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- W2912149374 startingPage "362" @default.
- W2912149374 abstract "Apoptosis plays a critical role during normal development and homeostasis of adult tissues. Consequently, deregulation of apoptosis is associated with numerous diseases ranging from cancer to neurodegeneration. In this article, we describe in biochemical and structural detail the mechanisms that mediate the activation of cysteinyl aspartate-specific proteases (caspases) within large multimeric complexes following the stimulation of death receptors and/or the perturbation of various intracellular organelles. In doing so, we discuss those factors that directly or indirectly regulate the activation (or activity) of caspases, including pro- and antiapoptotic BCL-2 family members, inhibitor of apoptosis (IAP) proteins, and IAP antagonists. We also briefly discuss highly related protein complexes that mediate an alternative form of cell death in cells lacking caspase activity." @default.
- W2912149374 created "2019-02-21" @default.
- W2912149374 creator A5005765950 @default.
- W2912149374 creator A5064548181 @default.
- W2912149374 date "2018-01-01" @default.
- W2912149374 modified "2023-10-16" @default.
- W2912149374 title "Apoptosis" @default.
- W2912149374 cites W1133270011 @default.
- W2912149374 cites W1193554 @default.
- W2912149374 cites W135294775 @default.
- W2912149374 cites W1480948328 @default.
- W2912149374 cites W1484817497 @default.
- W2912149374 cites W1506642042 @default.
- W2912149374 cites W1513960270 @default.
- W2912149374 cites W1523845694 @default.
- W2912149374 cites W1538986472 @default.
- W2912149374 cites W1557686543 @default.
- W2912149374 cites W1566777539 @default.
- W2912149374 cites W1591646293 @default.
- W2912149374 cites W1595083214 @default.
- W2912149374 cites W1604195255 @default.
- W2912149374 cites W1616121322 @default.
- W2912149374 cites W1618299283 @default.
- W2912149374 cites W1644794975 @default.
- W2912149374 cites W1660893922 @default.
- W2912149374 cites W171737858 @default.
- W2912149374 cites W1768187423 @default.
- W2912149374 cites W1803162504 @default.
- W2912149374 cites W1812279404 @default.
- W2912149374 cites W1836073275 @default.
- W2912149374 cites W1849921110 @default.
- W2912149374 cites W1850224498 @default.
- W2912149374 cites W1890027265 @default.
- W2912149374 cites W1890121728 @default.
- W2912149374 cites W1905806846 @default.
- W2912149374 cites W1911240597 @default.
- W2912149374 cites W1927308462 @default.
- W2912149374 cites W1940692702 @default.
- W2912149374 cites W1948927501 @default.
- W2912149374 cites W1950343975 @default.
- W2912149374 cites W1953569147 @default.
- W2912149374 cites W1963848568 @default.
- W2912149374 cites W1964734680 @default.
- W2912149374 cites W1965217295 @default.
- W2912149374 cites W1965732243 @default.
- W2912149374 cites W1966798559 @default.
- W2912149374 cites W1967824812 @default.
- W2912149374 cites W1967894078 @default.
- W2912149374 cites W1968117332 @default.
- W2912149374 cites W1968160256 @default.
- W2912149374 cites W1968295892 @default.
- W2912149374 cites W1969070574 @default.
- W2912149374 cites W1969331809 @default.
- W2912149374 cites W1969855050 @default.
- W2912149374 cites W1970724938 @default.
- W2912149374 cites W1971160184 @default.
- W2912149374 cites W1971256455 @default.
- W2912149374 cites W1971411560 @default.
- W2912149374 cites W1971518346 @default.
- W2912149374 cites W1972546884 @default.
- W2912149374 cites W1972835366 @default.
- W2912149374 cites W1972936061 @default.
- W2912149374 cites W1973109581 @default.
- W2912149374 cites W1973680986 @default.
- W2912149374 cites W1973748645 @default.
- W2912149374 cites W1974349185 @default.
- W2912149374 cites W1975291295 @default.
- W2912149374 cites W1976141746 @default.
- W2912149374 cites W1976183089 @default.
- W2912149374 cites W1976312800 @default.
- W2912149374 cites W1976720365 @default.
- W2912149374 cites W1976883744 @default.
- W2912149374 cites W1976935037 @default.
- W2912149374 cites W1977258127 @default.
- W2912149374 cites W1977373195 @default.
- W2912149374 cites W1978235810 @default.
- W2912149374 cites W1978527995 @default.
- W2912149374 cites W1978841975 @default.
- W2912149374 cites W1979032223 @default.
- W2912149374 cites W1979489548 @default.
- W2912149374 cites W1979520552 @default.
- W2912149374 cites W1979607272 @default.
- W2912149374 cites W1979664185 @default.
- W2912149374 cites W1979791199 @default.
- W2912149374 cites W1979975373 @default.
- W2912149374 cites W1979995768 @default.
- W2912149374 cites W1980768491 @default.
- W2912149374 cites W1981006523 @default.
- W2912149374 cites W1981166298 @default.
- W2912149374 cites W1981867302 @default.
- W2912149374 cites W1982124131 @default.
- W2912149374 cites W1983151602 @default.
- W2912149374 cites W1983398917 @default.
- W2912149374 cites W1984448159 @default.
- W2912149374 cites W1984547206 @default.
- W2912149374 cites W1984636849 @default.
- W2912149374 cites W1984925149 @default.
- W2912149374 cites W1985063313 @default.