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- W2912145156 abstract "Purpose Blood oxygen level dependent (BOLD) MRI based on measurements can provide insights into tumor vascular oxygenation. However, measurements are susceptible to blood flow, which may vary accompanying a hyperoxic gas challenge. We investigated flow sensitivity by comparing measurements with and without flow suppression (fs) in 2 orthotopic lung xenograft tumor models. Methods H460 (n = 20) and A549 (n = 20) human lung tumor xenografts were induced by surgical implantation of cancer cells in the right lung of nude rats. MRI was performed at 4.7T after tumors reached 5 to 8 mm in diameter. A multiecho gradient echo MRI sequence was acquired with and without spatial saturation bands on each side of the imaging plane to evaluate the effect of flow on . fs and non‐fs MRI measurements were interleaved during an oxygen breathing challenge (from air to 100% O 2 ). ‐weighted signal intensity changes (ΔSI(%)) and measurements were obtained for regions of interest and on a voxel‐by‐voxel basis and discrepancies quantified with Bland–Altman analysis. Results Flow suppression affected ΔSI(%) and measurements in each tumor model. Average discrepancy and limits of agreement from Bland–Altman analyses revealed greater flow‐related bias in A549 than H460. Conclusion The effect of flow on , and hence BOLD, was tumor model dependent with measurements being more sensitive in well‐perfused A549 tumors." @default.
- W2912145156 created "2019-02-21" @default.
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- W2912145156 date "2019-01-30" @default.
- W2912145156 modified "2023-10-15" @default.
- W2912145156 title "The effect of flow on blood oxygen level dependent (R<sup>*</sup><sub>2</sub>) MRI of orthotopic lung tumors" @default.
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- W2912145156 doi "https://doi.org/10.1002/mrm.27661" @default.
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