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• W2912125505 abstract "Abstract Purpose The objective of this study was to investigate the association between the administration of dipeptidyl peptidase‐4 (DPP‐4) inhibitors (cumulative duration, timing, and individual substance) and the risk of arthralgia by using a nationwide database with two methodological approaches including cohort and nested case–control study designs. Methods Using Taiwan's National Health Insurance Research Database, we identified patients who were newly prescribed with DPP‐4 inhibitors, thiazolidinediones (TZDs), or acarbose between 1 March 2009 and 31 December 2012. The exposure of studied drugs was categorized into five exclusive categories: DPP‐4 inhibitor, TZD, acarbose, combined use, or non‐use, and assessed in a time‐varying manner. Time‐dependent Cox proportional hazard models were used to estimate the association between DPP‐4 inhibitors and the risk of arthralgia. Particularly, we tested the impact of different cumulative duration, timing, and individual substance of DPP‐4 inhibitors use on risk of arthralgia. A corresponding nested case–control study using conditional logistic regression was conducted to verify this association. Results An increased risk of arthralgia was observed during the first year after initiating DPP‐4 inhibitors (adjusted Hazard Ratio = 1.35; 95% confidence interval [CI], 1.04‐1.75) but the risk declined with cumulative use. This duration–response relation was not found in TZDs use and acarbose use. In the nested case–control study, there was a slightly increased risk of arthralgia (aOR = 1.08; 95% CI, 1.04‐1.12) associated with current DPP‐4 inhibitor use. Conclusion A relatively higher risk of arthralgia was associated with the initial administration of DPP‐4 inhibitors, however, the risk declined among long‐term users." @default.
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• W2912125505 date "2019-02-06" @default.
• W2912125505 modified "2023-10-02" @default.
• W2912125505 title "Use of dipeptidyl peptidase‐4 inhibitors and the risk of arthralgia: Population‐based cohort and nested case–control studies" @default.
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• W2912125505 doi "https://doi.org/10.1002/pds.4733" @default.
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