FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912154118> ?p ?o ?g. }

• W2912154118 endingPage "597" @default.
• W2912154118 startingPage "591" @default.
• W2912154118 abstract "Nicorandil (NIC) is a vasodilatory drug used to treat angina. However, its efficacy of cardioprotection in coronary microembolization (CME) is largely unknown. This study was undertaken to determine whether nicorandil pretreatment could attenuate myocardial apoptosis and improve cardiac function after CME in rats.Forty-five rats were randomly divided into a Sham group, a CME group and a CME + NIC (NIC) group (n = 15 per group). CME was established by injecting plastic microspheres (42 µm in diameter) into the left ventricle of the rats in all of the groups except the Sham group. The NIC group received nicorandil at 3 mg/kg per day for seven days before the operation. Cardiac function was assessed by echocardiography, the expression levels of cleaved caspase-9/8/3 were detected by Western blot, microinfarction area was measured by haematoxylin-basic fuchsin picric acid staining, and myocardial apoptosis was detected by TUNEL staining.Compared to that in the Sham group, cardiac function in the CME group was significantly decreased (P < 0.05). However, compared to the CME group, the NIC group showed improved cardiac function (P < 0.05). The expression levels of cleaved caspase-9/8/3 protein and myocardial apoptosis were dramatically increased in the CME group compared to those in the Sham group (P < 0.05), while the NIC pretreatment group had significantly decreased expression levels of cleaved caspase-9/8/3 protein as well as a decreased apoptotic rate (P < 0.05).NIC pretreatment inhibited CME-induced myocardial apoptosis and improved cardiac function through blockade of the mitochondrial and death receptor-mediated apoptotic pathways." @default.
• W2912154118 created "2019-02-21" @default.
• W2912154118 creator A5041038506 @default.
• W2912154118 creator A5066507571 @default.
• W2912154118 creator A5071139676 @default.
• W2912154118 creator A5075122308 @default.
• W2912154118 creator A5082257579 @default.
• W2912154118 creator A5086015556 @default.
• W2912154118 date "2018-09-28" @default.
• W2912154118 modified "2023-09-25" @default.
• W2912154118 title "Nicorandil pretreatment inhibits myocardial apoptosis and improves cardiac function after coronary microembolization in rats." @default.
• W2912154118 cites W1883307717 @default.
• W2912154118 cites W1912539338 @default.
• W2912154118 cites W1964636336 @default.
• W2912154118 cites W1971644907 @default.
• W2912154118 cites W1999808819 @default.
• W2912154118 cites W2004130137 @default.
• W2912154118 cites W2009766464 @default.
• W2912154118 cites W2018354113 @default.
• W2912154118 cites W2020789729 @default.
• W2912154118 cites W2023945992 @default.
• W2912154118 cites W2037563659 @default.
• W2912154118 cites W2049676913 @default.
• W2912154118 cites W2067606104 @default.
• W2912154118 cites W2079683778 @default.
• W2912154118 cites W2080276645 @default.
• W2912154118 cites W2092248444 @default.
• W2912154118 cites W2094456763 @default.
• W2912154118 cites W2099085329 @default.
• W2912154118 cites W2105935043 @default.
• W2912154118 cites W2107899461 @default.
• W2912154118 cites W2122974654 @default.
• W2912154118 cites W2160875888 @default.
• W2912154118 cites W2168338299 @default.
• W2912154118 cites W2238311254 @default.
• W2912154118 cites W2325682962 @default.
• W2912154118 cites W2408832362 @default.
• W2912154118 cites W2438110290 @default.
• W2912154118 cites W4213213858 @default.
• W2912154118 cites W4236487956 @default.
• W2912154118 cites W1986075940 @default.
• W2912154118 doi "https://doi.org/10.11909/j.issn.1671-5411.2018.09.002" @default.
• W2912154118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6188981" @default.
• W2912154118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30344543" @default.
• W2912154118 hasPublicationYear "2018" @default.
• W2912154118 type Work @default.
• W2912154118 sameAs 2912154118 @default.
• W2912154118 citedByCount "3" @default.
• W2912154118 countsByYear W29121541182020 @default.
• W2912154118 countsByYear W29121541182021 @default.
• W2912154118 crossrefType "journal-article" @default.
• W2912154118 hasAuthorship W2912154118A5041038506 @default.
• W2912154118 hasAuthorship W2912154118A5066507571 @default.
• W2912154118 hasAuthorship W2912154118A5071139676 @default.
• W2912154118 hasAuthorship W2912154118A5075122308 @default.
• W2912154118 hasAuthorship W2912154118A5082257579 @default.
• W2912154118 hasAuthorship W2912154118A5086015556 @default.
• W2912154118 hasConcept C111566952 @default.
• W2912154118 hasConcept C126322002 @default.
• W2912154118 hasConcept C164705383 @default.
• W2912154118 hasConcept C185592680 @default.
• W2912154118 hasConcept C190283241 @default.
• W2912154118 hasConcept C196795494 @default.
• W2912154118 hasConcept C204232928 @default.
• W2912154118 hasConcept C2778198053 @default.
• W2912154118 hasConcept C2778902376 @default.
• W2912154118 hasConcept C2778921608 @default.
• W2912154118 hasConcept C2779676291 @default.
• W2912154118 hasConcept C42219234 @default.
• W2912154118 hasConcept C500558357 @default.
• W2912154118 hasConcept C55493867 @default.
• W2912154118 hasConcept C71924100 @default.
• W2912154118 hasConceptScore W2912154118C111566952 @default.
• W2912154118 hasConceptScore W2912154118C126322002 @default.
• W2912154118 hasConceptScore W2912154118C164705383 @default.
• W2912154118 hasConceptScore W2912154118C185592680 @default.
• W2912154118 hasConceptScore W2912154118C190283241 @default.
• W2912154118 hasConceptScore W2912154118C196795494 @default.
• W2912154118 hasConceptScore W2912154118C204232928 @default.
• W2912154118 hasConceptScore W2912154118C2778198053 @default.
• W2912154118 hasConceptScore W2912154118C2778902376 @default.
• W2912154118 hasConceptScore W2912154118C2778921608 @default.
• W2912154118 hasConceptScore W2912154118C2779676291 @default.
• W2912154118 hasConceptScore W2912154118C42219234 @default.
• W2912154118 hasConceptScore W2912154118C500558357 @default.
• W2912154118 hasConceptScore W2912154118C55493867 @default.
• W2912154118 hasConceptScore W2912154118C71924100 @default.
• W2912154118 hasIssue "9" @default.
• W2912154118 hasLocation W29121541181 @default.
• W2912154118 hasOpenAccess W2912154118 @default.
• W2912154118 hasPrimaryLocation W29121541181 @default.
• W2912154118 hasRelatedWork W1969590842 @default.
• W2912154118 hasRelatedWork W2354537752 @default.
• W2912154118 hasRelatedWork W2360353963 @default.
• W2912154118 hasRelatedWork W2360932513 @default.
• W2912154118 hasRelatedWork W2361322758 @default.
• W2912154118 hasRelatedWork W2379251940 @default.
• W2912154118 hasRelatedWork W2393215099 @default.

• next