FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912136701> ?p ?o ?g. }

• W2912136701 endingPage "9290" @default.
• W2912136701 startingPage "9277" @default.
• W2912136701 abstract "A growing number of studies provide epidemiological evidence linking obstructive sleep apnea (OSA) with a number of chronic disorders. Transcriptional analyses have been conducted to analyze the gene expression data. However, the weighted gene coexpression network analysis (WGCNA) method has not been applied to determine the transcriptional consequence of continuous positive airway pressure (CPAP) therapy in patients with severe OSA. The aim of this study was to identify key pathways and genes in patients with OSA that are influenced by CPAP treatment and uncover/unveil potential molecular mechanisms using WGCNA. We analyzed the microarray data of OSA (GSE 49800) listed in the Gene Expression Omnibus database. Coexpression modules were constructed using WGCNA. In addition, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were also conducted. After the initial data processing, 5101 expressed gene profiles were identified. Next, a weighted gene coexpression network was established and 16 modules of coexpressed genes were identified. The interaction analysis demonstrated a relative independence of gene expression in these modules. The black module, tan module, midnightblue module, pink module, and greenyellow module were significantly associated with the alterations in circulating leukocyte gene expression at baseline and after exposure to CPAP. The five hub genes were considered to be candidate OSA-related genes after CPAP treatment. Functional enrichment analysis revealed that steroid biosynthesis, amino sugar and nucleotide sugar metabolism, protein processing in the endoplasmic reticulum, and the insulin signaling pathway play critical roles in the development of OSA in circulating leukocyte gene expression at baseline and after exposure to CPAP. Using this new systems biology approach, we identified several genes and pathways that appear to be critical to OSA after CPAP treatment, and these findings provide a better understanding of OSA pathogenesis." @default.
• W2912136701 created "2019-02-21" @default.
• W2912136701 creator A5001780997 @default.
• W2912136701 creator A5009832560 @default.
• W2912136701 creator A5018618942 @default.
• W2912136701 creator A5054874747 @default.
• W2912136701 creator A5074061450 @default.
• W2912136701 date "2019-02-05" @default.
• W2912136701 modified "2023-10-18" @default.
• W2912136701 title "Effects of CPAP on the transcriptional signatures in patients with obstructive sleep apnea via coexpression network analysis" @default.
• W2912136701 cites W1480885089 @default.
• W2912136701 cites W152319107 @default.
• W2912136701 cites W1605041796 @default.
• W2912136701 cites W1615367021 @default.
• W2912136701 cites W1714259827 @default.
• W2912136701 cites W1966327575 @default.
• W2912136701 cites W1971017480 @default.
• W2912136701 cites W1972741741 @default.
• W2912136701 cites W1980082381 @default.
• W2912136701 cites W1989119979 @default.
• W2912136701 cites W199424036 @default.
• W2912136701 cites W2056116819 @default.
• W2912136701 cites W2060705109 @default.
• W2912136701 cites W206386357 @default.
• W2912136701 cites W2083723003 @default.
• W2912136701 cites W2086341683 @default.
• W2912136701 cites W2095580030 @default.
• W2912136701 cites W2124052130 @default.
• W2912136701 cites W2132646664 @default.
• W2912136701 cites W2136850043 @default.
• W2912136701 cites W2139511828 @default.
• W2912136701 cites W2148345618 @default.
• W2912136701 cites W2158217645 @default.
• W2912136701 cites W2159675211 @default.
• W2912136701 cites W2170989872 @default.
• W2912136701 cites W229601144 @default.
• W2912136701 cites W2325768890 @default.
• W2912136701 cites W2526672647 @default.
• W2912136701 cites W2573893366 @default.
• W2912136701 cites W2580483257 @default.
• W2912136701 cites W2613486997 @default.
• W2912136701 cites W2617667192 @default.
• W2912136701 cites W2620268530 @default.
• W2912136701 cites W2730332372 @default.
• W2912136701 cites W2735812827 @default.
• W2912136701 cites W2754514704 @default.
• W2912136701 cites W4249273120 @default.
• W2912136701 cites W4294830572 @default.
• W2912136701 cites W4297924820 @default.
• W2912136701 doi "https://doi.org/10.1002/jcb.28203" @default.
• W2912136701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593761" @default.
• W2912136701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30719767" @default.
• W2912136701 hasPublicationYear "2019" @default.
• W2912136701 type Work @default.
• W2912136701 sameAs 2912136701 @default.
• W2912136701 citedByCount "4" @default.
• W2912136701 countsByYear W29121367012019 @default.
• W2912136701 countsByYear W29121367012020 @default.
• W2912136701 countsByYear W29121367012021 @default.
• W2912136701 countsByYear W29121367012022 @default.
• W2912136701 crossrefType "journal-article" @default.
• W2912136701 hasAuthorship W2912136701A5001780997 @default.
• W2912136701 hasAuthorship W2912136701A5009832560 @default.
• W2912136701 hasAuthorship W2912136701A5018618942 @default.
• W2912136701 hasAuthorship W2912136701A5054874747 @default.
• W2912136701 hasAuthorship W2912136701A5074061450 @default.
• W2912136701 hasBestOaLocation W29121367011 @default.
• W2912136701 hasConcept C104317684 @default.
• W2912136701 hasConcept C126322002 @default.
• W2912136701 hasConcept C150194340 @default.
• W2912136701 hasConcept C152724338 @default.
• W2912136701 hasConcept C186836561 @default.
• W2912136701 hasConcept C2776006263 @default.
• W2912136701 hasConcept C2987395477 @default.
• W2912136701 hasConcept C54355233 @default.
• W2912136701 hasConcept C60644358 @default.
• W2912136701 hasConcept C70721500 @default.
• W2912136701 hasConcept C71924100 @default.
• W2912136701 hasConcept C8415881 @default.
• W2912136701 hasConcept C86803240 @default.
• W2912136701 hasConceptScore W2912136701C104317684 @default.
• W2912136701 hasConceptScore W2912136701C126322002 @default.
• W2912136701 hasConceptScore W2912136701C150194340 @default.
• W2912136701 hasConceptScore W2912136701C152724338 @default.
• W2912136701 hasConceptScore W2912136701C186836561 @default.
• W2912136701 hasConceptScore W2912136701C2776006263 @default.
• W2912136701 hasConceptScore W2912136701C2987395477 @default.
• W2912136701 hasConceptScore W2912136701C54355233 @default.
• W2912136701 hasConceptScore W2912136701C60644358 @default.
• W2912136701 hasConceptScore W2912136701C70721500 @default.
• W2912136701 hasConceptScore W2912136701C71924100 @default.
• W2912136701 hasConceptScore W2912136701C8415881 @default.
• W2912136701 hasConceptScore W2912136701C86803240 @default.
• W2912136701 hasIssue "6" @default.
• W2912136701 hasLocation W29121367011 @default.
• W2912136701 hasLocation W29121367012 @default.
• W2912136701 hasLocation W29121367013 @default.
• W2912136701 hasOpenAccess W2912136701 @default.

• next