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• W2912135806 abstract "Brown algae are valuable sources of health-benefiting compounds, such as polyphenols, proteins, and polysaccharides. In the present study, a binary solvent system of ethanol and water was used to obtain crude extracts from edible brown algae Ascophyllum nodosum. The extraction process was optimized using Box–Behnken design and response surface methodology to obtain crude extracts with strong antioxidant activity and high yield. Three variables including solvent-to-solid ratio (30–70 ml/g), ethanol concentration in the solvent system (40–80%), and extraction temperature (20–60 °C) were investigated to optimize the extraction process. The condition for maximum antioxidant activity of the crude extract was found at 70 ml/g solvent-to-solid ratio, 80% ethanol concentration, and 20 °C extraction temperature, while the condition for the highest crude extract yield was 40 ml/g solvent–solid-ratio, 44.83% ethanol concentration and 60 °C extraction temperature. Under the model-predicted optimal conditions, the predicted antioxidant activity and yield of the crude extract were 74.01 ml/g (1/IC50) and 55.60 mg extract/g-algae, which were in close agreement with the experimental results of 74.05 ml/g and 53.80 mg extract/g-algae, respectively, suggesting that the models could accurately predict and improve the extraction of antioxidants from A. nodosum." @default.
• W2912135806 created "2019-02-21" @default.
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• W2912135806 date "2019-03-01" @default.
• W2912135806 modified "2023-10-03" @default.
• W2912135806 title "Optimization of antioxidant extraction from edible brown algae Ascophyllum nodosum using response surface methodology" @default.
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• W2912135806 doi "https://doi.org/10.1016/j.fbp.2019.01.003" @default.
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