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- W2912164578 abstract "Potentially pandemic strains of influenza pose an undeniable threat to human populations. Therefore, it is essential to develop better strategies to enhance vaccine design and predict parameters that identify susceptible humans. CD4 T cells are a central component of protective immunity to influenza, delivering direct effector function and potentiating responses of other lymphoid cells. Humans have highly diverse influenza-specific CD4 T-cell populations that vary in stimulation history, specificity, and functionality. These complexities constitute a formidable obstacle to predicting immune responses to pandemic strains of influenza and derivation of optimal vaccine strategies. We suggest that more precise efforts to identify and enumerate both the positive and negative contributors of immunity in the CD4 T-cell compartment will aid in both predicting susceptible hosts and in development of vaccination strategies that will poise most human subjects to respond to pandemic influenza strains with protective immune responses." @default.
- W2912164578 created "2019-02-21" @default.
- W2912164578 creator A5074802230 @default.
- W2912164578 date "2019-04-08" @default.
- W2912164578 modified "2023-10-18" @default.
- W2912164578 title "The Way Forward: Potentiating Protective Immunity to Novel and Pandemic Influenza Through Engagement of Memory CD4 T Cells" @default.
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- W2912164578 doi "https://doi.org/10.1093/infdis/jiy666" @default.
- W2912164578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6452298" @default.
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- W2912164578 hasPublicationYear "2019" @default.
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