Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912164609> ?p ?o ?g. }
- W2912164609 endingPage "423" @default.
- W2912164609 startingPage "411" @default.
- W2912164609 abstract "Abstract In all domains of life, the regulation of transcription by DNA-dependent RNA polymerases (RNAPs) is achieved at the level of initiation to a large extent. Whereas bacterial promoters are recognized by a σ-factor bound to the RNAP, a complex set of transcription factors that recognize specific promoter elements is employed by archaeal and eukaryotic RNAPs. These initiation factors are of particular interest since the regulation of transcription critically relies on initiation rates and thus formation of pre-initiation complexes. The most conserved initiation factor is the TATA-binding protein (TBP), which is of crucial importance for all archaeal-eukaryotic transcription initiation complexes and the only factor required to achieve full rates of initiation in all three eukaryotic and the archaeal transcription systems. Recent structural, biochemical and genome-wide mapping data that focused on the archaeal and specialized RNAP I and III transcription system showed that the involvement and functional importance of TBP is divergent from the canonical role TBP plays in RNAP II transcription. Here, we review the role of TBP in the different transcription systems including a TBP-centric discussion of archaeal and eukaryotic initiation complexes. We furthermore highlight questions concerning the function of TBP that arise from these findings." @default.
- W2912164609 created "2019-02-21" @default.
- W2912164609 creator A5005665024 @default.
- W2912164609 creator A5047962510 @default.
- W2912164609 creator A5077005418 @default.
- W2912164609 date "2019-02-01" @default.
- W2912164609 modified "2023-10-14" @default.
- W2912164609 title "Transcription initiation factor TBP: old friend new questions" @default.
- W2912164609 cites W1264979566 @default.
- W2912164609 cites W1509357297 @default.
- W2912164609 cites W1514077182 @default.
- W2912164609 cites W1561042132 @default.
- W2912164609 cites W1601979992 @default.
- W2912164609 cites W1884135206 @default.
- W2912164609 cites W1896401624 @default.
- W2912164609 cites W1965700324 @default.
- W2912164609 cites W1968493087 @default.
- W2912164609 cites W1968764028 @default.
- W2912164609 cites W1970419053 @default.
- W2912164609 cites W1975251488 @default.
- W2912164609 cites W1979715288 @default.
- W2912164609 cites W1979992345 @default.
- W2912164609 cites W1980484671 @default.
- W2912164609 cites W1981278932 @default.
- W2912164609 cites W1983027084 @default.
- W2912164609 cites W1984891745 @default.
- W2912164609 cites W1985315760 @default.
- W2912164609 cites W1987109078 @default.
- W2912164609 cites W1988541338 @default.
- W2912164609 cites W1989451462 @default.
- W2912164609 cites W1992223935 @default.
- W2912164609 cites W1993050748 @default.
- W2912164609 cites W1995229527 @default.
- W2912164609 cites W1997481046 @default.
- W2912164609 cites W1999745373 @default.
- W2912164609 cites W2001469156 @default.
- W2912164609 cites W2001777629 @default.
- W2912164609 cites W2002107821 @default.
- W2912164609 cites W2004546827 @default.
- W2912164609 cites W2004733904 @default.
- W2912164609 cites W2006322387 @default.
- W2912164609 cites W2006630070 @default.
- W2912164609 cites W2007051444 @default.
- W2912164609 cites W2008619144 @default.
- W2912164609 cites W2009311720 @default.
- W2912164609 cites W2010118412 @default.
- W2912164609 cites W2012275883 @default.
- W2912164609 cites W2013202067 @default.
- W2912164609 cites W2016786878 @default.
- W2912164609 cites W2019954213 @default.
- W2912164609 cites W2020363034 @default.
- W2912164609 cites W2022101620 @default.
- W2912164609 cites W2022122087 @default.
- W2912164609 cites W2026015266 @default.
- W2912164609 cites W2027534342 @default.
- W2912164609 cites W2032864324 @default.
- W2912164609 cites W2033244846 @default.
- W2912164609 cites W2035546546 @default.
- W2912164609 cites W2035797443 @default.
- W2912164609 cites W2035828096 @default.
- W2912164609 cites W2037569268 @default.
- W2912164609 cites W2040940496 @default.
- W2912164609 cites W2042425655 @default.
- W2912164609 cites W2047538154 @default.
- W2912164609 cites W2053492846 @default.
- W2912164609 cites W2057153975 @default.
- W2912164609 cites W2057512960 @default.
- W2912164609 cites W2057692691 @default.
- W2912164609 cites W2058217073 @default.
- W2912164609 cites W2058349538 @default.
- W2912164609 cites W2059198116 @default.
- W2912164609 cites W2063296736 @default.
- W2912164609 cites W2063321023 @default.
- W2912164609 cites W2064311051 @default.
- W2912164609 cites W2065073949 @default.
- W2912164609 cites W2066833380 @default.
- W2912164609 cites W2067009740 @default.
- W2912164609 cites W2071802835 @default.
- W2912164609 cites W2072223289 @default.
- W2912164609 cites W2074206760 @default.
- W2912164609 cites W2074624482 @default.
- W2912164609 cites W2074841132 @default.
- W2912164609 cites W2077132193 @default.
- W2912164609 cites W2077219109 @default.
- W2912164609 cites W2078366770 @default.
- W2912164609 cites W2079557259 @default.
- W2912164609 cites W2080256344 @default.
- W2912164609 cites W2080531393 @default.
- W2912164609 cites W2080605954 @default.
- W2912164609 cites W2082319816 @default.
- W2912164609 cites W2082667898 @default.
- W2912164609 cites W2083842078 @default.
- W2912164609 cites W2084622414 @default.
- W2912164609 cites W2085616329 @default.
- W2912164609 cites W2090797443 @default.
- W2912164609 cites W2091187232 @default.
- W2912164609 cites W2093659250 @default.
- W2912164609 cites W2095254687 @default.