 cites W2041755520 @default.
• W2912117706 cites W2051145953 @default.
• W2912117706 cites W2055493057 @default.
• W2912117706 cites W2057835520 @default.
• W2912117706 cites W2064365557 @default.
• W2912117706 cites W2073052482 @default.
• W2912117706 cites W2079863341 @default.
• W2912117706 cites W2087732778 @default.
• W2912117706 cites W2090494026 @default.
• W2912117706 cites W2102519816 @default.
• W2912117706 cites W2104197523 @default.
• W2912117706 cites W2105132188 @default.
• W2912117706 cites W2106532933 @default.
• W2912117706 cites W2107513374 @default.
• W2912117706 cites W2113645544 @default.
• W2912117706 cites W2114562058 @default.
• W2912117706 cites W2115855936 @default.
• W2912117706 cites W2118508998 @default.
• W2912117706 cites W2119501346 @default.
• W2912117706 cites W2124940507 @default.
• W2912117706 cites W2128134735 @default.
• W2912117706 cites W2130503316 @default.
• W2912117706 cites W2132569885 @default.
• W2912117706 cites W2140937677 @default.
• W2912117706 cites W2151807575 @default.
• W2912117706 cites W2152733195 @default.
• W2912117706 cites W2157466346 @default.
• W2912117706 cites W2167810415 @default.
• W2912117706 cites W2168418784 @default.
• W2912117706 cites W2255549639 @default.
• W2912117706 cites W2310459715 @default.
• W2912117706 cites W2346530374 @default.
• W2912117706 cites W2401473471 @default.
• W2912117706 cites W2507290758 @default.
• W2912117706 cites W2510883756 @default.
• W2912117706 cites W2512601254 @default.
• W2912117706 cites W2529300447 @default.
• W2912117706 cites W2533332734 @default.
• W2912117706 cites W2606523232 @default.
• W2912117706 cites W2620607073 @default.
• W2912117706 cites W2765889506 @default.
• W2912117706 cites W2773797060 @default.
• W2912117706 cites W2892065844 @default.
• W2912117706 cites W57906632 @default.
• W2912117706 cites W906179597 @default.
• W2912117706 doi "https://doi.org/10.1016/j.jid.2019.01.020" @default.
• W2912117706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30710576" @default.
• W2912117706 hasPublicationYear "2019" @default.
• W2912117706 type Work @default.
• W2912117706 sameAs 2912117706 @default.
• W2912117706 citedByCount "14" @default.
• W2912117706 countsByYear W29121177062019 @default.

• next