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• W2912135849 startingPage "580" @default.
• W2912135849 abstract "Porous silicon nanoparticles (pSiNPs) have been utilized within a wide spectrum of biological studies, as well as in chemistry, chemical biology, and biomedical fields. Recently, pSiNPs have been constantly coming under the spotlight, mostly in biomedical applications, due to their advantages, such as controlled-release drug delivery in vivo by hydrolysis-induced degradation, self-reporting property through long life-time photoluminescence, high loading efficiency of substrate into pore, and the homing to specific cells/organ/bacteria by surface functionalization. However, the systematic degradation rate analysis of surface-functionalized pSiNPs in different biological media has not been conducted yet. In this paper, we prepared four different surface-functionalized pSiNPs samples and analyzed the degradation rate in six different media (DI H2O (deionized water), PBS (phosphate-buffered saline), HS (human serum), DMEM (Dulbecco’s modified Eagle’s medium), LB (lysogeny broth), and BHI (brain heart infusion)). The obtained results will now contribute to understanding the correlation between surface functionalization in the pSiNPs and the degradation rate in different biological media. The characterized data with the author’s suggestions will provide useful insights in designing the new pSiNPs formulation for biomedical applications." @default.
• W2912135849 created "2019-02-21" @default.
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• W2912135849 date "2019-02-15" @default.
• W2912135849 modified "2023-10-14" @default.
• W2912135849 title "Systematic Degradation Rate Analysis of Surface-Functionalized Porous Silicon Nanoparticles" @default.
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• W2912135849 doi "https://doi.org/10.3390/ma12040580" @default.
• W2912135849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6416615" @default.
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