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• W2912154659 abstract "Aim and objectives: Natural products and derivatives of medicinal vegetation can play an important role to thecure tumor. The Present study was focused to determine the effect of Cornus mass L. extract on the induction ofapoptosis in AGS gastric carcinoma cell line in compared to L929 cells. Methods: In this experimental study, AGSand L929 cells were cultured and treated with different concentrations (0–10 mg/ml) of Cornus mass L. extract for 48and 72 hours. Cell proliferation was assessed by MTT assay. The optical density of the colored solution was quantifiedat 570 nm wavelengths by an ELISA Reader. Making use of the apoptosis detection kit of Annexin V-FITC, PI anddouble staining with Annexin V-FITC were carried out for flow cytometry investigations. Data were analyzed byANOVA. Variations with a P-value less than 0.05 were considered significant. Results: shows a noticeable deviationamong various concentrations of extract when cells were treated for 48, 72 h declined cell viability in AGS cell line incomparison L929 cell lines in a dose and time-dependent manner (P < 0.05). This extract also displayed approximatelyseveral-fold increased anti-cancer potency in AGS compared to L929 cells. The IC50 value in AGS cells (evaluatedafter 48,72h) of the extract against AGS cells was 5/44, 2/44 mg/ml (p≤0.05). The analysis results of flow cytometryindicated that apoptosis was induced by the extract in AGS cells treated, compared with L929 cells. Conclusion: Eachof our results implicates the reality that Cornus mass L. extract acts as a novel, potent inhibitor of cancer proliferationin in vitro. This may result in developing a promising therapeutic agent for the treatment of indole-sensitive cancers." @default.
• W2912154659 created "2019-02-21" @default.
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• W2912154659 date "2019-01-01" @default.
• W2912154659 modified "2023-09-27" @default.
• W2912154659 title "Evaluating of Induction of Apoptosis by Cornus mass L. Extract in the Gastric Carcinoma Cell Line (AGS)" @default.
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• W2912154659 doi "https://doi.org/10.31557/apjcp.2019.20.1.123" @default.
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