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• W2912157243 endingPage "e0212293" @default.
• W2912157243 startingPage "e0212293" @default.
• W2912157243 abstract "Objective To determine whether classes of diabetes medications are associated with cognitive health and dementia risk, above and beyond their glycemic control properties. Research design and methods Findings were pooled from 5 population-based cohorts: the Framingham Heart Study, the Rotterdam Study, the Atherosclerosis Risk in Communities (ARIC) Study, the Aging Gene-Environment Susceptibility-Reykjavik Study (AGES) and the Sacramento Area Latino Study on Aging (SALSA). Differences between users and non-users of insulin, metformin and sulfonylurea were assessed in each cohort for cognitive and brain MRI measures using linear regression models, and cognitive decline and dementia/AD risk using mixed effect models and Cox regression analyses, respectively. Findings were then pooled using meta-analytic techniques, including 3,590 individuals with diabetes for the prospective analysis. Results After adjusting for potential confounders including indices of glycemic control, insulin use was associated with increased risk of new-onset dementia (pooled HR (95% CI) = 1.58 (1.18, 2.12);p = 0.002) and with a greater decline in global cognitive function (β = -0.014±0.007;p = 0.045). The associations with incident dementia remained similar after further adjustment for renal function and excluding persons with diabetes whose treatment was life-style change only. Insulin use was not related to cognitive function nor to brain MRI measures. No significant associations were found between metformin or sulfonylurea use and outcomes of brain function and structure. There was no evidence of significant between-study heterogeneity. Conclusions Despite its advantages in controlling glycemic dysregulation and preventing complications, insulin treatment may be associated with increased adverse cognitive outcomes possibly due to a greater risk of hypoglycemia." @default.
• W2912157243 created "2019-02-21" @default.
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• W2912157243 date "2019-02-15" @default.
• W2912157243 modified "2023-10-16" @default.
• W2912157243 title "Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts" @default.
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• W2912157243 cites W1597817261 @default.
• W2912157243 cites W1970779072 @default.
• W2912157243 cites W1986628483 @default.
• W2912157243 cites W1988821503 @default.
• W2912157243 cites W1992934050 @default.
• W2912157243 cites W1998177554 @default.
• W2912157243 cites W1999288550 @default.
• W2912157243 cites W2000081470 @default.
• W2912157243 cites W2001599368 @default.
• W2912157243 cites W2002257186 @default.
• W2912157243 cites W2015202736 @default.
• W2912157243 cites W2018152164 @default.
• W2912157243 cites W2021446295 @default.
• W2912157243 cites W2027353223 @default.
• W2912157243 cites W2035873080 @default.
• W2912157243 cites W2043381283 @default.
• W2912157243 cites W2045441711 @default.
• W2912157243 cites W2057920800 @default.
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• W2912157243 cites W2096070750 @default.
• W2912157243 cites W2097594110 @default.
• W2912157243 cites W2105174200 @default.
• W2912157243 cites W2105180955 @default.
• W2912157243 cites W2115653936 @default.
• W2912157243 cites W2119494733 @default.
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• W2912157243 cites W2153399820 @default.
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• W2912157243 cites W2157534230 @default.
• W2912157243 cites W2158210081 @default.
• W2912157243 cites W2165563030 @default.
• W2912157243 cites W2171294019 @default.
• W2912157243 cites W2315843281 @default.
• W2912157243 cites W2338965349 @default.
• W2912157243 cites W2512316306 @default.
• W2912157243 cites W2522032327 @default.
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• W2912157243 doi "https://doi.org/10.1371/journal.pone.0212293" @default.
• W2912157243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6377188" @default.
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• W2912157243 hasPublicationYear "2019" @default.
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