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- W2912166899 abstract "Purpose: The aims of this study were to evaluate the role of vacA genotyping with respect to gastric inflammation and injury, and clinical presentation in Iranian populations. Methods: Genomic DNA from biopsy specimens from patients with gastritis, peptic ulcer disease and gastric cancer were characterized by ureC (glmM), cagA and vacA genotyping by polymerase chain reaction (PCR). Results: Our results showed that 96 (57%) of 167 patients with gastro duodenal diseases, 19 of 33 gastroduodenal ulcer and 3(60%) of 5 gastric cancer were infected with H. pylori. In this study 19.8% strains were isolated from patients with PUD and 68.7% from patients with NUD.s1m2 genotype was observed in 36.8%, of PUD and 40.5% NUD patients. Conclusion: Prevalence of cagA positive (76%) in Iran is close to that of Europe and North America (60–70%) than Asian countries (90%). Regarding the vacA gene, 97% (93 of 96) of H. pylori positive patients determined by ureC (glmM) PCR were successfully detect the vacA gene. The vacA s1m2 was predominant genotype in Iran (41%). The prevalence of s2m1 (8.3%) was high in Iranian isolates. Although individuals who infected with H. pylori possessing the cagA (+) gene and vacA m2 genotypes were more sensitive to development of gastroduodenal disease but we could not find any significant correlation between cagA status and PUD, because of similar high cagA gene positivity in the H. pylori strains isolated from PUD (78.6%) and NUD (74.3%). CagA status cannot be used as a useful marker to predict the outcome of the infection in patients in Iran." @default.
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- W2912166899 date "2007-09-01" @default.
- W2912166899 modified "2023-10-18" @default.
- W2912166899 title "Clinical Outcomes of Helicobacter pylori Infection in Relation to vacA and cagA Genotypes in Iranian Patients" @default.
- W2912166899 doi "https://doi.org/10.14309/00000434-200709002-00879" @default.
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