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- W2912161815 abstract "Dietary polyphenols are known to exert health benefits through modulation of signaling networks. This study investigated the modulation of micro-RNAs associated with the PI3K/AKT/mTOR-axis by mango polyphenols (MP) in MCF-12A non-cancer and MDA-MB231 breast cancer cell lines. MP reduced proliferation in the cancer cells by up to 90% (10 mg GAE/L) but did not cause cytotoxicity in the non-cancer cells within the same concentration range. In contrast, in TNF-α-treated non-cancer MCF-12A cells, MP significantly decreased expression and phosphorylation of NF-κB while modulating mRNA and protein levels of PI3K/AKT/mTOR and up-regulated miR-126. The mechanistic involvement of miR-126 was investigated using its antagomiR. In MDA-MB231 cells, miR-126 was not affected. However, polyphenols modulated the PI3K/AKT/mTOR-axis and down-regulated miR-21 while the expressions of NF-κB and biomarkers for inhibition of apoptosis, namely, PARP-1 and Bcl-2 decreased. Overall, MP reduced inflammation in non-cancer and proliferation in breast cancer cells by differentially modulating PI3K/AKT/mTOR and associated micro-RNAs." @default.
- W2912161815 created "2019-02-21" @default.
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- W2912161815 date "2019-04-01" @default.
- W2912161815 modified "2023-09-25" @default.
- W2912161815 title "Polyphenols from mango (Mangifera indica L.) modulate PI3K/AKT/mTOR-associated micro-RNAs and reduce inflammation in non-cancer and induce cell death in breast cancer cells" @default.
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- W2912161815 doi "https://doi.org/10.1016/j.jff.2019.01.035" @default.
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