FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912151646> ?p ?o ?g. }

• W2912151646 abstract "Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease with an increasing global burden. It is hypothesized that fibroblasts have a number of functions that may affect the development and progression of IPF. However, the present understanding of cellular and molecular mechanisms associated with fibroblasts in IPF remains limited. The present study aimed to identify the dysregulated genes in IPF fibroblasts, elucidate their functions and explore potential microRNA (miRNA)‑mRNA interactions. mRNA and miRNA expression profiles were obtained from IPF fibroblasts and normal lung fibroblasts using a next‑generation sequencing platform, and bioinformatic analyses were performed in a step‑wise manner. A total of 42 dysregulated genes (>2 fold‑change of expression) were identified, of which 5 were verified in the Gene Expression Omnibus (GEO) database analysis, including the upregulation of neurotrimin (NTM), paired box 8 (PAX8) and mesoderm development LRP chaperone, and the downregulation of ITPR interacting domain containing 2 and Inka box actin regulator 2 (INKA2). Previous data indicated that PAX8 and INKA2 serve roles in cell growth, proliferation and survival. Gene Ontology analysis indicated that the most significant function of these 42 dysregulated genes was associated with the composition and function of the extracellular matrix (ECM). A total of 60 dysregulated miRNAs were also identified, and 1,908 targets were predicted by the miRmap database. The integrated analysis of mRNA and miRNA expression data, combined with GEO verification, finally identified Homo sapiens (hsa)‑miR‑1254‑INKA2 and hsa‑miR‑766‑3p‑INKA2 as the potential miRNA‑mRNA interactions in IPF fibroblasts. In summary, the results of the present study suggest that dysregulation of PAX8, hsa‑miR‑1254‑INKA2 and hsa‑miR‑766‑3p‑INKA2 may promote the proliferation and survival of IPF fibroblasts. In the functional analysis of the dysregulated genes, a marked association between fibroblasts and the ECM was identified. These data improve the current understanding of fibroblasts as key cells in the pathogenesis of IPF. As a screening study using bioinformatics approaches, the results of the present study require additional validation." @default.
• W2912151646 created "2019-02-21" @default.
• W2912151646 creator A5021011445 @default.
• W2912151646 creator A5027593926 @default.
• W2912151646 creator A5038085416 @default.
• W2912151646 creator A5059942361 @default.
• W2912151646 creator A5073595206 @default.
• W2912151646 creator A5081321440 @default.
• W2912151646 date "2019-01-31" @default.
• W2912151646 modified "2023-09-26" @default.
• W2912151646 title "Bioinformatic analysis of next‑generation sequencing data to identify dysregulated genes in fibroblasts of idiopathic pulmonary fibrosis" @default.
• W2912151646 cites W1826874877 @default.
• W2912151646 cites W1838105381 @default.
• W2912151646 cites W1970402401 @default.
• W2912151646 cites W1977157996 @default.
• W2912151646 cites W1980640149 @default.
• W2912151646 cites W1981533369 @default.
• W2912151646 cites W1985459638 @default.
• W2912151646 cites W1988272762 @default.
• W2912151646 cites W1990016474 @default.
• W2912151646 cites W2014739095 @default.
• W2912151646 cites W2015683287 @default.
• W2912151646 cites W2020541351 @default.
• W2912151646 cites W2025646149 @default.
• W2912151646 cites W2031123734 @default.
• W2912151646 cites W2037645843 @default.
• W2912151646 cites W2041588050 @default.
• W2912151646 cites W2045803078 @default.
• W2912151646 cites W2051666860 @default.
• W2912151646 cites W2054457017 @default.
• W2912151646 cites W2055245602 @default.
• W2912151646 cites W2057869883 @default.
• W2912151646 cites W2075995228 @default.
• W2912151646 cites W2100305481 @default.
• W2912151646 cites W2102278945 @default.
• W2912151646 cites W2104766198 @default.
• W2912151646 cites W2114970103 @default.
• W2912151646 cites W2116352515 @default.
• W2912151646 cites W2120797879 @default.
• W2912151646 cites W2122958293 @default.
• W2912151646 cites W2128016314 @default.
• W2912151646 cites W2130305733 @default.
• W2912151646 cites W2131271579 @default.
• W2912151646 cites W2131360426 @default.
• W2912151646 cites W2133465414 @default.
• W2912151646 cites W2134629862 @default.
• W2912151646 cites W2145073891 @default.
• W2912151646 cites W2150185396 @default.
• W2912151646 cites W2151707050 @default.
• W2912151646 cites W2154295458 @default.
• W2912151646 cites W2158217645 @default.
• W2912151646 cites W2162143298 @default.
• W2912151646 cites W2162714010 @default.
• W2912151646 cites W2163805477 @default.
• W2912151646 cites W2163989802 @default.
• W2912151646 cites W2167383172 @default.
• W2912151646 cites W2167898988 @default.
• W2912151646 cites W2178394372 @default.
• W2912151646 cites W2268312303 @default.
• W2912151646 cites W2419045660 @default.
• W2912151646 cites W2564229868 @default.
• W2912151646 cites W2588611179 @default.
• W2912151646 cites W2617652974 @default.
• W2912151646 cites W2740524054 @default.
• W2912151646 cites W2741336198 @default.
• W2912151646 cites W2762514850 @default.
• W2912151646 cites W2773677769 @default.
• W2912151646 cites W2791214769 @default.
• W2912151646 cites W2793027246 @default.
• W2912151646 cites W2793166635 @default.
• W2912151646 cites W2799479598 @default.
• W2912151646 cites W2805771055 @default.
• W2912151646 cites W2885432230 @default.
• W2912151646 cites W2885652964 @default.
• W2912151646 cites W2885948165 @default.
• W2912151646 cites W2889197569 @default.
• W2912151646 cites W2889209983 @default.
• W2912151646 cites W3025714645 @default.
• W2912151646 doi "https://doi.org/10.3892/ijmm.2019.4086" @default.
• W2912151646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6414167" @default.
• W2912151646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30720061" @default.
• W2912151646 hasPublicationYear "2019" @default.
• W2912151646 type Work @default.
• W2912151646 sameAs 2912151646 @default.
• W2912151646 citedByCount "10" @default.
• W2912151646 countsByYear W29121516462019 @default.
• W2912151646 countsByYear W29121516462020 @default.
• W2912151646 countsByYear W29121516462021 @default.
• W2912151646 countsByYear W29121516462022 @default.
• W2912151646 countsByYear W29121516462023 @default.
• W2912151646 crossrefType "journal-article" @default.
• W2912151646 hasAuthorship W2912151646A5021011445 @default.
• W2912151646 hasAuthorship W2912151646A5027593926 @default.
• W2912151646 hasAuthorship W2912151646A5038085416 @default.
• W2912151646 hasAuthorship W2912151646A5059942361 @default.
• W2912151646 hasAuthorship W2912151646A5073595206 @default.
• W2912151646 hasAuthorship W2912151646A5081321440 @default.
• W2912151646 hasBestOaLocation W29121516461 @default.
• W2912151646 hasConcept C104317684 @default.
• W2912151646 hasConcept C126322002 @default.

• next