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- W2912123855 abstract "Background: Functional decline in stem cell-mediated regeneration contributes to aging associated with cellular senescence in c-kit+ cardiac progenitor cells (CPCs). Clinical implementation of CPC-based therapy with elderly patients would benefit tremendously from understanding molecular characteristics of senescence to antagonize aging. Nucleostemin (NS) is a nucleolar protein regulating stem cell proliferation and pluripotency. This study demonstrates that NS preserves characteristics associated with “stemness” and antagonizes senescence in CPCs. Methods & Results: Human adult failing heart CPCs (AhCPCs) exhibit decreased NS expression (-56%) relative to fetal human heart CPCs (FhCPC) correlating with lowered proliferation potential and shortened telomere length (p<0.01) AhCPC characteristics resemble CPCs isolated from old mice (OCPCs) with flat, senescent, multinucleated cell phenotype. OCPC phenotype is induced by NS silencing resulting in cell flattening, senescence, multinucleated cells, decreased ..." @default.
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- W2912123855 date "2014-11-25" @default.
- W2912123855 modified "2023-09-28" @default.
- W2912123855 title "Abstract 17845: Nucleostemin Maintains Cardiac Progenitor Cell “Stemness” and Cardiac Youth" @default.
- W2912123855 hasPublicationYear "2014" @default.
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