Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912126212> ?p ?o ?g. }
- W2912126212 endingPage "322" @default.
- W2912126212 startingPage "315" @default.
- W2912126212 abstract "Objectives Peritoneal dissemination (PD) is an important cause of morbidity and mortality among patients with pancreatic ductal adenocarcinoma (PDAC). We sought to develop and characterized a novel PD mouse model by using a previously established PDAC cell line TCC-Pan2. Methods TCC-Pan2 cell line was characterized for growth rate, tumor markers, histology, and somatic mutations. TCC-Pan2 cells were implanted orthotopically to produce PD. TCC-Pan2 cells from these metastatic foci were expanded in vitro and then implanted orthotopically in mice. This PD model was used for comparing the antitumor effect of paclitaxel and NK105. Results Orthotopically implanted TCC-Pan2 cells caused tumor formation and PD with high frequency in mice. A potent metastatic subline—Pan2M—was obtained. NK105 exerted a stronger antitumor effect than paclitaxel against Pan2M cells harboring a luciferase gene (Pan2MmLuc). Notably, the survival rate on day 80 in the Pan2MmLuc mouse model was 100% for the NK105 group and 0% for the paclitaxel group. Conclusion TCC-Pan2 cell line and Pan2MmLuc PD model can serve as useful tools for monitoring the responses to antineoplastic agents and for studying PDAC biology." @default.
- W2912126212 created "2019-02-21" @default.
- W2912126212 creator A5000366018 @default.
- W2912126212 creator A5004383822 @default.
- W2912126212 creator A5038375140 @default.
- W2912126212 creator A5046439279 @default.
- W2912126212 creator A5053041120 @default.
- W2912126212 creator A5059130328 @default.
- W2912126212 creator A5086373969 @default.
- W2912126212 date "2019-03-01" @default.
- W2912126212 modified "2023-09-26" @default.
- W2912126212 title "Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line" @default.
- W2912126212 cites W1507364241 @default.
- W2912126212 cites W1514904791 @default.
- W2912126212 cites W1518520618 @default.
- W2912126212 cites W1871308790 @default.
- W2912126212 cites W1967722541 @default.
- W2912126212 cites W1982030218 @default.
- W2912126212 cites W1986546936 @default.
- W2912126212 cites W1990869510 @default.
- W2912126212 cites W2002516695 @default.
- W2912126212 cites W2004133200 @default.
- W2912126212 cites W2010149759 @default.
- W2912126212 cites W2014668585 @default.
- W2912126212 cites W2018195451 @default.
- W2912126212 cites W2026302560 @default.
- W2912126212 cites W2027034550 @default.
- W2912126212 cites W2032760352 @default.
- W2912126212 cites W2039548476 @default.
- W2912126212 cites W2044491424 @default.
- W2912126212 cites W2046170382 @default.
- W2912126212 cites W2059154414 @default.
- W2912126212 cites W2072341496 @default.
- W2912126212 cites W2075356897 @default.
- W2912126212 cites W2078516817 @default.
- W2912126212 cites W2089464452 @default.
- W2912126212 cites W2098895604 @default.
- W2912126212 cites W2100690235 @default.
- W2912126212 cites W2112927879 @default.
- W2912126212 cites W2119083670 @default.
- W2912126212 cites W2122498485 @default.
- W2912126212 cites W2133778309 @default.
- W2912126212 cites W2138566698 @default.
- W2912126212 cites W2153118978 @default.
- W2912126212 cites W2154175915 @default.
- W2912126212 cites W2160473694 @default.
- W2912126212 cites W2251242590 @default.
- W2912126212 cites W2276190994 @default.
- W2912126212 cites W2298579443 @default.
- W2912126212 cites W2320964901 @default.
- W2912126212 cites W2398029792 @default.
- W2912126212 cites W2407285488 @default.
- W2912126212 cites W2516297778 @default.
- W2912126212 cites W2553042679 @default.
- W2912126212 cites W2570618306 @default.
- W2912126212 cites W2570909166 @default.
- W2912126212 cites W2573972894 @default.
- W2912126212 cites W2587963661 @default.
- W2912126212 cites W2608139406 @default.
- W2912126212 cites W2763028478 @default.
- W2912126212 cites W2884040245 @default.
- W2912126212 doi "https://doi.org/10.1097/mpa.0000000000001253" @default.
- W2912126212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6426353" @default.
- W2912126212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30747829" @default.
- W2912126212 hasPublicationYear "2019" @default.
- W2912126212 type Work @default.
- W2912126212 sameAs 2912126212 @default.
- W2912126212 citedByCount "4" @default.
- W2912126212 countsByYear W29121262122020 @default.
- W2912126212 countsByYear W29121262122021 @default.
- W2912126212 countsByYear W29121262122023 @default.
- W2912126212 crossrefType "journal-article" @default.
- W2912126212 hasAuthorship W2912126212A5000366018 @default.
- W2912126212 hasAuthorship W2912126212A5004383822 @default.
- W2912126212 hasAuthorship W2912126212A5038375140 @default.
- W2912126212 hasAuthorship W2912126212A5046439279 @default.
- W2912126212 hasAuthorship W2912126212A5053041120 @default.
- W2912126212 hasAuthorship W2912126212A5059130328 @default.
- W2912126212 hasAuthorship W2912126212A5086373969 @default.
- W2912126212 hasBestOaLocation W29121262121 @default.
- W2912126212 hasConcept C121608353 @default.
- W2912126212 hasConcept C126322002 @default.
- W2912126212 hasConcept C142724271 @default.
- W2912126212 hasConcept C143998085 @default.
- W2912126212 hasConcept C2776694085 @default.
- W2912126212 hasConcept C2777292972 @default.
- W2912126212 hasConcept C2778764654 @default.
- W2912126212 hasConcept C2780210213 @default.
- W2912126212 hasConcept C2781182431 @default.
- W2912126212 hasConcept C2992026798 @default.
- W2912126212 hasConcept C502942594 @default.
- W2912126212 hasConcept C54355233 @default.
- W2912126212 hasConcept C57742111 @default.
- W2912126212 hasConcept C71924100 @default.
- W2912126212 hasConcept C81885089 @default.
- W2912126212 hasConcept C86803240 @default.
- W2912126212 hasConceptScore W2912126212C121608353 @default.
- W2912126212 hasConceptScore W2912126212C126322002 @default.