FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912161778> ?p ?o ?g. }

• W2912161778 abstract "The BCR-ABL fusion gene (BCR-ABL) has different subtypes such as p210 and p190 with p190 appear to lead to a worse prognosis. To explore the mechanism of difference in pathogenesis and prognosis in different BCR-ABL subtype-related leukemia, expression profile microarray analysis was conducted between p190 and p210 patients and verified by RT-PCR. The p21-activated kinase (PAK1) gene was chosen and regulation of the PAK1-STAT5 biological axis and its influence on proliferation and apoptosis in leukemia cells were also analyzed. The results showed that PAK1 might be an important molecular mechanism of the pathogenic difference between different BCR-ABL subtypes. In P210 (+) chronic myelogenous leukemia (CML), down-regulated PAK1 gene expressions may lead to the suppression of cell proliferation and promotion of apoptosis through phosphorylation of STAT5, with a reverse effect in P190 (+) acute lymphoblastic leukemia(ALL), especially acute B lymphoblastic leukemia (B-ALL). Additionally, in P210 (+) CML, down-regulated PAK1 expression may enhance the effect of TKI, whereas the reverse is true in P190 (+) B-ALL, demonstrating that PAK1 might also be an important therapeutic target between different BCR-ABL subtypes." @default.
• W2912161778 created "2019-02-21" @default.
• W2912161778 creator A5000693841 @default.
• W2912161778 creator A5001106926 @default.
• W2912161778 creator A5004854548 @default.
• W2912161778 creator A5039298853 @default.
• W2912161778 creator A5067847652 @default.
• W2912161778 creator A5076563235 @default.
• W2912161778 creator A5079586899 @default.
• W2912161778 creator A5079891597 @default.
• W2912161778 creator A5083527291 @default.
• W2912161778 creator A5086385437 @default.
• W2912161778 creator A5089287034 @default.
• W2912161778 date "2019-04-01" @default.
• W2912161778 modified "2023-09-24" @default.
• W2912161778 title "Pak1 gene functioned differentially in different BCR-ABL subtypes in leukemiagenesis and treatment response through STAT5 pathway" @default.
• W2912161778 cites W134055875 @default.
• W2912161778 cites W1701936593 @default.
• W2912161778 cites W1964358866 @default.
• W2912161778 cites W2014644181 @default.
• W2912161778 cites W2033351987 @default.
• W2912161778 cites W2044499590 @default.
• W2912161778 cites W2066214252 @default.
• W2912161778 cites W2067677546 @default.
• W2912161778 cites W2070394392 @default.
• W2912161778 cites W2071274119 @default.
• W2912161778 cites W2076414341 @default.
• W2912161778 cites W2079517866 @default.
• W2912161778 cites W2092045262 @default.
• W2912161778 cites W2101217932 @default.
• W2912161778 cites W2102185138 @default.
• W2912161778 cites W2119768651 @default.
• W2912161778 cites W2120508074 @default.
• W2912161778 cites W2121327804 @default.
• W2912161778 cites W2123934866 @default.
• W2912161778 cites W2160969394 @default.
• W2912161778 cites W2162801973 @default.
• W2912161778 cites W2166641737 @default.
• W2912161778 cites W2167630501 @default.
• W2912161778 cites W2207680991 @default.
• W2912161778 cites W2330517068 @default.
• W2912161778 cites W2580750923 @default.
• W2912161778 cites W4298710699 @default.
• W2912161778 doi "https://doi.org/10.1016/j.leukres.2019.01.012" @default.
• W2912161778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30784762" @default.
• W2912161778 hasPublicationYear "2019" @default.
• W2912161778 type Work @default.
• W2912161778 sameAs 2912161778 @default.
• W2912161778 citedByCount "3" @default.
• W2912161778 countsByYear W29121617782020 @default.
• W2912161778 countsByYear W29121617782021 @default.
• W2912161778 countsByYear W29121617782023 @default.
• W2912161778 crossrefType "journal-article" @default.
• W2912161778 hasAuthorship W2912161778A5000693841 @default.
• W2912161778 hasAuthorship W2912161778A5001106926 @default.
• W2912161778 hasAuthorship W2912161778A5004854548 @default.
• W2912161778 hasAuthorship W2912161778A5039298853 @default.
• W2912161778 hasAuthorship W2912161778A5067847652 @default.
• W2912161778 hasAuthorship W2912161778A5076563235 @default.
• W2912161778 hasAuthorship W2912161778A5079586899 @default.
• W2912161778 hasAuthorship W2912161778A5079891597 @default.
• W2912161778 hasAuthorship W2912161778A5083527291 @default.
• W2912161778 hasAuthorship W2912161778A5086385437 @default.
• W2912161778 hasAuthorship W2912161778A5089287034 @default.
• W2912161778 hasConcept C104317684 @default.
• W2912161778 hasConcept C111829193 @default.
• W2912161778 hasConcept C11960822 @default.
• W2912161778 hasConcept C125418893 @default.
• W2912161778 hasConcept C150194340 @default.
• W2912161778 hasConcept C171122931 @default.
• W2912161778 hasConcept C18431079 @default.
• W2912161778 hasConcept C186836561 @default.
• W2912161778 hasConcept C203014093 @default.
• W2912161778 hasConcept C24901178 @default.
• W2912161778 hasConcept C2776960273 @default.
• W2912161778 hasConcept C2778461978 @default.
• W2912161778 hasConcept C2779391668 @default.
• W2912161778 hasConcept C42362537 @default.
• W2912161778 hasConcept C43907098 @default.
• W2912161778 hasConcept C502942594 @default.
• W2912161778 hasConcept C54355233 @default.
• W2912161778 hasConcept C62478195 @default.
• W2912161778 hasConcept C86803240 @default.
• W2912161778 hasConcept C95444343 @default.
• W2912161778 hasConceptScore W2912161778C104317684 @default.
• W2912161778 hasConceptScore W2912161778C111829193 @default.
• W2912161778 hasConceptScore W2912161778C11960822 @default.
• W2912161778 hasConceptScore W2912161778C125418893 @default.
• W2912161778 hasConceptScore W2912161778C150194340 @default.
• W2912161778 hasConceptScore W2912161778C171122931 @default.
• W2912161778 hasConceptScore W2912161778C18431079 @default.
• W2912161778 hasConceptScore W2912161778C186836561 @default.
• W2912161778 hasConceptScore W2912161778C203014093 @default.
• W2912161778 hasConceptScore W2912161778C24901178 @default.
• W2912161778 hasConceptScore W2912161778C2776960273 @default.
• W2912161778 hasConceptScore W2912161778C2778461978 @default.
• W2912161778 hasConceptScore W2912161778C2779391668 @default.
• W2912161778 hasConceptScore W2912161778C42362537 @default.
• W2912161778 hasConceptScore W2912161778C43907098 @default.
• W2912161778 hasConceptScore W2912161778C502942594 @default.

• next