Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912136064> ?p ?o ?g. }
- W2912136064 endingPage "151" @default.
- W2912136064 startingPage "143" @default.
- W2912136064 abstract "The neurotoxicity of anesthetics on developing brain has been a focused issue for years. However, controversy exists between human and animal studies and surgery may be a potential reason for this. The discovery of glymphatic system, a pathway eliminating soluble substance from central nervous system (CNS), together with recent evidence that surgery-induced Aβ increase contributes to cognition dysfunction made us rethink about the influence of anesthetics on cognitive function. The function of glymphatic system was proved to be enhanced by sleep and sedation, so we assumed that under clinical situation Aβ1-40 whose accumulation played important role in cognitive dysfunction was increased by surgery and eliminated from CNS by glymphatic system. The function of glymphatic system is facilitated by aquaporin-4 (AQP-4), a water channel expressed in highly polarized manor in astrocytic endfeet, whose transcription is regulated by nuclear factor of activated T cells 5 (NFAT5). Our results suggest that under brief operation and sevoflurane exposure, surgery may be the main cause of Aβ increase and sevoflurane increase the elimination of Aβ by up-regulating AQP-4 which is the key component in glymphatic system." @default.
- W2912136064 created "2019-02-21" @default.
- W2912136064 creator A5003113407 @default.
- W2912136064 creator A5017467310 @default.
- W2912136064 creator A5018393782 @default.
- W2912136064 creator A5043490198 @default.
- W2912136064 creator A5052728876 @default.
- W2912136064 creator A5061946696 @default.
- W2912136064 date "2019-03-01" @default.
- W2912136064 modified "2023-10-10" @default.
- W2912136064 title "Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte" @default.
- W2912136064 cites W1566753041 @default.
- W2912136064 cites W1588685142 @default.
- W2912136064 cites W1767010801 @default.
- W2912136064 cites W1834249555 @default.
- W2912136064 cites W1973553804 @default.
- W2912136064 cites W1978405569 @default.
- W2912136064 cites W1998920870 @default.
- W2912136064 cites W2022521518 @default.
- W2912136064 cites W2033719672 @default.
- W2912136064 cites W2042683896 @default.
- W2912136064 cites W2049482242 @default.
- W2912136064 cites W2061127494 @default.
- W2912136064 cites W2065372694 @default.
- W2912136064 cites W2065815172 @default.
- W2912136064 cites W2070059007 @default.
- W2912136064 cites W2077462327 @default.
- W2912136064 cites W2096230518 @default.
- W2912136064 cites W2107277218 @default.
- W2912136064 cites W2118592842 @default.
- W2912136064 cites W2135735522 @default.
- W2912136064 cites W2158505111 @default.
- W2912136064 cites W2163225965 @default.
- W2912136064 cites W2167183660 @default.
- W2912136064 cites W2171259749 @default.
- W2912136064 cites W2232962770 @default.
- W2912136064 cites W2417970798 @default.
- W2912136064 cites W2474532576 @default.
- W2912136064 cites W2495695641 @default.
- W2912136064 cites W2508875112 @default.
- W2912136064 cites W2534818475 @default.
- W2912136064 cites W2552761535 @default.
- W2912136064 cites W2593106074 @default.
- W2912136064 cites W2736187772 @default.
- W2912136064 cites W2757946944 @default.
- W2912136064 cites W2768025036 @default.
- W2912136064 cites W2769041798 @default.
- W2912136064 cites W799200166 @default.
- W2912136064 doi "https://doi.org/10.1016/j.lfs.2019.02.024" @default.
- W2912136064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30763576" @default.
- W2912136064 hasPublicationYear "2019" @default.
- W2912136064 type Work @default.
- W2912136064 sameAs 2912136064 @default.
- W2912136064 citedByCount "12" @default.
- W2912136064 countsByYear W29121360642020 @default.
- W2912136064 countsByYear W29121360642021 @default.
- W2912136064 countsByYear W29121360642022 @default.
- W2912136064 countsByYear W29121360642023 @default.
- W2912136064 crossrefType "journal-article" @default.
- W2912136064 hasAuthorship W2912136064A5003113407 @default.
- W2912136064 hasAuthorship W2912136064A5017467310 @default.
- W2912136064 hasAuthorship W2912136064A5018393782 @default.
- W2912136064 hasAuthorship W2912136064A5043490198 @default.
- W2912136064 hasAuthorship W2912136064A5052728876 @default.
- W2912136064 hasAuthorship W2912136064A5061946696 @default.
- W2912136064 hasConcept C101054994 @default.
- W2912136064 hasConcept C126322002 @default.
- W2912136064 hasConcept C142724271 @default.
- W2912136064 hasConcept C15744967 @default.
- W2912136064 hasConcept C15755913 @default.
- W2912136064 hasConcept C169760540 @default.
- W2912136064 hasConcept C169900460 @default.
- W2912136064 hasConcept C172268261 @default.
- W2912136064 hasConcept C2779491297 @default.
- W2912136064 hasConcept C2779651940 @default.
- W2912136064 hasConcept C2780043718 @default.
- W2912136064 hasConcept C2781161787 @default.
- W2912136064 hasConcept C2781453256 @default.
- W2912136064 hasConcept C29730261 @default.
- W2912136064 hasConcept C42219234 @default.
- W2912136064 hasConcept C529278444 @default.
- W2912136064 hasConcept C71924100 @default.
- W2912136064 hasConceptScore W2912136064C101054994 @default.
- W2912136064 hasConceptScore W2912136064C126322002 @default.
- W2912136064 hasConceptScore W2912136064C142724271 @default.
- W2912136064 hasConceptScore W2912136064C15744967 @default.
- W2912136064 hasConceptScore W2912136064C15755913 @default.
- W2912136064 hasConceptScore W2912136064C169760540 @default.
- W2912136064 hasConceptScore W2912136064C169900460 @default.
- W2912136064 hasConceptScore W2912136064C172268261 @default.
- W2912136064 hasConceptScore W2912136064C2779491297 @default.
- W2912136064 hasConceptScore W2912136064C2779651940 @default.
- W2912136064 hasConceptScore W2912136064C2780043718 @default.
- W2912136064 hasConceptScore W2912136064C2781161787 @default.
- W2912136064 hasConceptScore W2912136064C2781453256 @default.
- W2912136064 hasConceptScore W2912136064C29730261 @default.
- W2912136064 hasConceptScore W2912136064C42219234 @default.
- W2912136064 hasConceptScore W2912136064C529278444 @default.