FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912134289> ?p ?o ?g. }

• W2912134289 endingPage "S692" @default.
• W2912134289 startingPage "S691" @default.
• W2912134289 abstract "SMJN refers to cutaneous metastasis to the umbilicus. It has been reported in 1-3% of the cases with abdominopelvic malignancies. Though rare, this lesion portends a poor prognosis. It is an easily overlooked dermatological sign and can be difficult to distinguish from other common conditions such as cysts, fibromas, omphalitis or abscesses. We report a case of metastatic pancreatic adenocarcinoma that initially presented with an umbilical nodule associated with purulent discharge unresponsive to antibiotic therapy. A 71 year old female initially presented to her doctor's office with 2 week history of peri-umbilical redness and swelling with intermittent malodorous discharge, Treatment with Bactrim was unhelpful. One week later she presented to the ED with nausea and generalized abdominal pain. Lab work revealed an elevated lipase at 2200 u/L, suggestive of pancreatitis. CT scan of the abdomen revealed a 5cm cystic mass localized to the pancreatic body and tail and an area of increased soft tissue attenuation around the umbilicus with a central 9 mm fluid collection, suggestive of a possible abscess (fig.1). EUS revealed a hypoechoic, septated cystic lesion in the pancreatic body (Fig. 2). Diagnostic needle aspiration of fluid was positive for atypical cells seen in a background of necrosis. Cyst fluid CEA and serum CA 19-9 levels were elevated at 6950 u/L and 1113 u/L respectively. Due to high clinical suspicion for malignancy the non-healing, umbilical mass was biopsied. Core needle biopsy of the umbilical mass revealed malignant cells and immunohistochemistry was consistent with pancreatic adenocarcinoma (Fig. 3). Further workup was consistent with stage IV pancreatic adenocarcinoma and she was started on Folfirinox regimen. Due to progressive clinical deterioration she was transitioned to hospice care and passed away 3 months after initial presentation. SMJN, a rare clinical finding, may be the presenting feature or the only manifestation of an underlying malignancy. The most common associated primary sites are the stomach, ovaries, colon and rectum. Pancreatic adenocarcinoma accounts for 7%-9% of the SMJN cases with almost 90% of the lesions arising from the pancreatic body and tail. Detection of these lesions is based on a thorough physical examination and high clinical suspicion for malignancy in the appropriate clinical setting. Despite poor prognosis, earlier detection of these lesions can affect patient survival.Figure: EUS image shows a hypoechoic, septated cystic lesion 56.6 mm x 43.7 mm x 43 mm in maximal cross-sectional diameter in the pancreatic body with a thickened posterior wall.Figure: Biopsy of the umbilical mass consistent with metastatic pancreatic adenocarcinoma. The IHC staining pattern was positive for pankeratin, CK7, CA19.9, CEA, CK19, CDX2 and Ca125 and negative for CK20, TTF-1, Napsin A, and PAX8.Figure: CT of the abdomen shows a 5 cm cystic mass localized to the pancreatic body and tail. There is an area of attenuation around the umbilicus with a central 9 mm fluid collection, suggestive of an abscess." @default.
• W2912134289 created "2019-02-21" @default.
• W2912134289 creator A5020024902 @default.
• W2912134289 creator A5020466569 @default.
• W2912134289 creator A5031747193 @default.
• W2912134289 creator A5048995657 @default.
• W2912134289 date "2017-10-01" @default.
• W2912134289 modified "2023-09-26" @default.
• W2912134289 title "Sister Mary Josephʼs Nodule (SMJN): An Uncommon Initial Presentation of Metastatic Pancreatic Adenocarcinoma" @default.
• W2912134289 doi "https://doi.org/10.14309/00000434-201710001-01270" @default.
• W2912134289 hasPublicationYear "2017" @default.
• W2912134289 type Work @default.
• W2912134289 sameAs 2912134289 @default.
• W2912134289 citedByCount "1" @default.
• W2912134289 countsByYear W29121342892019 @default.
• W2912134289 crossrefType "journal-article" @default.
• W2912134289 hasAuthorship W2912134289A5020024902 @default.
• W2912134289 hasAuthorship W2912134289A5020466569 @default.
• W2912134289 hasAuthorship W2912134289A5031747193 @default.
• W2912134289 hasAuthorship W2912134289A5048995657 @default.
• W2912134289 hasConcept C121608353 @default.
• W2912134289 hasConcept C126322002 @default.
• W2912134289 hasConcept C141071460 @default.
• W2912134289 hasConcept C142724271 @default.
• W2912134289 hasConcept C148805740 @default.
• W2912134289 hasConcept C2775934546 @default.
• W2912134289 hasConcept C2779399171 @default.
• W2912134289 hasConcept C2781182431 @default.
• W2912134289 hasConcept C71924100 @default.
• W2912134289 hasConceptScore W2912134289C121608353 @default.
• W2912134289 hasConceptScore W2912134289C126322002 @default.
• W2912134289 hasConceptScore W2912134289C141071460 @default.
• W2912134289 hasConceptScore W2912134289C142724271 @default.
• W2912134289 hasConceptScore W2912134289C148805740 @default.
• W2912134289 hasConceptScore W2912134289C2775934546 @default.
• W2912134289 hasConceptScore W2912134289C2779399171 @default.
• W2912134289 hasConceptScore W2912134289C2781182431 @default.
• W2912134289 hasConceptScore W2912134289C71924100 @default.
• W2912134289 hasLocation W29121342891 @default.
• W2912134289 hasOpenAccess W2912134289 @default.
• W2912134289 hasPrimaryLocation W29121342891 @default.
• W2912134289 hasRelatedWork W1933168455 @default.
• W2912134289 hasRelatedWork W2170539808 @default.
• W2912134289 hasRelatedWork W2339235238 @default.
• W2912134289 hasRelatedWork W2384170671 @default.
• W2912134289 hasRelatedWork W2619182103 @default.
• W2912134289 hasRelatedWork W2811048741 @default.
• W2912134289 hasRelatedWork W3097181242 @default.
• W2912134289 hasRelatedWork W56819729 @default.
• W2912134289 hasRelatedWork W4214799196 @default.
• W2912134289 hasRelatedWork W4214955067 @default.
• W2912134289 hasVolume "112" @default.
• W2912134289 isParatext "false" @default.
• W2912134289 isRetracted "false" @default.
• W2912134289 magId "2912134289" @default.
• W2912134289 workType "article" @default.