Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912167963> ?p ?o ?g. }
- W2912167963 endingPage "917" @default.
- W2912167963 startingPage "905" @default.
- W2912167963 abstract "Abstract Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-species gene expression analyses classified SB-driven tumors into distinct medulloblastoma and CNS-PNET subgroups, indicating they resemble human Sonic hedgehog and group 3 and 4 medulloblastoma and CNS neuroblastoma with FOXR2 activation. This represents the first genetically induced mouse model of CNS-PNET and a rare model of group 3 and 4 medulloblastoma. We identified several putative proto-oncogenes including Arhgap36, Megf10, and Foxr2. Genetic manipulation of these genes demonstrated a robust impact on tumorigenesis in vitro and in vivo. We also determined that FOXR2 interacts with N-MYC, increases C-MYC protein stability, and activates FAK/SRC signaling. Altogether, our study identified several promising therapeutic targets in medulloblastoma and CNS-PNET. Significance: A transposon-induced mouse model identifies several novel genetic drivers and potential therapeutic targets in medulloblastoma and CNS-PNET." @default.
- W2912167963 created "2019-02-21" @default.
- W2912167963 creator A5002801148 @default.
- W2912167963 creator A5005626540 @default.
- W2912167963 creator A5006061200 @default.
- W2912167963 creator A5006897627 @default.
- W2912167963 creator A5013686950 @default.
- W2912167963 creator A5019028542 @default.
- W2912167963 creator A5019961826 @default.
- W2912167963 creator A5020001489 @default.
- W2912167963 creator A5022057184 @default.
- W2912167963 creator A5022310517 @default.
- W2912167963 creator A5022981209 @default.
- W2912167963 creator A5027575883 @default.
- W2912167963 creator A5030117758 @default.
- W2912167963 creator A5033857154 @default.
- W2912167963 creator A5034907718 @default.
- W2912167963 creator A5040756158 @default.
- W2912167963 creator A5042241049 @default.
- W2912167963 creator A5042915776 @default.
- W2912167963 creator A5043724824 @default.
- W2912167963 creator A5052243927 @default.
- W2912167963 creator A5053563254 @default.
- W2912167963 creator A5055594826 @default.
- W2912167963 creator A5056439897 @default.
- W2912167963 creator A5060720802 @default.
- W2912167963 creator A5066651467 @default.
- W2912167963 creator A5069503826 @default.
- W2912167963 creator A5071660469 @default.
- W2912167963 creator A5077080844 @default.
- W2912167963 creator A5081758565 @default.
- W2912167963 creator A5083880051 @default.
- W2912167963 creator A5084774714 @default.
- W2912167963 creator A5089238214 @default.
- W2912167963 creator A5090277365 @default.
- W2912167963 date "2019-03-01" @default.
- W2912167963 modified "2023-10-14" @default.
- W2912167963 title "<i>Sleeping Beauty</i> Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors" @default.
- W2912167963 cites W1500013333 @default.
- W2912167963 cites W1761323037 @default.
- W2912167963 cites W1893588436 @default.
- W2912167963 cites W1974798136 @default.
- W2912167963 cites W1979190481 @default.
- W2912167963 cites W1987107175 @default.
- W2912167963 cites W1987704199 @default.
- W2912167963 cites W2009874228 @default.
- W2912167963 cites W2011334551 @default.
- W2912167963 cites W2018846118 @default.
- W2912167963 cites W2019231810 @default.
- W2912167963 cites W2038120157 @default.
- W2912167963 cites W2040707239 @default.
- W2912167963 cites W2041366584 @default.
- W2912167963 cites W2044423100 @default.
- W2912167963 cites W2055167407 @default.
- W2912167963 cites W2074317576 @default.
- W2912167963 cites W2079852484 @default.
- W2912167963 cites W2082080058 @default.
- W2912167963 cites W2082279608 @default.
- W2912167963 cites W2102024140 @default.
- W2912167963 cites W2107135074 @default.
- W2912167963 cites W2125510350 @default.
- W2912167963 cites W2130550193 @default.
- W2912167963 cites W2133810023 @default.
- W2912167963 cites W2142932563 @default.
- W2912167963 cites W2148977460 @default.
- W2912167963 cites W2153398041 @default.
- W2912167963 cites W2160382843 @default.
- W2912167963 cites W2166326729 @default.
- W2912167963 cites W2169365861 @default.
- W2912167963 cites W2194938633 @default.
- W2912167963 cites W2271930111 @default.
- W2912167963 cites W2286322195 @default.
- W2912167963 cites W2468701645 @default.
- W2912167963 cites W2473061292 @default.
- W2912167963 cites W2527755488 @default.
- W2912167963 cites W2536549051 @default.
- W2912167963 cites W2566074745 @default.
- W2912167963 cites W2568193334 @default.
- W2912167963 cites W2580617915 @default.
- W2912167963 cites W2610004309 @default.
- W2912167963 cites W2619990998 @default.
- W2912167963 cites W2737542366 @default.
- W2912167963 cites W2766948837 @default.
- W2912167963 cites W2783363449 @default.
- W2912167963 cites W2784253551 @default.
- W2912167963 cites W4250359879 @default.
- W2912167963 cites W574402394 @default.
- W2912167963 cites W616296877 @default.
- W2912167963 doi "https://doi.org/10.1158/0008-5472.can-18-1261" @default.
- W2912167963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6397665" @default.
- W2912167963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30674530" @default.
- W2912167963 hasPublicationYear "2019" @default.
- W2912167963 type Work @default.
- W2912167963 sameAs 2912167963 @default.
- W2912167963 citedByCount "29" @default.
- W2912167963 countsByYear W29121679632019 @default.
- W2912167963 countsByYear W29121679632020 @default.
- W2912167963 countsByYear W29121679632021 @default.