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• W2912120768 abstract "A series of novel 2-benzoylbenzofuran derivatives possessing piperazine linker have been prepared, and their in vitro anticancer activity against a panel of human tumor cell lines by MTT assay were evaluated. The results demonstrated that tertiary amine derivatives exhibited better cytotoxic activity, and SAR study revealed that electron-donating substituents on the phenyl ring of the derivatization functionality contributed to potent anticancer activities. Among them, compounds 6, 9, 11, 18, 23 and 25 displayed both better anti-tumor activity and lower cytotoxic effect on human normal liver cell L02. Further apoptosis analysis showed that compound 18 significantly induced apoptosis in A549 cell, which was considered as the most potent anticancer agent." @default.
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• W2912120768 date "2019-03-01" @default.
• W2912120768 modified "2023-10-17" @default.
• W2912120768 title "2-Benzoylbenzofuran derivatives possessing piperazine linker as anticancer agents" @default.
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• W2912120768 doi "https://doi.org/10.1016/j.bmcl.2019.01.025" @default.
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