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• W2912158017 abstract "Several investigators have used Chinese hamsters from our colony for experimental work, and results of various studies are reported. — The group of Dr. H.R.Hausler, who initiated the colony in Toronto, studied retinal changes in spontaneously diabetic animals and also in hamsters with the metahypophyseal type of diabetes, following serial injections of growth hormone and cortisone. Arteriolar and capillary aneurysms were found in about 30% of the animals with metahypophyseal diabetes, but only sporadically in spontaneously diabetic hamsters. — The group of Dr. K.Schöffling studied alterations of testicular tissue in biopsy material. Corresponding to the severity of the disease, spontaneously diabetic hamsters showed various degrees of inhibited spermatogenesis, resulting in a reduction of the thickness of the germinal epithelium and widening of the lumina of the seminiferous tubules. There was also a reduction in the number of Leydig cells. The overall histological picture resembled that of the testes of the diabetic human patient. — The group of Dr. J.Campbell measured concentrations of serum free fatty acids (FFA) in nondiabetic Chinese hamsters and found the levels 4 to 9 times higher (3 to 5mEq/l) than in dogs, rats and man, but similar to FFA levels of Syrian hamsters.Epididymal fat pads of rats and Chinese hamsters showed similar lipid contents, but the latter released more FFA into the incubation medium. Nonglycosuric hamsters were susceptible to the diabetogenic effect of cortisone, but not to ovine growth hormone. Cortisone was most effective in producing a high blood sugar and elevated serum insulin and FFA concentrations. — In our own laboratory, the concentration of glycoproteins in plasma and the mucopolysaccharide content of the skin were determined in nondiabetic, occasionally glycosuric and frankly diabetic hamsters. There was no difference amongst the three groups of animals with regard to either the immunoelectrophoretic pattern or the concentration of individual carbohydrate components of plasma proteins. Skins of diabetic hamsters contained more mucopolysaccharide in their ground substance than skins of nondiabetic animals of comparable age. Hamsters with a mean fasting blood sugar value of 60 mg% showed a uronic acid content of 579μg per g of dry tissue, whereas animals with a mean fasting blood sugar of 107 mg% had 822μg." @default.
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• W2912158017 date "1967-04-01" @default.
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• W2912158017 title "The colony of Chinese hamsters of the C. H. Best Institute" @default.
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• W2912158017 doi "https://doi.org/10.1007/bf01222181" @default.
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