FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912147734> ?p ?o ?g. }

• W2912147734 endingPage "72" @default.
• W2912147734 startingPage "65" @default.
• W2912147734 abstract "The pituitary is a central organ of the neuro-endocrine system in fish that plays critical roles in various physiological processes, including stress response and behavior. Although it is known that pituitary hormones can have a direct or indirect influence stimulating or suppressing the immune responses, whether there is a local immune response in the pituitary or what is the effect of the immune stimulus on the pituitary function in fish is unknown. With the aim to understand the interaction between the immune responses and the endocrine axes at the pituitary level, particularly the Hypothalamus-Pituitary-Interrenal (HPI) axis, pituitaries of rainbow trout (Oncorhynchus mykiss) were cultured in vitro, incubated with bacterin, or bacterin plus CRH, cortisol, human recombinant IL1β, or spleen medium for 3 h, and then genes involved in pro-inflammation (il1β, il8, tnfα1, ifnγ), anti-inflammation (tgfβ1b, il10), immune modulation (mhcIIa, c3, mif) and stress response (crhbp, pomca, pomcb, gr1) were tested. Data showed that, incubation with bacterin alone and bacterin plus recombinant IL1β or CRH, as well as medium from bacterin treated spleen caused significant up-regulation of pro-inflammatory genes il1β and il8, while down-regulated the anti-inflammatory gene tgfβ1b. Besides, recombinant IL1β plus bacterin or alone caused raise of mhcIIa and tnfa, respectively. On the contrary, just a slight or even no alteration was recorded in the expression of stress response genes including crhbp, pomca, pomcb and gr1 in the in vitro cultured trout pituitary following this stimulation. These results suggest a local immune gene equipment in the pituitary of fish, and the potential for fish pituitary to develop both innate and adaptive immune responses, whereas that immune stimulation was not able to evoke a significant endocrine stress response in vitro." @default.
• W2912147734 created "2019-02-21" @default.
• W2912147734 creator A5005430575 @default.
• W2912147734 creator A5039708243 @default.
• W2912147734 creator A5079043263 @default.
• W2912147734 date "2019-05-01" @default.
• W2912147734 modified "2023-09-27" @default.
• W2912147734 title "Fish pituitary show an active immune response after in vitro stimulation with Vibrio bacterin" @default.
• W2912147734 cites W1964153074 @default.
• W2912147734 cites W1970725883 @default.
• W2912147734 cites W1981755124 @default.
• W2912147734 cites W1993537924 @default.
• W2912147734 cites W1997571842 @default.
• W2912147734 cites W1999182152 @default.
• W2912147734 cites W2002364545 @default.
• W2912147734 cites W2020602322 @default.
• W2912147734 cites W2022979746 @default.
• W2912147734 cites W2026367294 @default.
• W2912147734 cites W2029027714 @default.
• W2912147734 cites W2030567344 @default.
• W2912147734 cites W2034311142 @default.
• W2912147734 cites W2037539108 @default.
• W2912147734 cites W2050792651 @default.
• W2912147734 cites W2057119181 @default.
• W2912147734 cites W2063616307 @default.
• W2912147734 cites W2074714853 @default.
• W2912147734 cites W2076260880 @default.
• W2912147734 cites W2089244707 @default.
• W2912147734 cites W2091973725 @default.
• W2912147734 cites W2108244474 @default.
• W2912147734 cites W2112818206 @default.
• W2912147734 cites W2119611498 @default.
• W2912147734 cites W2124117129 @default.
• W2912147734 cites W2149819083 @default.
• W2912147734 cites W2164137914 @default.
• W2912147734 cites W2167827899 @default.
• W2912147734 cites W2169010806 @default.
• W2912147734 cites W2808585410 @default.
• W2912147734 cites W4238490072 @default.
• W2912147734 cites W904255362 @default.
• W2912147734 cites W92504502 @default.
• W2912147734 cites W97703087 @default.
• W2912147734 doi "https://doi.org/10.1016/j.ygcen.2019.02.011" @default.
• W2912147734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30769010" @default.
• W2912147734 hasPublicationYear "2019" @default.
• W2912147734 type Work @default.
• W2912147734 sameAs 2912147734 @default.
• W2912147734 citedByCount "4" @default.
• W2912147734 countsByYear W29121477342019 @default.
• W2912147734 countsByYear W29121477342020 @default.
• W2912147734 countsByYear W29121477342021 @default.
• W2912147734 countsByYear W29121477342022 @default.
• W2912147734 crossrefType "journal-article" @default.
• W2912147734 hasAuthorship W2912147734A5005430575 @default.
• W2912147734 hasAuthorship W2912147734A5039708243 @default.
• W2912147734 hasAuthorship W2912147734A5079043263 @default.
• W2912147734 hasConcept C126322002 @default.
• W2912147734 hasConcept C134018914 @default.
• W2912147734 hasConcept C17991360 @default.
• W2912147734 hasConcept C203014093 @default.
• W2912147734 hasConcept C24998067 @default.
• W2912147734 hasConcept C2776914184 @default.
• W2912147734 hasConcept C2779363728 @default.
• W2912147734 hasConcept C2780931953 @default.
• W2912147734 hasConcept C2909208804 @default.
• W2912147734 hasConcept C46699223 @default.
• W2912147734 hasConcept C505870484 @default.
• W2912147734 hasConcept C71315377 @default.
• W2912147734 hasConcept C71924100 @default.
• W2912147734 hasConcept C86803240 @default.
• W2912147734 hasConcept C8891405 @default.
• W2912147734 hasConceptScore W2912147734C126322002 @default.
• W2912147734 hasConceptScore W2912147734C134018914 @default.
• W2912147734 hasConceptScore W2912147734C17991360 @default.
• W2912147734 hasConceptScore W2912147734C203014093 @default.
• W2912147734 hasConceptScore W2912147734C24998067 @default.
• W2912147734 hasConceptScore W2912147734C2776914184 @default.
• W2912147734 hasConceptScore W2912147734C2779363728 @default.
• W2912147734 hasConceptScore W2912147734C2780931953 @default.
• W2912147734 hasConceptScore W2912147734C2909208804 @default.
• W2912147734 hasConceptScore W2912147734C46699223 @default.
• W2912147734 hasConceptScore W2912147734C505870484 @default.
• W2912147734 hasConceptScore W2912147734C71315377 @default.
• W2912147734 hasConceptScore W2912147734C71924100 @default.
• W2912147734 hasConceptScore W2912147734C86803240 @default.
• W2912147734 hasConceptScore W2912147734C8891405 @default.
• W2912147734 hasLocation W29121477341 @default.
• W2912147734 hasLocation W29121477342 @default.
• W2912147734 hasOpenAccess W2912147734 @default.
• W2912147734 hasPrimaryLocation W29121477341 @default.
• W2912147734 hasRelatedWork W1984619393 @default.
• W2912147734 hasRelatedWork W1997759048 @default.
• W2912147734 hasRelatedWork W2027210979 @default.
• W2912147734 hasRelatedWork W2034768996 @default.
• W2912147734 hasRelatedWork W2054992011 @default.
• W2912147734 hasRelatedWork W2064416809 @default.
• W2912147734 hasRelatedWork W2107664466 @default.
• W2912147734 hasRelatedWork W2163700154 @default.

• next