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- W2912155025 endingPage "289" @default.
- W2912155025 startingPage "278" @default.
- W2912155025 abstract "The discovery of small non-coding RNAs began an interesting era in cellular and molecular biology. To date, miRNAs are the best recognized non-coding RNAs for maintenance and differentiation of pluripotent stem cells including embryonic stem cells (ES), induced pluripotent stem cells (iPSC), and cancer stem cells. ES cells are defined by their ability to self-renew, teratoma formation, and to produce numerous types of differentiated cells. Dual capacity of ES cells for self-renewal and differentiation is controlled by specific interaction with the neighboring cells and intrinsic signaling pathways from the level of transcription to translation. The ES cells have been the suitable model for evaluating the function of non-coding RNAs and in specific miRNAs. So far, the general function of the miRNAs in ES cells has been assessed in mammalian and non-mammalian stem cells. Nowadays, the evolution of sequencing technology led to the discovery of numerous miRNAs in human and mouse ES cells that their expression levels significantly changes during proliferation and differentiation. Several miRNAs have been identified in ectoderm, mesoderm, and endoderm cells, as well. This review would focus on recent knowledge about the expression and functional roles of miRNAs in embryonic and lineage-specific stem cells. It also describes that miRNAs might have essential roles in orchestrating the Waddington's landscape structure during development." @default.
- W2912155025 created "2019-02-21" @default.
- W2912155025 creator A5020367370 @default.
- W2912155025 creator A5062326562 @default.
- W2912155025 creator A5069899769 @default.
- W2912155025 creator A5069973060 @default.
- W2912155025 creator A5076015613 @default.
- W2912155025 creator A5085191497 @default.
- W2912155025 date "2019-04-29" @default.
- W2912155025 modified "2023-09-26" @default.
- W2912155025 title "The Expression and Functional Roles of miRNAs in Embryonic and Lineage-Specific Stem Cells" @default.
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