FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912158592> ?p ?o ?g. }

• W2912158592 endingPage "10" @default.
• W2912158592 startingPage "1" @default.
• W2912158592 abstract "Three miR-34 family members (miR-34a, miR-34b, and miR-34c) are clustered on two different chromosomal loci, Mir34a and Mir34b/c. These miRNAs have identical seed sequences, which are predicted to target the same set of genes. However, miR-34a and miR-34c have different sets of negatively correlated genes in lung adenocarcinoma data from The Cancer Genome Atlas. Therefore, we hypothesized that the individual miR-34 family members, which are tumor suppressive miRNAs, would have varying effects on lung tumorigenesis. To show this, we overexpressed each miR-34 cluster in murine lung cancer cells. MiR-34b/c enhanced cancer cell attachment and suppressed cell growth and invasion compared with miR-34a. In a syngeneic mouse model, both miR-34a and miR-34b/c blocked lung metastasis. However, miR-34b/c suppressed tumor growth more than miR-34a. MiR-34b/c also decreased the expression of mesenchymal markers (Cdh2 and Fn1) and increased the expression of epithelial markers (Cldn3, Dsp, and miR-200) to a greater degree than miR-34a. These results imply that miR-34b and miR-34c inhibit epithelial-to-mesenchymal transition. Furthermore, knockout of all three miR-34 members promoted mutant Kras-driven lung tumor progression in mice. Similarly, lung adenocarcinoma patients with higher miR-34a/b/c levels had better survival rates than did those with lower levels. In summary, we suggest that miR-34b and miR-34c are more effective tumor suppressors than miR-34a." @default.
• W2912158592 created "2019-02-21" @default.
• W2912158592 creator A5003463853 @default.
• W2912158592 creator A5003719092 @default.
• W2912158592 creator A5021687717 @default.
• W2912158592 creator A5022253992 @default.
• W2912158592 creator A5024102520 @default.
• W2912158592 creator A5031083361 @default.
• W2912158592 creator A5035847757 @default.
• W2912158592 creator A5055800505 @default.
• W2912158592 creator A5065839430 @default.
• W2912158592 creator A5076585994 @default.
• W2912158592 creator A5077871290 @default.
• W2912158592 date "2019-01-01" @default.
• W2912158592 modified "2023-10-16" @default.
• W2912158592 title "MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas" @default.
• W2912158592 cites W1974254202 @default.
• W2912158592 cites W1993799748 @default.
• W2912158592 cites W1994772304 @default.
• W2912158592 cites W2019310886 @default.
• W2912158592 cites W2037647570 @default.
• W2912158592 cites W2047355421 @default.
• W2912158592 cites W2054011804 @default.
• W2912158592 cites W2063878022 @default.
• W2912158592 cites W2069795758 @default.
• W2912158592 cites W2070765029 @default.
• W2912158592 cites W2083381199 @default.
• W2912158592 cites W2085252210 @default.
• W2912158592 cites W2087397570 @default.
• W2912158592 cites W2102059693 @default.
• W2912158592 cites W2120456037 @default.
• W2912158592 cites W2135249598 @default.
• W2912158592 cites W2148205338 @default.
• W2912158592 cites W2154589460 @default.
• W2912158592 cites W2155649150 @default.
• W2912158592 cites W2171166306 @default.
• W2912158592 cites W2184867100 @default.
• W2912158592 cites W2468025612 @default.
• W2912158592 cites W2558790575 @default.
• W2912158592 cites W2588025094 @default.
• W2912158592 cites W2603942390 @default.
• W2912158592 cites W2790409288 @default.
• W2912158592 doi "https://doi.org/10.1038/s12276-018-0203-1" @default.
• W2912158592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6353903" @default.
• W2912158592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700696" @default.
• W2912158592 hasPublicationYear "2019" @default.
• W2912158592 type Work @default.
• W2912158592 sameAs 2912158592 @default.
• W2912158592 citedByCount "40" @default.
• W2912158592 countsByYear W29121585922019 @default.
• W2912158592 countsByYear W29121585922020 @default.
• W2912158592 countsByYear W29121585922021 @default.
• W2912158592 countsByYear W29121585922022 @default.
• W2912158592 countsByYear W29121585922023 @default.
• W2912158592 crossrefType "journal-article" @default.
• W2912158592 hasAuthorship W2912158592A5003463853 @default.
• W2912158592 hasAuthorship W2912158592A5003719092 @default.
• W2912158592 hasAuthorship W2912158592A5021687717 @default.
• W2912158592 hasAuthorship W2912158592A5022253992 @default.
• W2912158592 hasAuthorship W2912158592A5024102520 @default.
• W2912158592 hasAuthorship W2912158592A5031083361 @default.
• W2912158592 hasAuthorship W2912158592A5035847757 @default.
• W2912158592 hasAuthorship W2912158592A5055800505 @default.
• W2912158592 hasAuthorship W2912158592A5065839430 @default.
• W2912158592 hasAuthorship W2912158592A5076585994 @default.
• W2912158592 hasAuthorship W2912158592A5077871290 @default.
• W2912158592 hasBestOaLocation W29121585921 @default.
• W2912158592 hasConcept C104317684 @default.
• W2912158592 hasConcept C121608353 @default.
• W2912158592 hasConcept C126322002 @default.
• W2912158592 hasConcept C143998085 @default.
• W2912158592 hasConcept C145059251 @default.
• W2912158592 hasConcept C2776256026 @default.
• W2912158592 hasConcept C2777714996 @default.
• W2912158592 hasConcept C2779013556 @default.
• W2912158592 hasConcept C2781182431 @default.
• W2912158592 hasConcept C2781187634 @default.
• W2912158592 hasConcept C501734568 @default.
• W2912158592 hasConcept C502942594 @default.
• W2912158592 hasConcept C54355233 @default.
• W2912158592 hasConcept C555283112 @default.
• W2912158592 hasConcept C71924100 @default.
• W2912158592 hasConcept C76419328 @default.
• W2912158592 hasConcept C86803240 @default.
• W2912158592 hasConceptScore W2912158592C104317684 @default.
• W2912158592 hasConceptScore W2912158592C121608353 @default.
• W2912158592 hasConceptScore W2912158592C126322002 @default.
• W2912158592 hasConceptScore W2912158592C143998085 @default.
• W2912158592 hasConceptScore W2912158592C145059251 @default.
• W2912158592 hasConceptScore W2912158592C2776256026 @default.
• W2912158592 hasConceptScore W2912158592C2777714996 @default.
• W2912158592 hasConceptScore W2912158592C2779013556 @default.
• W2912158592 hasConceptScore W2912158592C2781182431 @default.
• W2912158592 hasConceptScore W2912158592C2781187634 @default.
• W2912158592 hasConceptScore W2912158592C501734568 @default.
• W2912158592 hasConceptScore W2912158592C502942594 @default.
• W2912158592 hasConceptScore W2912158592C54355233 @default.
• W2912158592 hasConceptScore W2912158592C555283112 @default.

• next