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• W2912138626 endingPage "R221" @default.
• W2912138626 startingPage "R210" @default.
• W2912138626 abstract "A combined assessment of heart, arteries, veins, and body fluid content throughout pregnancy has not yet been reported. We hypothesized that a gradual aggravation of circulatory dysfunction exists from the latent to the clinical phase of gestational hypertensive disease (GHD), and that pathways are unique for preeclampsia with early onset < 34 wk (EPE) and late onset ≥ 34 wk (LPE), and gestational hypertension (GH). Women with singleton pregnancy and no known diseases were invited for a prospective, observational study and had standardized sphygmomanometric blood pressure measurement, bioimpedance body water spectrum analysis, impedance cardiography for cardiac and arterial assessment, and combined Doppler-ECG of hepatic and renal interlobar veins and uterine arteries. Outcome was categorized as uncomplicated (UP, n = 1,700), EPE ( n = 87), LPE ( n = 218), or GH ( n = 188). A linear mixed model for repeated measurements, corrected for age, parity, and body mass index, was employed in SAS 9.4 to analyze trimestral changes within and between groups. From the first to the third trimester, body water increased in all groups, and an increasing number of abnormal parameters relative to UP occurred in all GHD. First-trimester blood pressure and peripheral resistance were higher in GHD than UP, together with increased uterine flow resistance and extracellular water in EPE, and with lower heart rate and aorta flow velocity in LPE. An overall gestational rise of body water volumes coexists with a gradual worsening of cardiovascular dysfunction in GHD, of which pathophysiological pathways are unique for EPE, LPE, and GH, respectively." @default.
• W2912138626 created "2019-02-21" @default.
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• W2912138626 date "2019-03-01" @default.
• W2912138626 modified "2023-10-16" @default.
• W2912138626 title "Gestational hypertensive disorders show unique patterns of circulatory deterioration with ongoing pregnancy" @default.
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• W2912138626 doi "https://doi.org/10.1152/ajpregu.00075.2018" @default.
• W2912138626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30673301" @default.
• W2912138626 hasPublicationYear "2019" @default.
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