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• W2912148688 abstract "Long-term monitoring of intrinsic electrocardiogram (ECG) in zebrafish plays a crucial role in heart disease studies and drug screening. In this paper, we developed a polymer-based apparatus with embedded flexible thin-film electrodes to acquire ECG signals of awake zebrafish. The apparatus was made of polydimethylsiloxane using the molding technique with molds formed by 3D printing. A graphical user interface was built in National Instruments LabView platform for real-time recording, processing, and analysis. The program provided important features, such as signal de-noising, characteristic wave detection, and anomaly detection. Further, it could operate on both real-time coming signals and previously-saved data, facilitating analysis and interpretation. We demonstrated the use of our system to investigate the effects of the anesthetic drug, namely Tricaine (MS-222), on cardiac electrophysiology of zebrafish, revealing promising findings. We speculate that our novel system may contribute to a host of studies in various disciplines using the zebrafish model." @default.
• W2912148688 created "2019-02-21" @default.
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• W2912148688 date "2019-06-01" @default.
• W2912148688 modified "2023-10-05" @default.
• W2912148688 title "Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish" @default.
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• W2912148688 doi "https://doi.org/10.1109/jsen.2019.2897789" @default.
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