FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912140935> ?p ?o ?g. }

• W2912140935 endingPage "504" @default.
• W2912140935 startingPage "493" @default.
• W2912140935 abstract "Background Iron is a key mediator of AKI in animal models, but data on circulating iron parameters in human AKI are limited. Methods We examined results from the ARF Trial Network study to assess the association of plasma catalytic iron, total iron, transferrin, ferritin, free hemoglobin, and hepcidin with 60-day mortality. Participants included critically ill patients with AKI requiring RRT who were enrolled in the study. Results Of the 807 study participants, 409 (51%) died by day 60. In both unadjusted and multivariable adjusted models, higher plasma concentrations of catalytic iron were associated with a significantly greater risk of death, as were lower concentrations of hepcidin. After adjusting for other factors, patients with catalytic iron levels in the highest quintile versus the lowest quintile had a 4.06-fold increased risk of death, and patients with hepcidin levels in the lowest quintile versus the highest quintile of hepcidin had a 3.87-fold increased risk of death. These findings were consistent across multiple subgroups. Other iron markers were also associated with death, but the magnitude of the association was greatest for catalytic iron and hepcidin. Higher plasma concentrations of catalytic iron and lower concentrations of hepcidin are each independently associated with mortality in critically ill patients with AKI requiring RRT. Conclusions These findings suggest that plasma concentrations of catalytic iron and hepcidin may be useful prognostic markers in patients with AKI. Studies are needed to determine whether strategies to reduce catalytic iron or increase hepcidin might be beneficial in this patient population." @default.
• W2912140935 created "2019-02-21" @default.
• W2912140935 creator A5005447484 @default.
• W2912140935 creator A5020460043 @default.
• W2912140935 creator A5021022035 @default.
• W2912140935 creator A5026748157 @default.
• W2912140935 creator A5028919760 @default.
• W2912140935 creator A5036703144 @default.
• W2912140935 creator A5038618239 @default.
• W2912140935 creator A5043003425 @default.
• W2912140935 creator A5064518665 @default.
• W2912140935 creator A5075288877 @default.
• W2912140935 creator A5088158212 @default.
• W2912140935 creator A5091038949 @default.
• W2912140935 creator A5091114436 @default.
• W2912140935 date "2019-02-08" @default.
• W2912140935 modified "2023-10-10" @default.
• W2912140935 title "Iron, Hepcidin, and Death in Human AKI" @default.
• W2912140935 cites W1519933919 @default.
• W2912140935 cites W1734082729 @default.
• W2912140935 cites W1844080681 @default.
• W2912140935 cites W1898928487 @default.
• W2912140935 cites W1967117187 @default.
• W2912140935 cites W1976319056 @default.
• W2912140935 cites W1980042430 @default.
• W2912140935 cites W1986569939 @default.
• W2912140935 cites W1993555144 @default.
• W2912140935 cites W2000056470 @default.
• W2912140935 cites W2002188125 @default.
• W2912140935 cites W2004156444 @default.
• W2912140935 cites W2007440356 @default.
• W2912140935 cites W2010431026 @default.
• W2912140935 cites W2015854329 @default.
• W2912140935 cites W2025063713 @default.
• W2912140935 cites W2048835781 @default.
• W2912140935 cites W2055725201 @default.
• W2912140935 cites W2071637551 @default.
• W2912140935 cites W2071957948 @default.
• W2912140935 cites W2086910295 @default.
• W2912140935 cites W2090196513 @default.
• W2912140935 cites W2095107518 @default.
• W2912140935 cites W2112279177 @default.
• W2912140935 cites W2117437948 @default.
• W2912140935 cites W2117958746 @default.
• W2912140935 cites W2118502261 @default.
• W2912140935 cites W2124451906 @default.
• W2912140935 cites W2134843796 @default.
• W2912140935 cites W2135268119 @default.
• W2912140935 cites W2145515821 @default.
• W2912140935 cites W2150027863 @default.
• W2912140935 cites W2155965977 @default.
• W2912140935 cites W2168866606 @default.
• W2912140935 cites W2228732346 @default.
• W2912140935 cites W2253997241 @default.
• W2912140935 cites W2531541703 @default.
• W2912140935 cites W2607031541 @default.
• W2912140935 cites W2611092877 @default.
• W2912140935 cites W2793944650 @default.
• W2912140935 cites W2801429697 @default.
• W2912140935 cites W2883965892 @default.
• W2912140935 cites W4205577337 @default.
• W2912140935 doi "https://doi.org/10.1681/asn.2018100979" @default.
• W2912140935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6405140" @default.
• W2912140935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30737269" @default.
• W2912140935 hasPublicationYear "2019" @default.
• W2912140935 type Work @default.
• W2912140935 sameAs 2912140935 @default.
• W2912140935 citedByCount "35" @default.
• W2912140935 countsByYear W29121409352019 @default.
• W2912140935 countsByYear W29121409352020 @default.
• W2912140935 countsByYear W29121409352021 @default.
• W2912140935 countsByYear W29121409352022 @default.
• W2912140935 countsByYear W29121409352023 @default.
• W2912140935 crossrefType "journal-article" @default.
• W2912140935 hasAuthorship W2912140935A5005447484 @default.
• W2912140935 hasAuthorship W2912140935A5020460043 @default.
• W2912140935 hasAuthorship W2912140935A5021022035 @default.
• W2912140935 hasAuthorship W2912140935A5026748157 @default.
• W2912140935 hasAuthorship W2912140935A5028919760 @default.
• W2912140935 hasAuthorship W2912140935A5036703144 @default.
• W2912140935 hasAuthorship W2912140935A5038618239 @default.
• W2912140935 hasAuthorship W2912140935A5043003425 @default.
• W2912140935 hasAuthorship W2912140935A5064518665 @default.
• W2912140935 hasAuthorship W2912140935A5075288877 @default.
• W2912140935 hasAuthorship W2912140935A5088158212 @default.
• W2912140935 hasAuthorship W2912140935A5091038949 @default.
• W2912140935 hasAuthorship W2912140935A5091114436 @default.
• W2912140935 hasBestOaLocation W29121409351 @default.
• W2912140935 hasConcept C126322002 @default.
• W2912140935 hasConcept C22814914 @default.
• W2912140935 hasConcept C2776768029 @default.
• W2912140935 hasConcept C2778248108 @default.
• W2912140935 hasConcept C2778319317 @default.
• W2912140935 hasConcept C2778917026 @default.
• W2912140935 hasConcept C2908647359 @default.
• W2912140935 hasConcept C71924100 @default.
• W2912140935 hasConcept C90924648 @default.
• W2912140935 hasConcept C99454951 @default.

• next