Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912150716> ?p ?o ?g. }
- W2912150716 endingPage "10067" @default.
- W2912150716 startingPage "10061" @default.
- W2912150716 abstract "The development of new therapies for surgical adhesions has proven to be difficult as there is no consistently effective way to assess treatment efficacy in clinical trials without performing a second surgery, which can result in additional adhesions. We have developed lipid microbubble formulations that use a short peptide sequence, CREKA, to target fibrin, the molecule that forms nascent adhesions. These targeted polymerized shell microbubbles (PSMs) are designed to allow ultrasound imaging of early adhesions for diagnostic purposes and for evaluating the success of potential treatments in clinical trials while acting as a possible treatment. In this study, we show that CREKA-targeted microbubbles preferentially bind fibrin over fibrinogen and are stable for long periods of time (∼48 h), that these bound microbubbles can be visualized by ultrasound, and that neither these lipid-based bubbles nor their diagnostic-ultrasound-induced vibrations damage mesothelial cells in vitro. Moreover, these bubbles show the potential to identify adhesionlike fibrin formations and may hold promise in blocking or breaking up fibrin formations in vivo." @default.
- W2912150716 created "2019-02-21" @default.
- W2912150716 creator A5018290408 @default.
- W2912150716 creator A5030419876 @default.
- W2912150716 creator A5031728337 @default.
- W2912150716 creator A5034459252 @default.
- W2912150716 creator A5048117106 @default.
- W2912150716 creator A5063266058 @default.
- W2912150716 creator A5067068754 @default.
- W2912150716 creator A5072474961 @default.
- W2912150716 creator A5077881806 @default.
- W2912150716 creator A5085272133 @default.
- W2912150716 date "2019-01-25" @default.
- W2912150716 modified "2023-10-01" @default.
- W2912150716 title "Fibrin-Targeted Polymerized Shell Microbubbles as Potential Theranostic Agents for Surgical Adhesions" @default.
- W2912150716 cites W1866759065 @default.
- W2912150716 cites W1969793936 @default.
- W2912150716 cites W1988828468 @default.
- W2912150716 cites W1990036692 @default.
- W2912150716 cites W2007292189 @default.
- W2912150716 cites W2016132243 @default.
- W2912150716 cites W2016623886 @default.
- W2912150716 cites W2024847551 @default.
- W2912150716 cites W2026908430 @default.
- W2912150716 cites W2032442431 @default.
- W2912150716 cites W2034228245 @default.
- W2912150716 cites W2043688195 @default.
- W2912150716 cites W2047023779 @default.
- W2912150716 cites W2050085273 @default.
- W2912150716 cites W2051184641 @default.
- W2912150716 cites W2055492146 @default.
- W2912150716 cites W2068932219 @default.
- W2912150716 cites W2070553707 @default.
- W2912150716 cites W2079933267 @default.
- W2912150716 cites W2080659630 @default.
- W2912150716 cites W2084150757 @default.
- W2912150716 cites W2092715757 @default.
- W2912150716 cites W2093507045 @default.
- W2912150716 cites W2109653762 @default.
- W2912150716 cites W2110582342 @default.
- W2912150716 cites W2113569199 @default.
- W2912150716 cites W2122017924 @default.
- W2912150716 cites W2131331106 @default.
- W2912150716 cites W2133252734 @default.
- W2912150716 cites W2146117604 @default.
- W2912150716 cites W2149274023 @default.
- W2912150716 cites W2342518235 @default.
- W2912150716 cites W2541292018 @default.
- W2912150716 cites W4213018315 @default.
- W2912150716 cites W4247750798 @default.
- W2912150716 cites W4366065050 @default.
- W2912150716 doi "https://doi.org/10.1021/acs.langmuir.8b03692" @default.
- W2912150716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6767917" @default.
- W2912150716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30681875" @default.
- W2912150716 hasPublicationYear "2019" @default.
- W2912150716 type Work @default.
- W2912150716 sameAs 2912150716 @default.
- W2912150716 citedByCount "11" @default.
- W2912150716 countsByYear W29121507162019 @default.
- W2912150716 countsByYear W29121507162020 @default.
- W2912150716 countsByYear W29121507162021 @default.
- W2912150716 countsByYear W29121507162022 @default.
- W2912150716 crossrefType "journal-article" @default.
- W2912150716 hasAuthorship W2912150716A5018290408 @default.
- W2912150716 hasAuthorship W2912150716A5030419876 @default.
- W2912150716 hasAuthorship W2912150716A5031728337 @default.
- W2912150716 hasAuthorship W2912150716A5034459252 @default.
- W2912150716 hasAuthorship W2912150716A5048117106 @default.
- W2912150716 hasAuthorship W2912150716A5063266058 @default.
- W2912150716 hasAuthorship W2912150716A5067068754 @default.
- W2912150716 hasAuthorship W2912150716A5072474961 @default.
- W2912150716 hasAuthorship W2912150716A5077881806 @default.
- W2912150716 hasAuthorship W2912150716A5085272133 @default.
- W2912150716 hasBestOaLocation W29121507162 @default.
- W2912150716 hasConcept C12554922 @default.
- W2912150716 hasConcept C126838900 @default.
- W2912150716 hasConcept C136229726 @default.
- W2912150716 hasConcept C143753070 @default.
- W2912150716 hasConcept C150903083 @default.
- W2912150716 hasConcept C171250308 @default.
- W2912150716 hasConcept C185592680 @default.
- W2912150716 hasConcept C192562407 @default.
- W2912150716 hasConcept C203014093 @default.
- W2912150716 hasConcept C207001950 @default.
- W2912150716 hasConcept C2779036427 @default.
- W2912150716 hasConcept C54173615 @default.
- W2912150716 hasConcept C55493867 @default.
- W2912150716 hasConcept C64012434 @default.
- W2912150716 hasConcept C71924100 @default.
- W2912150716 hasConcept C86803240 @default.
- W2912150716 hasConceptScore W2912150716C12554922 @default.
- W2912150716 hasConceptScore W2912150716C126838900 @default.
- W2912150716 hasConceptScore W2912150716C136229726 @default.
- W2912150716 hasConceptScore W2912150716C143753070 @default.
- W2912150716 hasConceptScore W2912150716C150903083 @default.
- W2912150716 hasConceptScore W2912150716C171250308 @default.
- W2912150716 hasConceptScore W2912150716C185592680 @default.
- W2912150716 hasConceptScore W2912150716C192562407 @default.