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• W2912143281 abstract "Helicobacter pylori (H. pylori) is associated with a higher risk of peptic ulcer and gastric cancer. The sole presence of the bacterium is not a determinant of clinical outcome, but rather the interaction of strain type and host factors determines the risk of disease. Our aim was to study the association between bacterial load, strain type, and gastric symptoms in H. pylori-positive subjects.In a community survey, a diagnostic 13C-urea breath test for H. pylori was performed on 302 volunteers that were not taking antibiotics, antacids, or proton pump inhibitors one month prior to the test. The breath test produced 25 H. pylori-positive subjects, between 25 and 74 years of age, who then took a gastric symptoms survey and were tested for the presence of the cagA genotype in gastric juice, using the Entero-test®. Bacterial load was determined as a measure of urease activity, utilizing the delta over baseline (DOB) value, obtained in the 13C-urea breath test.A total of 48% of the H. pylori-positive subjects were cagA+. A positive association was found between cagA status and high gastric urease activity (p < 0.0001) and the latter was significantly associated with the presence of symptoms (p < 0.0001).Gastric urease activity was strongly associated with dyspeptic symptoms and cagA+ H. pylori. Elevated 13C-DOB values could be used as indicators of a higher risk for gastric disease.La Helicobacter pylori (H. pylori) está asociada con un mayor riesgo de úlcera péptica y cáncer gástrico. La presencia de la bacteria no es un factor determinante para el desenlace clínico, sino que la cepa y otros factores del huésped interactúan para determinar el riesgo a adquirir la enfermedad. El objetivo del presente estudio fue investigar la asociación entre la carga bacteriana, el tipo de cepa y los síntomas gástricos en personas con positividad a H. pylori.En una encuesta dirigida a la comunidad se contactaron 302 voluntarios que no estuvieran tomando antibióticos, antiácidos ni inhibidores de la bomba de protones un mes antes del diagnóstico de H. pylori utilizando la prueba de la ureasa en aliento. Se seleccionaron 25 sujetos con edades entre los 25 y los 74 años, positivos a H. pylori, para una encuesta de síntomas gástricos y determinar la presencia del genotipo cagA en el jugo gástrico obtenido con Entero-test®. La carga bacteriana se determinó como medida de la actividad de la ureasa utilizando el valor 13C-delta sobre el valor basal obtenido en la prueba de aliento.El 48% de los sujetos positivos a H. pylori fueron cagA+. Se encontró una asociación positiva entre el estado de cagA y la alta actividad de la ureasa gástrica (p < 0.0001), que además resultó significativamente asociada con la presencia de síntomas (p < 0.0001).La actividad de la ureasa gástrica está fuertemente asociada con los síntomas de dispepsia y la presencia de H. pylori cagA+. Los valores elevados de 13C-delta sobre el valor basal pudieran ser usados como indicadores de mayor riesgo de enfermedad gástrica." @default.
• W2912143281 created "2019-02-21" @default.
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• W2912143281 date "2019-01-01" @default.
• W2912143281 modified "2023-09-25" @default.
• W2912143281 title "P.1.29 Are schizophrenia and bipolar polygenic risk scores associated with positive and manic symptoms at psychosis onset?" @default.
• W2912143281 doi "https://doi.org/10.1016/j.euroneuro.2019.01.031" @default.
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