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- W2912145146 abstract "Background: Hypercholesterolemia is an atherosclerotic condition associated with endothelial dysfunction and impaired neovascularization in response to ischemia. This study sought to define the role of the anti-inflammatory microRNA-146b (miR-146b) in that pathophysiology. Methods and results: qRT-PCR analyses showed that the expression of miR-146b is significantly reduced in the ischemic muscles of hypercholesterolemic ApoE-deficient (ApoE-/-) mice, and in HUVECs exposed to oxLDL. Inhibition of miR-146b (antimiR-146b) in native HUVECs impairs angiogenesis in vitro. On the other hand, forced expression of miR-146b using a miR mimic can rescue oxLDL-mediated impairment of endothelial cell migration and tubule formation. Using a mouse model of hindlimb ischemia, we found that intramuscular injection of miR-146b mimic restores blood flow recuperation, increases vascular densities in ischemic muscles, and reduces ischemic damages in hypercholesterolemic ApoE-/- mice. In addition, miR-146b treatment also incre..." @default.
- W2912145146 created "2019-02-21" @default.
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- W2912145146 date "2017-11-14" @default.
- W2912145146 modified "2023-09-25" @default.
- W2912145146 title "Abstract 18902: Reduced Expression of Microrna-146b Contributes to Impair Ischemia-induced Neovascularization in Hypercholesterolemic Conditions" @default.
- W2912145146 hasPublicationYear "2017" @default.
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