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• W2912123646 abstract "Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post-transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. In this review, the aberrant splicing of genes and the functional contributions of the spliced genes, in the carcinogenesis, progression and aggressiveness of cholangiocarcinoma are summarized. In addition, factors that influence this aberrant splicing that may be relevant as therapeutic targets or prognosis markers for cholangiocarcinoma are discussed." @default.
• W2912123646 created "2019-02-21" @default.
• W2912123646 creator A5003446927 @default.
• W2912123646 creator A5022887031 @default.
• W2912123646 creator A5033911138 @default.
• W2912123646 creator A5069646858 @default.
• W2912123646 date "2019-01-25" @default.
• W2912123646 modified "2023-09-25" @default.
• W2912123646 title "Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)" @default.
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