FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912144212> ?p ?o ?g. }

• W2912144212 endingPage "47" @default.
• W2912144212 startingPage "39" @default.
• W2912144212 abstract "Chemophototherapy (CPT) merges photodynamic therapy with chemotherapy and can substantially enhance drug delivery. Using a singular liposomal formulation for CPT, we describe a semi-mechanistic pharmacokinetic-pharmacodynamic (PK/PD) model to investigate observed antitumor effects. Long-circulating, sterically-stabilized liposomes loaded with doxorubicin (Dox) stably incorporate small amounts of a porphyrin-phospholipid (PoP) photosensitizer in the bilayer. These were administered intravenously to mice bearing low-passage, patient-derived pancreatic cancer xenografts (PDX). Dox PK was described with a two-compartment model and tumor drug disposition kinetics were modeled with first-order influx and efflux rates. Tumor irradiation with 665 nm laser light (200 J/cm2) 1 h after liposome administration increased tumor vascular permeabilization and drug accumulation, which was accounted for in the PK/PD model with increased tumor influx and efflux rates by approximately 12- and 4- fold, respectively. This modeling approach provided an overall 7-fold increase in Dox area under the curve in the tumor, matching experimental data (7.4-fold). A signal transduction model based on nonlinear direct cell killing accounted for observed tumor growth patterns. This PK/PD model adequately describes the CPT anti-PDX tumor response based on enhanced drug delivery at the short drug-light interval used." @default.
• W2912144212 created "2019-02-21" @default.
• W2912144212 creator A5004070980 @default.
• W2912144212 creator A5004556853 @default.
• W2912144212 creator A5021901997 @default.
• W2912144212 creator A5036973925 @default.
• W2912144212 creator A5038572107 @default.
• W2912144212 creator A5045314927 @default.
• W2912144212 creator A5057883761 @default.
• W2912144212 creator A5072843517 @default.
• W2912144212 creator A5074885622 @default.
• W2912144212 date "2019-03-01" @default.
• W2912144212 modified "2023-10-14" @default.
• W2912144212 title "Pharmacokinetics and pharmacodynamics of liposomal chemophototherapy with short drug-light intervals" @default.
• W2912144212 cites W1518207709 @default.
• W2912144212 cites W1607545743 @default.
• W2912144212 cites W1825341184 @default.
• W2912144212 cites W1913521652 @default.
• W2912144212 cites W1966757630 @default.
• W2912144212 cites W1985957186 @default.
• W2912144212 cites W1999082469 @default.
• W2912144212 cites W2001678949 @default.
• W2912144212 cites W2009038500 @default.
• W2912144212 cites W2011649365 @default.
• W2912144212 cites W2013316743 @default.
• W2912144212 cites W2029942079 @default.
• W2912144212 cites W2036944284 @default.
• W2912144212 cites W2043594693 @default.
• W2912144212 cites W2044493956 @default.
• W2912144212 cites W2044590347 @default.
• W2912144212 cites W2055091294 @default.
• W2912144212 cites W2063338965 @default.
• W2912144212 cites W2063909696 @default.
• W2912144212 cites W2093429871 @default.
• W2912144212 cites W2107441200 @default.
• W2912144212 cites W2108836062 @default.
• W2912144212 cites W2112499513 @default.
• W2912144212 cites W2118952409 @default.
• W2912144212 cites W2131070390 @default.
• W2912144212 cites W2136226205 @default.
• W2912144212 cites W2141713397 @default.
• W2912144212 cites W2149216903 @default.
• W2912144212 cites W2150758813 @default.
• W2912144212 cites W2151734986 @default.
• W2912144212 cites W2152272197 @default.
• W2912144212 cites W2159577992 @default.
• W2912144212 cites W2162759408 @default.
• W2912144212 cites W2165824272 @default.
• W2912144212 cites W2166699632 @default.
• W2912144212 cites W2175185830 @default.
• W2912144212 cites W2180195648 @default.
• W2912144212 cites W2187917981 @default.
• W2912144212 cites W2226458673 @default.
• W2912144212 cites W2301135976 @default.
• W2912144212 cites W2343061763 @default.
• W2912144212 cites W2396545253 @default.
• W2912144212 cites W2550095838 @default.
• W2912144212 cites W2580285549 @default.
• W2912144212 cites W2593880624 @default.
• W2912144212 cites W2615084686 @default.
• W2912144212 cites W2796187026 @default.
• W2912144212 cites W4247785462 @default.
• W2912144212 doi "https://doi.org/10.1016/j.jconrel.2019.01.030" @default.
• W2912144212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6399029" @default.
• W2912144212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30684512" @default.
• W2912144212 hasPublicationYear "2019" @default.
• W2912144212 type Work @default.
• W2912144212 sameAs 2912144212 @default.
• W2912144212 citedByCount "46" @default.
• W2912144212 countsByYear W29121442122019 @default.
• W2912144212 countsByYear W29121442122020 @default.
• W2912144212 countsByYear W29121442122021 @default.
• W2912144212 countsByYear W29121442122022 @default.
• W2912144212 countsByYear W29121442122023 @default.
• W2912144212 crossrefType "journal-article" @default.
• W2912144212 hasAuthorship W2912144212A5004070980 @default.
• W2912144212 hasAuthorship W2912144212A5004556853 @default.
• W2912144212 hasAuthorship W2912144212A5021901997 @default.
• W2912144212 hasAuthorship W2912144212A5036973925 @default.
• W2912144212 hasAuthorship W2912144212A5038572107 @default.
• W2912144212 hasAuthorship W2912144212A5045314927 @default.
• W2912144212 hasAuthorship W2912144212A5057883761 @default.
• W2912144212 hasAuthorship W2912144212A5072843517 @default.
• W2912144212 hasAuthorship W2912144212A5074885622 @default.
• W2912144212 hasBestOaLocation W29121442121 @default.
• W2912144212 hasConcept C111113717 @default.
• W2912144212 hasConcept C112705442 @default.
• W2912144212 hasConcept C12554922 @default.
• W2912144212 hasConcept C126322002 @default.
• W2912144212 hasConcept C178790620 @default.
• W2912144212 hasConcept C185154212 @default.
• W2912144212 hasConcept C185592680 @default.
• W2912144212 hasConcept C200082930 @default.
• W2912144212 hasConcept C2776694085 @default.
• W2912144212 hasConcept C2779820397 @default.
• W2912144212 hasConcept C2780035454 @default.
• W2912144212 hasConcept C2781303535 @default.
• W2912144212 hasConcept C2781469039 @default.

• next