Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912169226> ?p ?o ?g. }
- W2912169226 endingPage "15897" @default.
- W2912169226 startingPage "15885" @default.
- W2912169226 abstract "Abstract Glutathione transferases (GSTs) play an important role in retinal pathophysiology. Within this family, the GSTP isoform is known as an endogenous regulator of cell survival and proliferation pathways and of cellular responses to oxidative stress. In the present study we silenced GSTP in R28 cells, a retinal precursor cell line with markers of both glial and neuronal origin, and obtained stable clones which were viable and, unexpectedly, characterized by a more neuronal phenotype. The degree of neuronal differentiation was inversely correlated with GSTP residual expression levels. The clone with the lowest expression of GSTP showed metabolic reprogramming, a more favorable redox status and, despite its neuronal phenotype, a sensitivity to glutamate and 4‐hydroxynonenal toxicity comparable to that of control cells. Altogether, our evidence shows that near full depletion of GSTP in retinal precursor cells, triggers neuronal differentiation and prosurvival metabolic changes." @default.
- W2912169226 created "2019-02-21" @default.
- W2912169226 creator A5009225717 @default.
- W2912169226 creator A5012276258 @default.
- W2912169226 creator A5022647583 @default.
- W2912169226 creator A5023688751 @default.
- W2912169226 creator A5034948446 @default.
- W2912169226 creator A5035520847 @default.
- W2912169226 creator A5054158026 @default.
- W2912169226 creator A5057953941 @default.
- W2912169226 creator A5058862530 @default.
- W2912169226 creator A5077293812 @default.
- W2912169226 creator A5078106449 @default.
- W2912169226 creator A5089589406 @default.
- W2912169226 creator A5091541180 @default.
- W2912169226 date "2019-02-11" @default.
- W2912169226 modified "2023-09-26" @default.
- W2912169226 title "Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells" @default.
- W2912169226 cites W1581414347 @default.
- W2912169226 cites W1986824675 @default.
- W2912169226 cites W1991759635 @default.
- W2912169226 cites W1993069312 @default.
- W2912169226 cites W2010414428 @default.
- W2912169226 cites W2021477435 @default.
- W2912169226 cites W2028150557 @default.
- W2912169226 cites W2032531051 @default.
- W2912169226 cites W2035743526 @default.
- W2912169226 cites W2054179928 @default.
- W2912169226 cites W2059700063 @default.
- W2912169226 cites W2077450385 @default.
- W2912169226 cites W2087815516 @default.
- W2912169226 cites W2088113277 @default.
- W2912169226 cites W2096220994 @default.
- W2912169226 cites W2136953396 @default.
- W2912169226 cites W2150081412 @default.
- W2912169226 cites W2160775511 @default.
- W2912169226 cites W2161594343 @default.
- W2912169226 cites W2166029855 @default.
- W2912169226 cites W2227575128 @default.
- W2912169226 cites W2412031353 @default.
- W2912169226 cites W2529411682 @default.
- W2912169226 cites W2578048051 @default.
- W2912169226 cites W2594390960 @default.
- W2912169226 cites W2784734859 @default.
- W2912169226 cites W4238581030 @default.
- W2912169226 doi "https://doi.org/10.1002/jcp.28246" @default.
- W2912169226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30741416" @default.
- W2912169226 hasPublicationYear "2019" @default.
- W2912169226 type Work @default.
- W2912169226 sameAs 2912169226 @default.
- W2912169226 citedByCount "1" @default.
- W2912169226 countsByYear W29121692262023 @default.
- W2912169226 crossrefType "journal-article" @default.
- W2912169226 hasAuthorship W2912169226A5009225717 @default.
- W2912169226 hasAuthorship W2912169226A5012276258 @default.
- W2912169226 hasAuthorship W2912169226A5022647583 @default.
- W2912169226 hasAuthorship W2912169226A5023688751 @default.
- W2912169226 hasAuthorship W2912169226A5034948446 @default.
- W2912169226 hasAuthorship W2912169226A5035520847 @default.
- W2912169226 hasAuthorship W2912169226A5054158026 @default.
- W2912169226 hasAuthorship W2912169226A5057953941 @default.
- W2912169226 hasAuthorship W2912169226A5058862530 @default.
- W2912169226 hasAuthorship W2912169226A5077293812 @default.
- W2912169226 hasAuthorship W2912169226A5078106449 @default.
- W2912169226 hasAuthorship W2912169226A5089589406 @default.
- W2912169226 hasAuthorship W2912169226A5091541180 @default.
- W2912169226 hasConcept C104317684 @default.
- W2912169226 hasConcept C119056186 @default.
- W2912169226 hasConcept C127716648 @default.
- W2912169226 hasConcept C148738053 @default.
- W2912169226 hasConcept C1491633281 @default.
- W2912169226 hasConcept C153911025 @default.
- W2912169226 hasConcept C181199279 @default.
- W2912169226 hasConcept C2776151105 @default.
- W2912169226 hasConcept C2776907368 @default.
- W2912169226 hasConcept C2780827179 @default.
- W2912169226 hasConcept C538909803 @default.
- W2912169226 hasConcept C54355233 @default.
- W2912169226 hasConcept C55493867 @default.
- W2912169226 hasConcept C77255625 @default.
- W2912169226 hasConcept C81089528 @default.
- W2912169226 hasConcept C81885089 @default.
- W2912169226 hasConcept C86803240 @default.
- W2912169226 hasConcept C95444343 @default.
- W2912169226 hasConceptScore W2912169226C104317684 @default.
- W2912169226 hasConceptScore W2912169226C119056186 @default.
- W2912169226 hasConceptScore W2912169226C127716648 @default.
- W2912169226 hasConceptScore W2912169226C148738053 @default.
- W2912169226 hasConceptScore W2912169226C1491633281 @default.
- W2912169226 hasConceptScore W2912169226C153911025 @default.
- W2912169226 hasConceptScore W2912169226C181199279 @default.
- W2912169226 hasConceptScore W2912169226C2776151105 @default.
- W2912169226 hasConceptScore W2912169226C2776907368 @default.
- W2912169226 hasConceptScore W2912169226C2780827179 @default.
- W2912169226 hasConceptScore W2912169226C538909803 @default.
- W2912169226 hasConceptScore W2912169226C54355233 @default.
- W2912169226 hasConceptScore W2912169226C55493867 @default.
- W2912169226 hasConceptScore W2912169226C77255625 @default.