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- W2912171715 abstract "The blood–thymus barrier is a functional and selective barrier separating T-lymphocytes from blood and cortical capillaries in the cortex of the thymus. The existence of this barrier was proposed for the first in time in 1961 by Marshall and White and demonstrated in 1963 by Clark and Weiss. The most clear morphological evidence concerning the existence of the blood–thymus barrier may be attributed to the collaborative work published in 1972 by two scientists, Morris Karnovsky and Elio Raviola. Raviola and Karnovsky, using horseradish peroxidase as a permeability tracer, demonstrated that the venules at the corticomedullary junction are the site of leakage for blood antigens, whereas the capillaries draining the cortex are largely impermeable. Other permeability studies have confirmed the existence of a blood–thymus barrier, which allow the access to low molecular weight tracers, whereas most exclude high molecular weight particles." @default.
- W2912171715 created "2019-02-21" @default.
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- W2912171715 date "2017-01-01" @default.
- W2912171715 modified "2023-09-28" @default.
- W2912171715 title "The Discovery of the Blood–Thymus Barrier" @default.
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- W2912171715 doi "https://doi.org/10.1016/b978-0-12-811313-4.00003-6" @default.
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