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- W2912145050 abstract "Lipid membranes play a central role in many biological phenomena at the cellular level. Much work over the past decades has been devoted to symmetric membranes, but it is known that in living matter membranes are almost always asymmetric, meaning that they consist of leaflets that differ in their compositions. Recent experiments have found that the bending rigidity of compositionally asymmetric membranes can be more than twice that of symmetric membranes. This conflicts with the expectation that the rigidity of a compositionally asymmetric membrane should be the average rigidity of the two corresponding symmetric bilayers. We argue that while asymmetry between the leaflets can indeed increase a bilayer's rigidity, the observed effect should be attributed to stress asymmetry and not a lack of additivity of monolayer rigidities. Using coarse-grained molecular dynamics simulations, we show that membranes begin to stiffen when this differential stress exceeds some minimum threshold. These findings also show that it is insufficient to classify the state of an asymmetric membrane via the composition alone without also specifying its differential stress. Our results have important implications for biological membranes, for which the effects of stress asymmetry on elastic properties is yet to be investigated." @default.
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- W2912145050 date "2019-02-01" @default.
- W2912145050 modified "2023-10-18" @default.
- W2912145050 title "Rigidity of Asymmetric and Asymmetrically Stressed Membranes" @default.
- W2912145050 doi "https://doi.org/10.1016/j.bpj.2018.11.522" @default.
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