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- W2912138104 endingPage "1933" @default.
- W2912138104 startingPage "1923" @default.
- W2912138104 abstract "With the significant advances made in nanotechnology, research efforts focused on developing novel drug delivery platforms that can overcome the multitude of challenges encountered in ophthalmic drug delivery. Surface active agents (SAAs) have been extensively used for the formulation of many of the dosage forms targeting ocular tissues. Novel ophthalmic carriers utilizing SAAs were broadly classified into particulate, vesicular, and controlled release drug delivery systems. Depending on their physicochemical properties, SAAs can perform a variety of roles ranging from wetting agents, emulsifiers, stabilizers, charge inducers, solubilizers, antimicrobial agents, corneal permeation enhancers, and gelling agents. Nevertheless, their use is limited by their potential toxicity and possible interactions with other formulation ingredients. This review provides a comprehensive analysis of the different functional roles of SAAs in novel ophthalmic drug delivery platforms, their mechanism of action, and limitations that need to be considered during formulation to maximize their potential benefit. Understanding the mechanisms by which they perform their different roles and the possible interactions between SAAs and other formulation ingredients can help orientate the choice of formulators toward the SAA most suitable for the intended ocular application at a concentration that is both safe and effective." @default.
- W2912138104 created "2019-02-21" @default.
- W2912138104 creator A5022201312 @default.
- W2912138104 date "2019-06-01" @default.
- W2912138104 modified "2023-10-12" @default.
- W2912138104 title "The Role of Surface Active Agents in Ophthalmic Drug Delivery: A Comprehensive Review" @default.
- W2912138104 cites W13787203 @default.
- W2912138104 cites W1584940815 @default.
- W2912138104 cites W1889454519 @default.
- W2912138104 cites W1966337984 @default.
- W2912138104 cites W1966982589 @default.
- W2912138104 cites W1967521101 @default.
- W2912138104 cites W1971136615 @default.
- W2912138104 cites W1973587651 @default.
- W2912138104 cites W1975970944 @default.
- W2912138104 cites W1979425595 @default.
- W2912138104 cites W1980871346 @default.
- W2912138104 cites W1981433605 @default.
- W2912138104 cites W1991203164 @default.
- W2912138104 cites W1992644094 @default.
- W2912138104 cites W1993647000 @default.
- W2912138104 cites W1997008209 @default.
- W2912138104 cites W2000846494 @default.
- W2912138104 cites W2002128115 @default.
- W2912138104 cites W2006178925 @default.
- W2912138104 cites W2007406226 @default.
- W2912138104 cites W2012949361 @default.
- W2912138104 cites W2018342274 @default.
- W2912138104 cites W2018516156 @default.
- W2912138104 cites W2018606469 @default.
- W2912138104 cites W2022115052 @default.
- W2912138104 cites W2024516520 @default.
- W2912138104 cites W2026940257 @default.
- W2912138104 cites W2030968061 @default.
- W2912138104 cites W2037125542 @default.
- W2912138104 cites W2040935344 @default.
- W2912138104 cites W2043335474 @default.
- W2912138104 cites W2044606931 @default.
- W2912138104 cites W2045460362 @default.
- W2912138104 cites W2051811246 @default.
- W2912138104 cites W2052129346 @default.
- W2912138104 cites W2056427578 @default.
- W2912138104 cites W2058271681 @default.
- W2912138104 cites W2060293040 @default.
- W2912138104 cites W2061756161 @default.
- W2912138104 cites W2062042836 @default.
- W2912138104 cites W2065729269 @default.
- W2912138104 cites W2067314913 @default.
- W2912138104 cites W2068119665 @default.
- W2912138104 cites W2068664895 @default.
- W2912138104 cites W2074417814 @default.
- W2912138104 cites W2077744061 @default.
- W2912138104 cites W2082160708 @default.
- W2912138104 cites W2082993933 @default.
- W2912138104 cites W2085260077 @default.
- W2912138104 cites W2086514267 @default.
- W2912138104 cites W2086576842 @default.
- W2912138104 cites W2086835497 @default.
- W2912138104 cites W2089826626 @default.
- W2912138104 cites W2093255846 @default.
- W2912138104 cites W2093487867 @default.
- W2912138104 cites W2094643458 @default.
- W2912138104 cites W2099179147 @default.
- W2912138104 cites W2104838039 @default.
- W2912138104 cites W2106839778 @default.
- W2912138104 cites W2116499331 @default.
- W2912138104 cites W2117652097 @default.
- W2912138104 cites W2117817142 @default.
- W2912138104 cites W2129696318 @default.
- W2912138104 cites W2137340437 @default.
- W2912138104 cites W2145661073 @default.
- W2912138104 cites W2157290146 @default.
- W2912138104 cites W2158421883 @default.
- W2912138104 cites W2162546488 @default.
- W2912138104 cites W2165168948 @default.
- W2912138104 cites W2281232062 @default.
- W2912138104 cites W2286674298 @default.
- W2912138104 cites W2337039766 @default.
- W2912138104 cites W2522315394 @default.
- W2912138104 cites W2591616124 @default.
- W2912138104 cites W2599035050 @default.
- W2912138104 cites W2602923075 @default.
- W2912138104 cites W2603809109 @default.
- W2912138104 cites W2605563843 @default.
- W2912138104 cites W2739340102 @default.
- W2912138104 cites W2751333737 @default.
- W2912138104 cites W2768413943 @default.
- W2912138104 cites W2782905057 @default.
- W2912138104 cites W2790269097 @default.
- W2912138104 cites W2792831527 @default.
- W2912138104 cites W2801128792 @default.
- W2912138104 cites W3123472196 @default.
- W2912138104 cites W4233192300 @default.
- W2912138104 cites W4376595529 @default.
- W2912138104 cites W894247295 @default.
- W2912138104 doi "https://doi.org/10.1016/j.xphs.2019.01.016" @default.
- W2912138104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30684539" @default.
- W2912138104 hasPublicationYear "2019" @default.