Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912162117> ?p ?o ?g. }
- W2912162117 endingPage "484" @default.
- W2912162117 startingPage "484" @default.
- W2912162117 abstract "New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral compounds were separated into their single enantiomers and tested. The impact of the substituents at N1, C3 and C5 positions as well the influence of the configuration of the C5 on the biological activity were analyzed. Bulky aromatic groups at C5 were not tolerated. p-Prenyloxyaryl moiety at C3 oriented the selectivity toward the B isoform. The results were also corroborated by molecular modelling studies providing new suggestions for the synthesis of privileged structures to serve as lead compounds for the treatment of mood disorders and neurodegenerative diseases." @default.
- W2912162117 created "2019-02-21" @default.
- W2912162117 creator A5001749285 @default.
- W2912162117 creator A5010249495 @default.
- W2912162117 creator A5030450621 @default.
- W2912162117 creator A5031749522 @default.
- W2912162117 creator A5032602173 @default.
- W2912162117 creator A5042899314 @default.
- W2912162117 creator A5047249553 @default.
- W2912162117 creator A5068255593 @default.
- W2912162117 creator A5079529603 @default.
- W2912162117 date "2019-01-29" @default.
- W2912162117 modified "2023-09-25" @default.
- W2912162117 title "Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles" @default.
- W2912162117 cites W1968928564 @default.
- W2912162117 cites W1976038923 @default.
- W2912162117 cites W1992928390 @default.
- W2912162117 cites W1993758948 @default.
- W2912162117 cites W1998895449 @default.
- W2912162117 cites W2007696751 @default.
- W2912162117 cites W2027437464 @default.
- W2912162117 cites W2035982666 @default.
- W2912162117 cites W2036056925 @default.
- W2912162117 cites W2037061957 @default.
- W2912162117 cites W2042899403 @default.
- W2912162117 cites W2047544230 @default.
- W2912162117 cites W2049847177 @default.
- W2912162117 cites W2052001291 @default.
- W2912162117 cites W2056649543 @default.
- W2912162117 cites W2057458631 @default.
- W2912162117 cites W2079183404 @default.
- W2912162117 cites W2083714775 @default.
- W2912162117 cites W2088892561 @default.
- W2912162117 cites W2088993261 @default.
- W2912162117 cites W2103419617 @default.
- W2912162117 cites W2105668062 @default.
- W2912162117 cites W2109108051 @default.
- W2912162117 cites W2168326866 @default.
- W2912162117 cites W2282376138 @default.
- W2912162117 cites W2471726490 @default.
- W2912162117 cites W2605010348 @default.
- W2912162117 cites W2745176805 @default.
- W2912162117 cites W2783421922 @default.
- W2912162117 cites W2805497424 @default.
- W2912162117 cites W2807834367 @default.
- W2912162117 cites W2888417910 @default.
- W2912162117 cites W2891286994 @default.
- W2912162117 cites W2893481706 @default.
- W2912162117 cites W2900741301 @default.
- W2912162117 doi "https://doi.org/10.3390/molecules24030484" @default.
- W2912162117 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6384781" @default.
- W2912162117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700029" @default.
- W2912162117 hasPublicationYear "2019" @default.
- W2912162117 type Work @default.
- W2912162117 sameAs 2912162117 @default.
- W2912162117 citedByCount "21" @default.
- W2912162117 countsByYear W29121621172019 @default.
- W2912162117 countsByYear W29121621172020 @default.
- W2912162117 countsByYear W29121621172021 @default.
- W2912162117 countsByYear W29121621172022 @default.
- W2912162117 countsByYear W29121621172023 @default.
- W2912162117 crossrefType "journal-article" @default.
- W2912162117 hasAuthorship W2912162117A5001749285 @default.
- W2912162117 hasAuthorship W2912162117A5010249495 @default.
- W2912162117 hasAuthorship W2912162117A5030450621 @default.
- W2912162117 hasAuthorship W2912162117A5031749522 @default.
- W2912162117 hasAuthorship W2912162117A5032602173 @default.
- W2912162117 hasAuthorship W2912162117A5042899314 @default.
- W2912162117 hasAuthorship W2912162117A5047249553 @default.
- W2912162117 hasAuthorship W2912162117A5068255593 @default.
- W2912162117 hasAuthorship W2912162117A5079529603 @default.
- W2912162117 hasBestOaLocation W29121621171 @default.
- W2912162117 hasConcept C114461151 @default.
- W2912162117 hasConcept C118792377 @default.
- W2912162117 hasConcept C159110408 @default.
- W2912162117 hasConcept C161790260 @default.
- W2912162117 hasConcept C181199279 @default.
- W2912162117 hasConcept C185592680 @default.
- W2912162117 hasConcept C21951064 @default.
- W2912162117 hasConcept C2776024655 @default.
- W2912162117 hasConcept C2776568683 @default.
- W2912162117 hasConcept C39398028 @default.
- W2912162117 hasConcept C41685203 @default.
- W2912162117 hasConcept C486523 @default.
- W2912162117 hasConcept C55493867 @default.
- W2912162117 hasConcept C71240020 @default.
- W2912162117 hasConcept C71924100 @default.
- W2912162117 hasConceptScore W2912162117C114461151 @default.
- W2912162117 hasConceptScore W2912162117C118792377 @default.
- W2912162117 hasConceptScore W2912162117C159110408 @default.
- W2912162117 hasConceptScore W2912162117C161790260 @default.
- W2912162117 hasConceptScore W2912162117C181199279 @default.
- W2912162117 hasConceptScore W2912162117C185592680 @default.
- W2912162117 hasConceptScore W2912162117C21951064 @default.
- W2912162117 hasConceptScore W2912162117C2776024655 @default.
- W2912162117 hasConceptScore W2912162117C2776568683 @default.
- W2912162117 hasConceptScore W2912162117C39398028 @default.
- W2912162117 hasConceptScore W2912162117C41685203 @default.