Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912157454> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2912157454 abstract "Keratinocyte growth factor -2 promotes corneal repair. Its mechanism of action involves regulating regeneration and migration of corneal cells, as well as activating corneal limbal stem cells. However, KGF-2 being a carcinogenic growth factor and its potential adverse effect in over dosage long-term treatment had not yet been reported. In this study, we used New Zealand white rabbits to study possible toxic effects of ocular administration of recombinant human keratinocyte growth factor-2 eye drops. Animals in the medium- and high-dose groups had some ocular irritant reactions during the course of drug administration; however this reaction was harmless to the cornea and it ended up when administration was stopped. Serum biochemistries were largely unaffected by treatment. Pathological examinations were unremarkable. We found that over-dosed administration of these eye drops caused some ocular irritation, but this irritant reaction was harmless to the eye, and it reversed after the drug was stopped. There were no apparent systemic effects of the drug." @default.
- W2912157454 created "2019-02-21" @default.
- W2912157454 creator A5011060290 @default.
- W2912157454 creator A5014656305 @default.
- W2912157454 creator A5016494270 @default.
- W2912157454 creator A5019769795 @default.
- W2912157454 creator A5040919805 @default.
- W2912157454 creator A5045601651 @default.
- W2912157454 creator A5063065392 @default.
- W2912157454 creator A5090121857 @default.
- W2912157454 date "2019-04-01" @default.
- W2912157454 modified "2023-09-24" @default.
- W2912157454 title "Toxicology study of long-term administration of rhKGF-2 eye drops on rabbit corneas" @default.
- W2912157454 cites W1529641337 @default.
- W2912157454 cites W2018009819 @default.
- W2912157454 cites W2019299670 @default.
- W2912157454 cites W2062109784 @default.
- W2912157454 cites W2082514775 @default.
- W2912157454 cites W2115125970 @default.
- W2912157454 cites W2409918129 @default.
- W2912157454 cites W2519527699 @default.
- W2912157454 cites W270419267 @default.
- W2912157454 cites W2895060212 @default.
- W2912157454 cites W2116224782 @default.
- W2912157454 doi "https://doi.org/10.1016/j.yrtph.2019.02.002" @default.
- W2912157454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30735698" @default.
- W2912157454 hasPublicationYear "2019" @default.
- W2912157454 type Work @default.
- W2912157454 sameAs 2912157454 @default.
- W2912157454 citedByCount "3" @default.
- W2912157454 countsByYear W29121574542021 @default.
- W2912157454 countsByYear W29121574542022 @default.
- W2912157454 crossrefType "journal-article" @default.
- W2912157454 hasAuthorship W2912157454A5011060290 @default.
- W2912157454 hasAuthorship W2912157454A5014656305 @default.
- W2912157454 hasAuthorship W2912157454A5016494270 @default.
- W2912157454 hasAuthorship W2912157454A5019769795 @default.
- W2912157454 hasAuthorship W2912157454A5040919805 @default.
- W2912157454 hasAuthorship W2912157454A5045601651 @default.
- W2912157454 hasAuthorship W2912157454A5063065392 @default.
- W2912157454 hasAuthorship W2912157454A5090121857 @default.
- W2912157454 hasConcept C118487528 @default.
- W2912157454 hasConcept C126322002 @default.
- W2912157454 hasConcept C150903083 @default.
- W2912157454 hasConcept C170493617 @default.
- W2912157454 hasConcept C203014093 @default.
- W2912157454 hasConcept C207001950 @default.
- W2912157454 hasConcept C25938499 @default.
- W2912157454 hasConcept C2775960820 @default.
- W2912157454 hasConcept C2775984611 @default.
- W2912157454 hasConcept C2776882836 @default.
- W2912157454 hasConcept C2777063393 @default.
- W2912157454 hasConcept C2778615670 @default.
- W2912157454 hasConcept C2779257441 @default.
- W2912157454 hasConcept C2780035454 @default.
- W2912157454 hasConcept C29730261 @default.
- W2912157454 hasConcept C2994251472 @default.
- W2912157454 hasConcept C71924100 @default.
- W2912157454 hasConcept C86803240 @default.
- W2912157454 hasConcept C98274493 @default.
- W2912157454 hasConceptScore W2912157454C118487528 @default.
- W2912157454 hasConceptScore W2912157454C126322002 @default.
- W2912157454 hasConceptScore W2912157454C150903083 @default.
- W2912157454 hasConceptScore W2912157454C170493617 @default.
- W2912157454 hasConceptScore W2912157454C203014093 @default.
- W2912157454 hasConceptScore W2912157454C207001950 @default.
- W2912157454 hasConceptScore W2912157454C25938499 @default.
- W2912157454 hasConceptScore W2912157454C2775960820 @default.
- W2912157454 hasConceptScore W2912157454C2775984611 @default.
- W2912157454 hasConceptScore W2912157454C2776882836 @default.
- W2912157454 hasConceptScore W2912157454C2777063393 @default.
- W2912157454 hasConceptScore W2912157454C2778615670 @default.
- W2912157454 hasConceptScore W2912157454C2779257441 @default.
- W2912157454 hasConceptScore W2912157454C2780035454 @default.
- W2912157454 hasConceptScore W2912157454C29730261 @default.
- W2912157454 hasConceptScore W2912157454C2994251472 @default.
- W2912157454 hasConceptScore W2912157454C71924100 @default.
- W2912157454 hasConceptScore W2912157454C86803240 @default.
- W2912157454 hasConceptScore W2912157454C98274493 @default.
- W2912157454 hasFunder F4320338464 @default.
- W2912157454 hasLocation W29121574541 @default.
- W2912157454 hasLocation W29121574542 @default.
- W2912157454 hasOpenAccess W2912157454 @default.
- W2912157454 hasPrimaryLocation W29121574541 @default.
- W2912157454 hasRelatedWork W2014035845 @default.
- W2912157454 hasRelatedWork W2061219967 @default.
- W2912157454 hasRelatedWork W2078815463 @default.
- W2912157454 hasRelatedWork W2103092771 @default.
- W2912157454 hasRelatedWork W2164179887 @default.
- W2912157454 hasRelatedWork W2365930112 @default.
- W2912157454 hasRelatedWork W2403669806 @default.
- W2912157454 hasRelatedWork W2413612097 @default.
- W2912157454 hasRelatedWork W2912157454 @default.
- W2912157454 hasRelatedWork W1601157234 @default.
- W2912157454 isParatext "false" @default.
- W2912157454 isRetracted "false" @default.
- W2912157454 magId "2912157454" @default.
- W2912157454 workType "article" @default.