FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912121401> ?p ?o ?g. }

• W2912121401 abstract "Abstract Gentamicin is a widely used antibiotic for the treatment of gram-negative bacterial infections; however, its use often results in significant and permanent hearing loss. Hearing loss resulting from hair cell (HC) degeneration affects millions of people worldwide, and one major cause is the loss of sensory HCs in the inner ear due to aminoglycoside exposure. Strategies to overcome the apparently irreversible loss of HCs in mammals are crucial for hearing protection. Here, we report that the somatostatin analog pasireotide protects mouse cochlear HCs from gentamicin damage using a well-established in vitro gentamicin-induced HC loss model and that the otoprotective effects of pasireotide are due to Akt up-regulation via the PI3K–Akt signal pathway activation. We demonstrate active caspase signal in organ of Corti (OC) explants exposed to gentamicin and show that pasireotide treatment activates survival genes, reduces caspase signal, and increases HC survival. The neuropeptide somatostatin and its selective analogs have provided neuroprotection by activating five somatostatin receptor (SSTR1–SSTR5) subtypes. Pasireotide has a high affinity for SSTR2 and SSTR5, and the addition of SSTR2- and SSTR5-specific antagonists leads to a loss of protection. The otoprotective effects of pasireotide were also observed in a gentamicin-injured animal model. In vivo studies have shown that 13 days of subcutaneous pasireotide application prevents gentamicin-induced HC death and permanent hearing loss in mice. Auditory brainstem response analysis confirmed the protective effect of pasireotide, and we found a significant threshold shift at all measured frequencies (4, 8, 16, 24, and 32 kHz). Together, these findings indicate that pasireotide is a novel otoprotective peptide acting via the PI3K–Akt pathway and may be of therapeutic value for HC protection from ototoxic insults." @default.
• W2912121401 created "2019-02-21" @default.
• W2912121401 creator A5005271945 @default.
• W2912121401 creator A5017677495 @default.
• W2912121401 creator A5042917108 @default.
• W2912121401 creator A5058909480 @default.
• W2912121401 creator A5072584975 @default.
• W2912121401 date "2019-02-06" @default.
• W2912121401 modified "2023-10-16" @default.
• W2912121401 title "Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K–Akt pathway" @default.
• W2912121401 cites W1496964709 @default.
• W2912121401 cites W1538619419 @default.
• W2912121401 cites W182695048 @default.
• W2912121401 cites W1963632439 @default.
• W2912121401 cites W1973941114 @default.
• W2912121401 cites W1982486689 @default.
• W2912121401 cites W1984255732 @default.
• W2912121401 cites W1984621921 @default.
• W2912121401 cites W1992869932 @default.
• W2912121401 cites W1993650554 @default.
• W2912121401 cites W1996442906 @default.
• W2912121401 cites W2002742465 @default.
• W2912121401 cites W2003092473 @default.
• W2912121401 cites W2004387076 @default.
• W2912121401 cites W2004766025 @default.
• W2912121401 cites W2005314368 @default.
• W2912121401 cites W2005775837 @default.
• W2912121401 cites W2008759576 @default.
• W2912121401 cites W2012451298 @default.
• W2912121401 cites W2015270726 @default.
• W2912121401 cites W2018074007 @default.
• W2912121401 cites W2021518087 @default.
• W2912121401 cites W2030572108 @default.
• W2912121401 cites W2035258932 @default.
• W2912121401 cites W2050455948 @default.
• W2912121401 cites W2053242077 @default.
• W2912121401 cites W2053999826 @default.
• W2912121401 cites W2057353956 @default.
• W2912121401 cites W2066003738 @default.
• W2912121401 cites W2067084033 @default.
• W2912121401 cites W2072315530 @default.
• W2912121401 cites W2074607936 @default.
• W2912121401 cites W2077741291 @default.
• W2912121401 cites W2080232093 @default.
• W2912121401 cites W2083309357 @default.
• W2912121401 cites W2086487301 @default.
• W2912121401 cites W2090114628 @default.
• W2912121401 cites W2099000660 @default.
• W2912121401 cites W2122677634 @default.
• W2912121401 cites W2123963146 @default.
• W2912121401 cites W2129434381 @default.
• W2912121401 cites W2151333998 @default.
• W2912121401 cites W2154177544 @default.
• W2912121401 cites W2158639431 @default.
• W2912121401 cites W2163789638 @default.
• W2912121401 cites W2170032934 @default.
• W2912121401 cites W2559430833 @default.
• W2912121401 cites W2770062105 @default.
• W2912121401 cites W4210992659 @default.
• W2912121401 cites W4243559800 @default.
• W2912121401 doi "https://doi.org/10.1038/s41419-019-1386-7" @default.
• W2912121401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6365508" @default.
• W2912121401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30728348" @default.
• W2912121401 hasPublicationYear "2019" @default.
• W2912121401 type Work @default.
• W2912121401 sameAs 2912121401 @default.
• W2912121401 citedByCount "19" @default.
• W2912121401 countsByYear W29121214012019 @default.
• W2912121401 countsByYear W29121214012020 @default.
• W2912121401 countsByYear W29121214012021 @default.
• W2912121401 countsByYear W29121214012022 @default.
• W2912121401 countsByYear W29121214012023 @default.
• W2912121401 crossrefType "journal-article" @default.
• W2912121401 hasAuthorship W2912121401A5005271945 @default.
• W2912121401 hasAuthorship W2912121401A5017677495 @default.
• W2912121401 hasAuthorship W2912121401A5042917108 @default.
• W2912121401 hasAuthorship W2912121401A5058909480 @default.
• W2912121401 hasAuthorship W2912121401A5072584975 @default.
• W2912121401 hasBestOaLocation W29121214011 @default.
• W2912121401 hasConcept C126322002 @default.
• W2912121401 hasConcept C134018914 @default.
• W2912121401 hasConcept C150008808 @default.
• W2912121401 hasConcept C2776297358 @default.
• W2912121401 hasConcept C2776694085 @default.
• W2912121401 hasConcept C2777433750 @default.
• W2912121401 hasConcept C2778239845 @default.
• W2912121401 hasConcept C2778534666 @default.
• W2912121401 hasConcept C2778585322 @default.
• W2912121401 hasConcept C2779371878 @default.
• W2912121401 hasConcept C2780130748 @default.
• W2912121401 hasConcept C2780493683 @default.
• W2912121401 hasConcept C2984496839 @default.
• W2912121401 hasConcept C548259974 @default.
• W2912121401 hasConcept C62478195 @default.
• W2912121401 hasConcept C71315377 @default.
• W2912121401 hasConcept C71924100 @default.
• W2912121401 hasConcept C75217442 @default.
• W2912121401 hasConcept C80115893 @default.
• W2912121401 hasConcept C86554907 @default.
• W2912121401 hasConcept C86803240 @default.

• next