FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912171001> ?p ?o ?g. }

• W2912171001 endingPage "388" @default.
• W2912171001 startingPage "377" @default.
• W2912171001 abstract "The main objective of this study was to analyze validated cases of drug-induced anaphylactic reactions in children with regard to incriminated drugs, clinical characteristics, and associated factors. A further objective was to compare differences in incriminated drugs and characteristics between validated cases and a reference excluding anaphylactic reaction cases (basic dataset).Spontaneous reports of anaphylactic reactions in children (0-17 years) registered between January 2000 to December 2016 were extracted from the adverse drug reaction database of the German Federal Institute for Drugs and Medical Devices. These reports were restricted to drugs for which at least four cases were found. After case validation, 159 reports remained (validated dataset) and were compared with the basic dataset (n = 12.168 reports) using inferential statistics.Estimated yearly increase of reports (36.8 vs 0.1), most frequently incriminated drugs (antibiotics 30.2% vs 11%, analgesics/antipyretics 22.0% vs 5.6%; P values less than 0.001) and route of administration (38.4% vs 6.7%) differed between the validated dataset and the basic dataset. Validated cases differed in severity (higher with atracurium), reported symptoms (urticaria leading with analgesics), and associated factors (atopy/allergy rarely reported with antibiotics) depending on the incriminated drug class. In 13.8% (11.3% if excluding repeated readministration in one person) of the cases, the drug had not been tolerated before.A heterogeneous clinical phenotype with differences in associated factors was observed, suggesting different underlying mechanisms triggered by the different drug groups. Occurrence of serious drug-induced anaphylactic reactions in children could be reduced by carefully considering patient history." @default.
• W2912171001 created "2019-02-21" @default.
• W2912171001 creator A5031620559 @default.
• W2912171001 creator A5053823894 @default.
• W2912171001 creator A5066784352 @default.
• W2912171001 creator A5077315579 @default.
• W2912171001 creator A5079549118 @default.
• W2912171001 date "2019-01-31" @default.
• W2912171001 modified "2023-10-17" @default.
• W2912171001 title "Drug-induced anaphylactic reactions in children: A retrospective analysis of 159 validated spontaneous reports" @default.
• W2912171001 cites W1453424051 @default.
• W2912171001 cites W1556769515 @default.
• W2912171001 cites W1681728269 @default.
• W2912171001 cites W1765914614 @default.
• W2912171001 cites W1834460521 @default.
• W2912171001 cites W1963612969 @default.
• W2912171001 cites W1964511881 @default.
• W2912171001 cites W1967259894 @default.
• W2912171001 cites W1975511229 @default.
• W2912171001 cites W1977112754 @default.
• W2912171001 cites W1984190270 @default.
• W2912171001 cites W1998542572 @default.
• W2912171001 cites W2001847168 @default.
• W2912171001 cites W2009890917 @default.
• W2912171001 cites W2026501754 @default.
• W2912171001 cites W2037489995 @default.
• W2912171001 cites W2044944166 @default.
• W2912171001 cites W2048316653 @default.
• W2912171001 cites W2055387073 @default.
• W2912171001 cites W2056811697 @default.
• W2912171001 cites W2060324994 @default.
• W2912171001 cites W2070045958 @default.
• W2912171001 cites W2079936227 @default.
• W2912171001 cites W2082276693 @default.
• W2912171001 cites W2085752173 @default.
• W2912171001 cites W2091472331 @default.
• W2912171001 cites W2097901958 @default.
• W2912171001 cites W2109311654 @default.
• W2912171001 cites W2117983722 @default.
• W2912171001 cites W2129271442 @default.
• W2912171001 cites W2129917430 @default.
• W2912171001 cites W2132885099 @default.
• W2912171001 cites W2150314456 @default.
• W2912171001 cites W2153972688 @default.
• W2912171001 cites W2171123482 @default.
• W2912171001 cites W2183409830 @default.
• W2912171001 cites W2187520498 @default.
• W2912171001 cites W2400802781 @default.
• W2912171001 cites W2527251445 @default.
• W2912171001 cites W2618311856 @default.
• W2912171001 cites W2620465248 @default.
• W2912171001 cites W2749899280 @default.
• W2912171001 cites W2770277754 @default.
• W2912171001 cites W2912171001 @default.
• W2912171001 cites W4241199319 @default.
• W2912171001 cites W4289815981 @default.
• W2912171001 doi "https://doi.org/10.1002/pds.4726" @default.
• W2912171001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6590409" @default.
• W2912171001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30706619" @default.
• W2912171001 hasPublicationYear "2019" @default.
• W2912171001 type Work @default.
• W2912171001 sameAs 2912171001 @default.
• W2912171001 citedByCount "10" @default.
• W2912171001 countsByYear W29121710012019 @default.
• W2912171001 countsByYear W29121710012020 @default.
• W2912171001 countsByYear W29121710012021 @default.
• W2912171001 countsByYear W29121710012022 @default.
• W2912171001 crossrefType "journal-article" @default.
• W2912171001 hasAuthorship W2912171001A5031620559 @default.
• W2912171001 hasAuthorship W2912171001A5053823894 @default.
• W2912171001 hasAuthorship W2912171001A5066784352 @default.
• W2912171001 hasAuthorship W2912171001A5077315579 @default.
• W2912171001 hasAuthorship W2912171001A5079549118 @default.
• W2912171001 hasBestOaLocation W29121710011 @default.
• W2912171001 hasConcept C126322002 @default.
• W2912171001 hasConcept C167135981 @default.
• W2912171001 hasConcept C203014093 @default.
• W2912171001 hasConcept C207480886 @default.
• W2912171001 hasConcept C2775933838 @default.
• W2912171001 hasConcept C2777697326 @default.
• W2912171001 hasConcept C2778176773 @default.
• W2912171001 hasConcept C2779060952 @default.
• W2912171001 hasConcept C2779252780 @default.
• W2912171001 hasConcept C2780035454 @default.
• W2912171001 hasConcept C2780542314 @default.
• W2912171001 hasConcept C2780820201 @default.
• W2912171001 hasConcept C2909843257 @default.
• W2912171001 hasConcept C2993432071 @default.
• W2912171001 hasConcept C501593827 @default.
• W2912171001 hasConcept C57658597 @default.
• W2912171001 hasConcept C71924100 @default.
• W2912171001 hasConcept C86803240 @default.
• W2912171001 hasConcept C89423630 @default.
• W2912171001 hasConcept C98274493 @default.
• W2912171001 hasConceptScore W2912171001C126322002 @default.
• W2912171001 hasConceptScore W2912171001C167135981 @default.
• W2912171001 hasConceptScore W2912171001C203014093 @default.
• W2912171001 hasConceptScore W2912171001C207480886 @default.

• next