FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912125660> ?p ?o ?g. }

• W2912125660 endingPage "422" @default.
• W2912125660 startingPage "415" @default.
• W2912125660 abstract "C1q, the recognition component of the classical complement pathway, also regulates numerous cellular processes independent of its role in complement activation. Among these processes is myeloid cell activation leading to enhanced engulfment of apoptotic cells and the regulation of proinflammatory cytokine production which is thought to be important in the prevention of autoimmunity. C1q deficiency results in a lupus-like autoimmune disease in humans, and there has been a significant effort to identify C1q receptors that might be effective targets for the manipulation of C1q-dependent cellular functions such as phagocytosis and cytokine regulation. C1q is a 460-kD hexamer containing a globular head region and collagen-like tail. Receptors for both the collagen like tail and globular head regions have been proposed and are described below. The described receptors are heterogeneous; two lack cytoplasmic tails and are found both intracellularly and extracellularly (gC1qR and calreticulin), two are Ig superfamily members (LAIR-1 and RAGE), one is a heterodimeric integrin (α2β1), two are scavenger receptors (SCARF1 and Megf10), one is a receptor for multiple complement components (CR1). In addition, two of the receptors have been previously described as receptors for collagen (α2β1 and LAIR-1), consistent with their ability to bind to the collagen-like tail of C1q. C1q is a soluble pattern-recognition receptor with a highly basic charge, it binds to multiple molecules and may regulate cell activation through multiple different receptors and/or receptor complexes. The putative C1q receptors are listed below in order of their identification." @default.
• W2912125660 created "2019-02-21" @default.
• W2912125660 creator A5011158259 @default.
• W2912125660 date "2018-01-01" @default.
• W2912125660 modified "2023-09-25" @default.
• W2912125660 title "C1q Receptors" @default.
• W2912125660 cites W1503258737 @default.
• W2912125660 cites W1511615796 @default.
• W2912125660 cites W1525273102 @default.
• W2912125660 cites W1528839689 @default.
• W2912125660 cites W1532045650 @default.
• W2912125660 cites W1555380614 @default.
• W2912125660 cites W1619222389 @default.
• W2912125660 cites W1837942605 @default.
• W2912125660 cites W1952540413 @default.
• W2912125660 cites W1962685102 @default.
• W2912125660 cites W1969921713 @default.
• W2912125660 cites W1971816068 @default.
• W2912125660 cites W1977627900 @default.
• W2912125660 cites W1982629607 @default.
• W2912125660 cites W1982954591 @default.
• W2912125660 cites W1998247442 @default.
• W2912125660 cites W2021968896 @default.
• W2912125660 cites W2034427444 @default.
• W2912125660 cites W2057763292 @default.
• W2912125660 cites W2064730444 @default.
• W2912125660 cites W2072623580 @default.
• W2912125660 cites W2076227586 @default.
• W2912125660 cites W2077764294 @default.
• W2912125660 cites W2089667868 @default.
• W2912125660 cites W2105040657 @default.
• W2912125660 cites W2105327109 @default.
• W2912125660 cites W2113733060 @default.
• W2912125660 cites W2126956583 @default.
• W2912125660 cites W2127256767 @default.
• W2912125660 cites W2155315999 @default.
• W2912125660 cites W2162509998 @default.
• W2912125660 cites W2390090246 @default.
• W2912125660 cites W4211174533 @default.
• W2912125660 cites W959290310 @default.
• W2912125660 doi "https://doi.org/10.1016/b978-0-12-810420-0.00039-0" @default.
• W2912125660 hasPublicationYear "2018" @default.
• W2912125660 type Work @default.
• W2912125660 sameAs 2912125660 @default.
• W2912125660 citedByCount "1" @default.
• W2912125660 countsByYear W29121256602019 @default.
• W2912125660 crossrefType "book-chapter" @default.
• W2912125660 hasAuthorship W2912125660A5011158259 @default.
• W2912125660 hasConcept C103474210 @default.
• W2912125660 hasConcept C111289621 @default.
• W2912125660 hasConcept C111684460 @default.
• W2912125660 hasConcept C136015124 @default.
• W2912125660 hasConcept C136449434 @default.
• W2912125660 hasConcept C170493617 @default.
• W2912125660 hasConcept C171279029 @default.
• W2912125660 hasConcept C175773311 @default.
• W2912125660 hasConcept C195687474 @default.
• W2912125660 hasConcept C203014093 @default.
• W2912125660 hasConcept C2780573682 @default.
• W2912125660 hasConcept C55493867 @default.
• W2912125660 hasConcept C86803240 @default.
• W2912125660 hasConcept C8891405 @default.
• W2912125660 hasConcept C95444343 @default.
• W2912125660 hasConceptScore W2912125660C103474210 @default.
• W2912125660 hasConceptScore W2912125660C111289621 @default.
• W2912125660 hasConceptScore W2912125660C111684460 @default.
• W2912125660 hasConceptScore W2912125660C136015124 @default.
• W2912125660 hasConceptScore W2912125660C136449434 @default.
• W2912125660 hasConceptScore W2912125660C170493617 @default.
• W2912125660 hasConceptScore W2912125660C171279029 @default.
• W2912125660 hasConceptScore W2912125660C175773311 @default.
• W2912125660 hasConceptScore W2912125660C195687474 @default.
• W2912125660 hasConceptScore W2912125660C203014093 @default.
• W2912125660 hasConceptScore W2912125660C2780573682 @default.
• W2912125660 hasConceptScore W2912125660C55493867 @default.
• W2912125660 hasConceptScore W2912125660C86803240 @default.
• W2912125660 hasConceptScore W2912125660C8891405 @default.
• W2912125660 hasConceptScore W2912125660C95444343 @default.
• W2912125660 hasLocation W29121256601 @default.
• W2912125660 hasOpenAccess W2912125660 @default.
• W2912125660 hasPrimaryLocation W29121256601 @default.
• W2912125660 hasRelatedWork W1564885418 @default.
• W2912125660 hasRelatedWork W1980882672 @default.
• W2912125660 hasRelatedWork W2053157027 @default.
• W2912125660 hasRelatedWork W2073708363 @default.
• W2912125660 hasRelatedWork W2090984178 @default.
• W2912125660 hasRelatedWork W2190283986 @default.
• W2912125660 hasRelatedWork W24165733 @default.
• W2912125660 hasRelatedWork W2896718743 @default.
• W2912125660 hasRelatedWork W2912125660 @default.
• W2912125660 hasRelatedWork W4229796216 @default.
• W2912125660 isParatext "false" @default.
• W2912125660 isRetracted "false" @default.
• W2912125660 magId "2912125660" @default.
• W2912125660 workType "book-chapter" @default.