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• W2912165739 abstract "Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)–targeted ADCC were frequently identified in HIV-2–infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection." @default.
• W2912165739 created "2019-02-21" @default.
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• W2912165739 date "2019-02-02" @default.
• W2912165739 modified "2023-10-16" @default.
• W2912165739 title "Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein–Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2–Infected Individuals" @default.
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• W2912165739 doi "https://doi.org/10.1093/infdis/jiz001" @default.
• W2912165739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6500551" @default.
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