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- W2912131474 abstract "The anabolic effects of a supplemented diet with branched-chain amino acids, especially leucine, on skeletal muscle wasting and as a co-adjuvant in cancer treatment have been well-studied. Leucine is a precursor of protein synthesis and acts as a nutritional signal, affecting multiple metabolic processes (e.g., satiety, thermogenesis, energy efficiency, and body composition). Previous studies related to nutritional therapy have mainly focused on myopenia, which is the loss of skeletal muscle mass in some pathologies, including cancer. Leucine plays a role in the maintenance and even increase of lean body mass in healthy individuals as well as the prevention of disease states that culminate in myopenia. Herein, we review the available data addressing the mechanisms by which leucine acts as a cellular signal, thereby stimulating muscle protein synthesis, leading to the inhibition of muscle catabolism, especially in an experimental model of cancer cachexia. We also show differences found in the metabolomic and proteomic analyses, including the use of leucine in maternal diets as a preventative for muscle wasting as supported by our experimental data." @default.
- W2912131474 created "2019-02-21" @default.
- W2912131474 creator A5007923469 @default.
- W2912131474 creator A5024778148 @default.
- W2912131474 creator A5039708665 @default.
- W2912131474 creator A5046173709 @default.
- W2912131474 creator A5054788362 @default.
- W2912131474 creator A5062761730 @default.
- W2912131474 creator A5069824542 @default.
- W2912131474 creator A5091526790 @default.
- W2912131474 date "2020-01-22" @default.
- W2912131474 modified "2023-10-16" @default.
- W2912131474 title "Leucine and Its Importance for Cell Signalling Pathways in Cancer Cachexia-Induced Muscle Wasting" @default.
- W2912131474 cites W110353796 @default.
- W2912131474 cites W1510040584 @default.
- W2912131474 cites W1564746483 @default.
- W2912131474 cites W1597512020 @default.
- W2912131474 cites W1725430372 @default.
- W2912131474 cites W1815440981 @default.
- W2912131474 cites W1823586356 @default.
- W2912131474 cites W182510324 @default.
- W2912131474 cites W1966277443 @default.
- W2912131474 cites W1971884114 @default.
- W2912131474 cites W1977085472 @default.
- W2912131474 cites W1977534471 @default.
- W2912131474 cites W1979243593 @default.
- W2912131474 cites W1985800490 @default.
- W2912131474 cites W1986043256 @default.
- W2912131474 cites W1990368170 @default.
- W2912131474 cites W1993497859 @default.
- W2912131474 cites W1998867833 @default.
- W2912131474 cites W2002287253 @default.
- W2912131474 cites W2004234632 @default.
- W2912131474 cites W2004765914 @default.
- W2912131474 cites W2010484468 @default.
- W2912131474 cites W2017969831 @default.
- W2912131474 cites W2020950228 @default.
- W2912131474 cites W2021309399 @default.
- W2912131474 cites W2021957090 @default.
- W2912131474 cites W2025687108 @default.
- W2912131474 cites W2029197798 @default.
- W2912131474 cites W2030448890 @default.
- W2912131474 cites W2037817572 @default.
- W2912131474 cites W2044346844 @default.
- W2912131474 cites W2044744718 @default.
- W2912131474 cites W2047535659 @default.
- W2912131474 cites W2050286601 @default.
- W2912131474 cites W2050306968 @default.
- W2912131474 cites W2050404608 @default.
- W2912131474 cites W2050404989 @default.
- W2912131474 cites W2050502250 @default.
- W2912131474 cites W2052121973 @default.
- W2912131474 cites W2053855527 @default.
- W2912131474 cites W2054594032 @default.
- W2912131474 cites W2063507523 @default.
- W2912131474 cites W2064922908 @default.
- W2912131474 cites W2067623537 @default.
- W2912131474 cites W2070715032 @default.
- W2912131474 cites W2075623847 @default.
- W2912131474 cites W2077106952 @default.
- W2912131474 cites W2081903080 @default.
- W2912131474 cites W2088170980 @default.
- W2912131474 cites W2090008386 @default.
- W2912131474 cites W2091823485 @default.
- W2912131474 cites W2092420170 @default.
- W2912131474 cites W2093801546 @default.
- W2912131474 cites W2098487554 @default.
- W2912131474 cites W2100688137 @default.
- W2912131474 cites W2101526557 @default.
- W2912131474 cites W2106221209 @default.
- W2912131474 cites W2110448516 @default.
- W2912131474 cites W2112898640 @default.
- W2912131474 cites W2115527168 @default.
- W2912131474 cites W2118708400 @default.
- W2912131474 cites W2119303027 @default.
- W2912131474 cites W2122492598 @default.
- W2912131474 cites W2123231624 @default.
- W2912131474 cites W2123924185 @default.
- W2912131474 cites W2125939035 @default.
- W2912131474 cites W2128007752 @default.
- W2912131474 cites W2131355261 @default.
- W2912131474 cites W2136047357 @default.
- W2912131474 cites W2141317316 @default.
- W2912131474 cites W2141828390 @default.
- W2912131474 cites W2144783348 @default.
- W2912131474 cites W2150112349 @default.
- W2912131474 cites W2151283204 @default.
- W2912131474 cites W2164948224 @default.
- W2912131474 cites W2167013734 @default.
- W2912131474 cites W2167033587 @default.
- W2912131474 cites W2167039546 @default.
- W2912131474 cites W2167185127 @default.
- W2912131474 cites W2169380117 @default.
- W2912131474 cites W2169436026 @default.
- W2912131474 cites W2169903226 @default.
- W2912131474 cites W2190507182 @default.
- W2912131474 cites W2228596173 @default.
- W2912131474 cites W2262026292 @default.
- W2912131474 cites W2264616483 @default.
- W2912131474 cites W2275144007 @default.