Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912126500> ?p ?o ?g. }
- W2912126500 abstract "Recognition of the natural abundance and functional importance of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered and intrinsically disordered protein regions (IDPRs) is changing protein science. IDPs and IDPRs; i.e., functional proteins and protein regions without unique structures, are commonly found in all organisms, where they have crucial roles in various biological processes. Disorder-based functionality complements functions of ordered proteins and domains. However, by virtue of their existence, IDPs/IDPRs, which are characterized by the remarkable conformational flexibility and structural plasticity, break multiple rules elaborated over the years to explain structure, folding, and functionality of well-folded proteins with unique structures. Despite the general believe, which dominated in protein science for more than a century, that unique biological functions of proteins require unique 3D-structures, structure-less IDPs/IDPRs are functional, being able to perform impossible tricks and to be engaged in biological activities, which are improbable for ordered proteins. With their exceptional spatio-temporal heterogeneity and high conformational flexibility, IDPs/IDPRs represent complex systems that act at the edge of chaos and are specifically tunable by various means. In this article, some of the wanders of intrinsic disorder are discussed as illustrations of their ‘mysterious’ (meta)physics." @default.
- W2912126500 created "2019-02-21" @default.
- W2912126500 creator A5083199032 @default.
- W2912126500 date "2019-02-07" @default.
- W2912126500 modified "2023-10-14" @default.
- W2912126500 title "Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics" @default.
- W2912126500 cites W121768123 @default.
- W2912126500 cites W1481607975 @default.
- W2912126500 cites W1499198785 @default.
- W2912126500 cites W1552660489 @default.
- W2912126500 cites W1568341953 @default.
- W2912126500 cites W1635552303 @default.
- W2912126500 cites W1697489839 @default.
- W2912126500 cites W1720678970 @default.
- W2912126500 cites W1774947891 @default.
- W2912126500 cites W1778452980 @default.
- W2912126500 cites W1895367194 @default.
- W2912126500 cites W1912455695 @default.
- W2912126500 cites W1952608303 @default.
- W2912126500 cites W1954438220 @default.
- W2912126500 cites W1958819694 @default.
- W2912126500 cites W1963772181 @default.
- W2912126500 cites W1964213103 @default.
- W2912126500 cites W1967203779 @default.
- W2912126500 cites W1967974247 @default.
- W2912126500 cites W1971642218 @default.
- W2912126500 cites W1972013995 @default.
- W2912126500 cites W1972376083 @default.
- W2912126500 cites W1974272997 @default.
- W2912126500 cites W1974499111 @default.
- W2912126500 cites W1975105397 @default.
- W2912126500 cites W1975121208 @default.
- W2912126500 cites W1975304761 @default.
- W2912126500 cites W1976156833 @default.
- W2912126500 cites W1978942137 @default.
- W2912126500 cites W1983534198 @default.
- W2912126500 cites W1983639468 @default.
- W2912126500 cites W1985681646 @default.
- W2912126500 cites W1988152731 @default.
- W2912126500 cites W1989511016 @default.
- W2912126500 cites W1991498388 @default.
- W2912126500 cites W1992787746 @default.
- W2912126500 cites W1994101309 @default.
- W2912126500 cites W1994369967 @default.
- W2912126500 cites W2005838473 @default.
- W2912126500 cites W2006192061 @default.
- W2912126500 cites W2008228685 @default.
- W2912126500 cites W2009019634 @default.
- W2912126500 cites W2009574796 @default.
- W2912126500 cites W2009815491 @default.
- W2912126500 cites W2010004274 @default.
- W2912126500 cites W2013270869 @default.
- W2912126500 cites W2016170088 @default.
- W2912126500 cites W2016666494 @default.
- W2912126500 cites W2018507678 @default.
- W2912126500 cites W2018633688 @default.
- W2912126500 cites W2019429351 @default.
- W2912126500 cites W2019511236 @default.
- W2912126500 cites W2020216571 @default.
- W2912126500 cites W2021172121 @default.
- W2912126500 cites W2021350329 @default.
- W2912126500 cites W2021731848 @default.
- W2912126500 cites W2022054743 @default.
- W2912126500 cites W2023298266 @default.
- W2912126500 cites W2023487073 @default.
- W2912126500 cites W2026226960 @default.
- W2912126500 cites W2027035874 @default.
- W2912126500 cites W2029807656 @default.
- W2912126500 cites W2030776726 @default.
- W2912126500 cites W2031787395 @default.
- W2912126500 cites W2031811477 @default.
- W2912126500 cites W2034299708 @default.
- W2912126500 cites W2035488660 @default.
- W2912126500 cites W2035521907 @default.
- W2912126500 cites W2036156464 @default.
- W2912126500 cites W2039251430 @default.
- W2912126500 cites W2040524431 @default.
- W2912126500 cites W2041005666 @default.
- W2912126500 cites W2041721668 @default.
- W2912126500 cites W2043308634 @default.
- W2912126500 cites W2044730187 @default.
- W2912126500 cites W2045861560 @default.
- W2912126500 cites W2046739185 @default.
- W2912126500 cites W2047009229 @default.
- W2912126500 cites W2049476357 @default.
- W2912126500 cites W2049599758 @default.
- W2912126500 cites W2049942357 @default.
- W2912126500 cites W2051301115 @default.
- W2912126500 cites W2052606462 @default.
- W2912126500 cites W2052894646 @default.
- W2912126500 cites W2054352933 @default.
- W2912126500 cites W2054843719 @default.
- W2912126500 cites W2055630932 @default.
- W2912126500 cites W2055638142 @default.
- W2912126500 cites W2056499061 @default.
- W2912126500 cites W2057251045 @default.
- W2912126500 cites W2060592742 @default.
- W2912126500 cites W2060723204 @default.
- W2912126500 cites W2061134340 @default.
- W2912126500 cites W2065534861 @default.