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- W2912162534 endingPage "98" @default.
- W2912162534 startingPage "87" @default.
- W2912162534 abstract "Ocular neovascular diseases are featured by abnormal angiogenesis in the eye, and they seriously threaten the human visual health. These diseases include proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and retinal vein occlusion (RVO). In fact, ocular neovascular diseases represent the leading causes of vision impairment and blindness worldwide. Ocular neovascularization, the process of pathological vessel formation in eye, underlies ocular neovascular diseases. Cytokines have important regulatory roles in neovascularization through immunological networks. Interleukin (IL)-17, the signature cytokine produced by T helper 17 (Th17) cells, has proven to be involved in ocular neovascularization. However, roles of IL-17 in ocular neovascular diseases still remain controversial. This review provides an overview of the functional roles of IL-17 in ocular neovascular diseases from basic research to clinical evidence by focusing on PDR, AMD, ROP, and RVO. The possible roles of IL-17 in neovascularization are achieved through a regulatory network of cytoskeleton remodeling, vascular endothelial growth factor (VEGF), VEGF-related cytokines, and complement components. Current applications as well as potential therapies targeting IL-17 with genome editing systems are also outlined and discussed. Targeting IL-17 might be a promising therapeutic strategy against ocular neovascular diseases." @default.
- W2912162534 created "2019-02-21" @default.
- W2912162534 creator A5054233848 @default.
- W2912162534 creator A5058570581 @default.
- W2912162534 date "2019-01-01" @default.
- W2912162534 modified "2023-10-09" @default.
- W2912162534 title "Interleukin-17: The Role for Pathological Angiogenesis in Ocular Neovascular Diseases" @default.
- W2912162534 cites W1505833426 @default.
- W2912162534 cites W1508752722 @default.
- W2912162534 cites W1555251831 @default.
- W2912162534 cites W1797422316 @default.
- W2912162534 cites W1856119395 @default.
- W2912162534 cites W1916893403 @default.
- W2912162534 cites W1917356573 @default.
- W2912162534 cites W1935908062 @default.
- W2912162534 cites W1966811228 @default.
- W2912162534 cites W1970246068 @default.
- W2912162534 cites W1977159392 @default.
- W2912162534 cites W1977781630 @default.
- W2912162534 cites W1978357942 @default.
- W2912162534 cites W1979934421 @default.
- W2912162534 cites W1982926364 @default.
- W2912162534 cites W1983081586 @default.
- W2912162534 cites W1984090235 @default.
- W2912162534 cites W1984131081 @default.
- W2912162534 cites W1992159395 @default.
- W2912162534 cites W1997026470 @default.
- W2912162534 cites W1998000193 @default.
- W2912162534 cites W2000102677 @default.
- W2912162534 cites W2001857046 @default.
- W2912162534 cites W2004186675 @default.
- W2912162534 cites W2004549544 @default.
- W2912162534 cites W2006072720 @default.
- W2912162534 cites W2011015208 @default.
- W2912162534 cites W2020209902 @default.
- W2912162534 cites W2020744745 @default.
- W2912162534 cites W2021409647 @default.
- W2912162534 cites W2022140485 @default.
- W2912162534 cites W2023164440 @default.
- W2912162534 cites W2023749167 @default.
- W2912162534 cites W2024490058 @default.
- W2912162534 cites W2027744674 @default.
- W2912162534 cites W2029119558 @default.
- W2912162534 cites W2029557435 @default.
- W2912162534 cites W2038981686 @default.
- W2912162534 cites W2044063309 @default.
- W2912162534 cites W2046388159 @default.
- W2912162534 cites W2047640394 @default.
- W2912162534 cites W2064268032 @default.
- W2912162534 cites W2065577291 @default.
- W2912162534 cites W2070715537 @default.
- W2912162534 cites W2070777085 @default.
- W2912162534 cites W2071205488 @default.
- W2912162534 cites W2079562810 @default.
- W2912162534 cites W2081063786 @default.
- W2912162534 cites W2084944408 @default.
- W2912162534 cites W2087377443 @default.
- W2912162534 cites W2087445453 @default.
- W2912162534 cites W2087466296 @default.
- W2912162534 cites W2093705034 @default.
- W2912162534 cites W2094894580 @default.
- W2912162534 cites W2104226707 @default.
- W2912162534 cites W2113034544 @default.
- W2912162534 cites W2118706017 @default.
- W2912162534 cites W2121438737 @default.
- W2912162534 cites W2123491780 @default.
- W2912162534 cites W2132154261 @default.
- W2912162534 cites W2143100947 @default.
- W2912162534 cites W2154583934 @default.
- W2912162534 cites W2155630596 @default.
- W2912162534 cites W2166456188 @default.
- W2912162534 cites W2171651020 @default.
- W2912162534 cites W2172316739 @default.
- W2912162534 cites W2191802148 @default.
- W2912162534 cites W2228449504 @default.
- W2912162534 cites W2262283913 @default.
- W2912162534 cites W2264982258 @default.
- W2912162534 cites W2266819431 @default.
- W2912162534 cites W2292240589 @default.
- W2912162534 cites W2299551279 @default.
- W2912162534 cites W2299883777 @default.
- W2912162534 cites W2322911088 @default.
- W2912162534 cites W2335382466 @default.
- W2912162534 cites W2341966417 @default.
- W2912162534 cites W2460114700 @default.
- W2912162534 cites W2472819017 @default.
- W2912162534 cites W2475139662 @default.
- W2912162534 cites W2518697266 @default.
- W2912162534 cites W2527404829 @default.
- W2912162534 cites W2556029117 @default.
- W2912162534 cites W2590029152 @default.
- W2912162534 cites W2600469220 @default.
- W2912162534 cites W2612207980 @default.
- W2912162534 cites W2614738659 @default.
- W2912162534 cites W2615787984 @default.
- W2912162534 cites W2617820979 @default.
- W2912162534 cites W2620385097 @default.
- W2912162534 cites W2744068958 @default.