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- W291216453 abstract "Focal and segmental glomerulosclerosis (FSGS) is a common cause of Nephrotic Syndrome in adults. Its most typical course runs from NS to progressive loss of renal function and may recur in the graft after renal transplantation. Current evidence favors prolonged corticosteroid therapy (6 months or longer) to induce remission of proteinuria. Steroid-dependent and steroid-resistant patients may benefit from treatment with cyclosporine or cyclophosphamide. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are effective in reducing proteinuria and are recommended in all patients with FSGS, particularly those with nonnephrotic proteinuria. FSGS can be idiopathic or secondary to glomerular hyperfiltration and high intraglomerular capillary pressure or to viral or toxin-mediated damage. The characteristic lesion is a segmental solidification of the glomerular tuft." @default.
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- W291216453 date "2008-01-01" @default.
- W291216453 modified "2023-09-26" @default.
- W291216453 title "Focal and Segmental Glomerulosclerosis" @default.
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