FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912155515> ?p ?o ?g. }

• W2912155515 endingPage "336" @default.
• W2912155515 startingPage "328" @default.
• W2912155515 abstract "Regular bathing in the Blue Lagoon has beneficial effects on psoriasis. Previously, we showed that exopolysaccharides (EPS-Ca) secreted by Cyanobacterium aponinum, a dominating organism in the Blue Lagoon, increased IL-10 secretion by human dendritic cells (DCs). In addition, co-culturing allogeneic CD4+ T cells with DCs matured in the presence of EPS-Ca increased differentiation of T cells into T regulatory cells at the cost of the disease inducing Th17 cells. In the present study, EPS-Ca increased the proportion of DCs expressing CD141, a surface molecule linked to regulatory DCs, and the CD141+ cells secreted more IL-10 than the CD141− cells. EPS-Ca decreased T cell secretion of IL-17, IL-13 and IL-10 and the proportion of T cells expressing the activation marker CD69 that has also been linked to lymphocyte retention. In addition, EPS-Ca reduced keratinocyte secretion of CCL20 and CXCL10, chemokines implicated in recruitment of inflammatory cells. EPS-Ca decreased DC expression of Dectin-1/CLEC7A and SYK, keratinocyte expression of CLEC7A, SYK and CAMP (the gene for LL37), and T cell expression of phosphorylated Zap70. These results indicate that EPS-Ca may induce a regulatory phenotype of DCs, T cells that are less active/inflammatory and less prone to being retained in the skin, and keratinocytes that induce less recruitment of inflammatory cells to the skin and that these effects may be mediated by the effects of EPS-Ca on CLEC7A and SYK. Overall the results indicate that EPS-Ca may be involved in the beneficial effects psoriasis patients experience when bathing in the Blue Lagoon." @default.
• W2912155515 created "2019-02-21" @default.
• W2912155515 creator A5011993379 @default.
• W2912155515 creator A5020734267 @default.
• W2912155515 creator A5026305746 @default.
• W2912155515 creator A5038563501 @default.
• W2912155515 creator A5054567925 @default.
• W2912155515 date "2019-04-01" @default.
• W2912155515 modified "2023-10-18" @default.
• W2912155515 title "Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes" @default.
• W2912155515 cites W1548366779 @default.
• W2912155515 cites W1573720570 @default.
• W2912155515 cites W1986330156 @default.
• W2912155515 cites W2017341404 @default.
• W2912155515 cites W2022252236 @default.
• W2912155515 cites W2059723426 @default.
• W2912155515 cites W2063050091 @default.
• W2912155515 cites W2066925516 @default.
• W2912155515 cites W2080090843 @default.
• W2912155515 cites W2089783130 @default.
• W2912155515 cites W2092374642 @default.
• W2912155515 cites W2095712743 @default.
• W2912155515 cites W2108507050 @default.
• W2912155515 cites W2127144270 @default.
• W2912155515 cites W2132491932 @default.
• W2912155515 cites W2144250450 @default.
• W2912155515 cites W2154724678 @default.
• W2912155515 cites W2198803648 @default.
• W2912155515 cites W2408730462 @default.
• W2912155515 cites W2516695653 @default.
• W2912155515 cites W2579395322 @default.
• W2912155515 cites W2612782028 @default.
• W2912155515 cites W2774892237 @default.
• W2912155515 cites W2775788879 @default.
• W2912155515 doi "https://doi.org/10.1016/j.intimp.2019.01.044" @default.
• W2912155515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30772700" @default.
• W2912155515 hasPublicationYear "2019" @default.
• W2912155515 type Work @default.
• W2912155515 sameAs 2912155515 @default.
• W2912155515 citedByCount "12" @default.
• W2912155515 countsByYear W29121555152020 @default.
• W2912155515 countsByYear W29121555152021 @default.
• W2912155515 countsByYear W29121555152022 @default.
• W2912155515 countsByYear W29121555152023 @default.
• W2912155515 crossrefType "journal-article" @default.
• W2912155515 hasAuthorship W2912155515A5011993379 @default.
• W2912155515 hasAuthorship W2912155515A5020734267 @default.
• W2912155515 hasAuthorship W2912155515A5026305746 @default.
• W2912155515 hasAuthorship W2912155515A5038563501 @default.
• W2912155515 hasAuthorship W2912155515A5054567925 @default.
• W2912155515 hasConcept C12823836 @default.
• W2912155515 hasConcept C13373296 @default.
• W2912155515 hasConcept C154317977 @default.
• W2912155515 hasConcept C185592680 @default.
• W2912155515 hasConcept C202751555 @default.
• W2912155515 hasConcept C203014093 @default.
• W2912155515 hasConcept C2776090121 @default.
• W2912155515 hasConcept C2777074287 @default.
• W2912155515 hasConcept C2778170410 @default.
• W2912155515 hasConcept C35174551 @default.
• W2912155515 hasConcept C39347974 @default.
• W2912155515 hasConcept C42362537 @default.
• W2912155515 hasConcept C49039625 @default.
• W2912155515 hasConcept C54355233 @default.
• W2912155515 hasConcept C55493867 @default.
• W2912155515 hasConcept C62478195 @default.
• W2912155515 hasConcept C67662055 @default.
• W2912155515 hasConcept C81885089 @default.
• W2912155515 hasConcept C83360876 @default.
• W2912155515 hasConcept C86803240 @default.
• W2912155515 hasConcept C8891405 @default.
• W2912155515 hasConcept C95444343 @default.
• W2912155515 hasConceptScore W2912155515C12823836 @default.
• W2912155515 hasConceptScore W2912155515C13373296 @default.
• W2912155515 hasConceptScore W2912155515C154317977 @default.
• W2912155515 hasConceptScore W2912155515C185592680 @default.
• W2912155515 hasConceptScore W2912155515C202751555 @default.
• W2912155515 hasConceptScore W2912155515C203014093 @default.
• W2912155515 hasConceptScore W2912155515C2776090121 @default.
• W2912155515 hasConceptScore W2912155515C2777074287 @default.
• W2912155515 hasConceptScore W2912155515C2778170410 @default.
• W2912155515 hasConceptScore W2912155515C35174551 @default.
• W2912155515 hasConceptScore W2912155515C39347974 @default.
• W2912155515 hasConceptScore W2912155515C42362537 @default.
• W2912155515 hasConceptScore W2912155515C49039625 @default.
• W2912155515 hasConceptScore W2912155515C54355233 @default.
• W2912155515 hasConceptScore W2912155515C55493867 @default.
• W2912155515 hasConceptScore W2912155515C62478195 @default.
• W2912155515 hasConceptScore W2912155515C67662055 @default.
• W2912155515 hasConceptScore W2912155515C81885089 @default.
• W2912155515 hasConceptScore W2912155515C83360876 @default.
• W2912155515 hasConceptScore W2912155515C86803240 @default.
• W2912155515 hasConceptScore W2912155515C8891405 @default.
• W2912155515 hasConceptScore W2912155515C95444343 @default.
• W2912155515 hasFunder F4320321020 @default.
• W2912155515 hasFunder F4320322367 @default.
• W2912155515 hasFunder F4320323298 @default.
• W2912155515 hasLocation W29121555151 @default.

• next