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• W2912118011 endingPage "336" @default.
• W2912118011 startingPage "319" @default.
• W2912118011 abstract "Drug-drug interaction (DDI) is the phenomenon of alteration of the pharmacological activity of a drug(s) when another drug(s) is co-administered in cases of so-called polypharmacy. There are three types of DDIs: pharmacokinetic (PK), pharmacodynamic, and pharmaceutical. PK is the most frequent type of DDI, which often appears as a result of the inhibition or induction of drug-metabolising enzymes (DME). In this review, we summarise in silico methods that may be applied for the prediction of the inhibition or induction of DMEs and describe appropriate computational methods for DDI prediction, showing the current situation and perspectives of these approaches in medicinal and pharmaceutical chemistry. We review sources of information on DDI, which can be used in pharmaceutical investigations and medicinal practice and/or for the creation of computational models. The problem of the inaccuracy and redundancy of these data are discussed. We provide information on the state-of-the-art physiologically- based pharmacokinetic modelling (PBPK) approaches and DME-based in silico methods. In the section on ligand-based methods, we describe pharmacophore models, molecular field analysis, quantitative structure-activity relationships (QSAR), and similarity analysis applied to the prediction of DDI related to the inhibition or induction of DME. In conclusion, we discuss the problems of DDI severity assessment, mention factors that influence severity, and highlight the issues, perspectives and practical using of in silico methods." @default.
• W2912118011 created "2019-02-21" @default.
• W2912118011 creator A5005302271 @default.
• W2912118011 creator A5014742994 @default.
• W2912118011 creator A5021812000 @default.
• W2912118011 creator A5029121475 @default.
• W2912118011 creator A5036658657 @default.
• W2912118011 creator A5050528382 @default.
• W2912118011 creator A5065866115 @default.
• W2912118011 date "2019-04-18" @default.
• W2912118011 modified "2023-09-27" @default.
• W2912118011 title "Prediction of Drug-Drug Interactions Related to Inhibition or Induction of Drug-Metabolizing Enzymes" @default.
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